Dehydrosqualene synthase

Details

Name
Dehydrosqualene synthase
Synonyms
  • 2.5.1.96
  • 4,4'-diapophytoene synthase
  • DAP synthase
  • Diapophytoene synthase
Gene Name
crtM
Organism
Staphylococcus aureus
Amino acid sequence
>lcl|BSEQ0017250|Dehydrosqualene synthase
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFL
NQIKEDIQSIEKYPYEYHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMF
ETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFENE
RIYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFRDVMDQIKVFSIEAQPI
IELAARIYIEILDEVRQANYTLHERVFVEKRKKAKLFHEINSKYHRI
Number of residues
287
Molecular Weight
34312.78
Theoretical pI
6.05
GO Classification
Functions
transferase activity, transferring alkyl or aryl (other than methyl) groups
Processes
carotenoid biosynthetic process
General Function
Transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific Function
Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid dehydrosqualene (4,4'-diapophytoene). This is the initial step in the biosynthesis of staphyloxanthin, an orange carotenoid present in most staphylococci strains.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDA9JQL9
UniProtKB Entry NameCRTM_STAAU
GenBank Protein ID161788394
GenBank Gene IDAM920687
General References
  1. Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E: A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 7;319(5868):1391-4. doi: 10.1126/science.1153018. Epub 2008 Feb 14. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07420(1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acidexperimentalunknownDetails
DB07424Tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonateexperimentalunknownDetails
DB04695Farnesyl thiopyrophosphateexperimentalunknownDetails