1,4-dihydroxy-2-naphthoyl-CoA synthase
Details
- Name
- 1,4-dihydroxy-2-naphthoyl-CoA synthase
- Synonyms
- 4.1.3.36
- DHNA-CoA synthase
- Gene Name
- menB
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051185|1,4-dihydroxy-2-naphthoyl-CoA synthase MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNA FRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASG DTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYAR FKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELE TVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFL QKRPPDWSPFPRYF
- Number of residues
- 314
- Molecular Weight
- 34688.715
- Theoretical pI
- Not Available
- GO Classification
- Functions1,4-dihydroxy-2-naphthoyl-CoA synthase activityProcessesmenaquinone biosynthetic process / protein hexamerizationComponentsplasma membrane
- General Function
- Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
- Specific Function
- 1,4-dihydroxy-2-naphthoyl-coa synthase activity
- Pfam Domain Function
- ECH_1 (PF00378)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051186|1,4-dihydroxy-2-naphthoyl-CoA synthase (menB) GTGGTGGCTCCAGCCGGCGAACAAGGACGGAGTTCAACAGCCTTGAGTGACAACCCTTTT GATGCCAAGGCGTGGCGGCTCGTGGACGGGTTCGACGATCTGACCGACATCACCTACCAC CGCCACGTCGACGATGCCACGGTGCGGGTGGCGTTCAACCGCCCTGAAGTGCGCAACGCA TTTCGCCCGCACACCGTCGACGAGCTGTACCGGGTGCTCGACCATGCACGAATGTCGCCC GACGTCGGAGTGGTGCTGCTGACCGGCAACGGGCCGTCCCCGAAGGACGGCGGCTGGGCG TTCTGCTCCGGCGGCGACCAACGAATTCGTGGGCGCAGCGGTTACCAGTACGCCAGCGGA GACACCGCGGACACGGTTGATGTCGCCCGCGCCGGCCGGTTGCACATCCTGGAGGTGCAG CGGCTGATCCGGTTCATGCCCAAGGTGGTCATTTGTCTGGTCAATGGCTGGGCGGCCGGC GGGGGACACAGCCTGCACGTGGTCTGCGATCTCACCCTGGCCAGCCGCGAGTACGCCCGC TTCAAGCAGACCGACGCCGACGTCGGCAGCTTCGATGGCGGTTACGGCAGCGCATATCTG GCCCGTCAGGTCGGCCAGAAGTTTGCCCGCGAGATCTTCTTCCTAGGCCGCACCTACACC GCCGAGCAGATGCACCAGATGGGCGCGGTCAACGCGGTGGCCGAACACGCCGAGCTGGAG ACAGTGGGGCTGCAGTGGGCGGCCGAGATCAACGCGAAATCGCCTCAGGCGCAACGGATG CTGAAGTTCGCGTTCAACCTGCTCGACGACGGGCTGGTGGGTCAGCAACTGTTTGCCGGT GAGGCCACCCGCCTGGCCTACATGACCGACGAGGCCGTCGAAGGCCGCGACGCCTTCCTA CAGAAGCGTCCCCCCGACTGGAGCCCGTTTCCGCGCTATTTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WNP5 UniProtKB Entry Name MENB_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Jiang M, Chen M, Guo ZF, Guo Z: A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli. J Biol Chem. 2010 Sep 24;285(39):30159-69. doi: 10.1074/jbc.M110.147702. Epub 2010 Jul 19. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Truglio JJ, Theis K, Feng Y, Gajda R, Machutta C, Tonge PJ, Kisker C: Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis. J Biol Chem. 2003 Oct 24;278(43):42352-60. Epub 2003 Aug 8. [Article]
- Johnston JM, Arcus VL, Baker EN: Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1199-206. Epub 2005 Aug 16. [Article]
- Li HJ, Li X, Liu N, Zhang H, Truglio JJ, Mishra S, Kisker C, Garcia-Diaz M, Tonge PJ: Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. Biochemistry. 2011 Nov 8;50(44):9532-44. doi: 10.1021/bi200877x. Epub 2011 Oct 11. [Article]