Formyl-CoA:oxalate CoA-transferase
Details
- Name
- Formyl-CoA:oxalate CoA-transferase
- Synonyms
- 2.8.3.16
- FCOCT
- Formyl-coenzyme A transferase
- Gene Name
- frc
- Organism
- Oxalobacter formigenes
- Amino acid sequence
>lcl|BSEQ0010916|Formyl-CoA:oxalate CoA-transferase MTKPLDGINVLDFTHVQAGPACTQMMGFLGANVIKIERRGSGDMTRGWLQDKPNVDSLYF TMFNCNKRSIELDMKTPEGKELLEQMIKKADVMVENFGPGALDRMGFTWEYIQELNPRVI LASVKGYAEGHANEHLKVYENVAQCSGGAAATTGFWDGPPTVSGAALGDSNSGMHLMIGI LAALEMRHKTGRGQKVAVAMQDAVLNLVRIKLRDQQRLERTGILAEYPQAQPNFAFDRDG NPLSFDNITSVPRGGNAGGGGQPGWMLKCKGWETDADSYVYFTIAANMWPQICDMIDKPE WKDDPAYNTFEGRVDKLMDIFSFIETKFADKDKFEVTEWAAQYGIPCGPVMSMKELAHDP SLQKVGTVVEVVDEIRGNHLTVGAPFKFSGFQPEITRAPLLGEHTDEVLKELGLDDAKIK ELHAKQVV
- Number of residues
- 428
- Molecular Weight
- 47326.775
- Theoretical pI
- 5.1
- GO Classification
- Functionsformyl-CoA transferase activityProcessesoxalate catabolic processComponentscytoplasm
- General Function
- Formyl-coa transferase activity
- Specific Function
- Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy. Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. It can also use succinate as acceptor.
- Pfam Domain Function
- CoA_transf_3 (PF02515)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0002602|1287 bp ATGACTAAACCATTAGATGGAATTAATGTGCTTGACTTTACCCACGTCCAGGCAGGTCCT GCCTGTACACAGATGATGGGTTTCTTGGGCGCAAACGTCATCAAGATTGAAAGACGTGGT TCCGGAGATATGACTCGTGGATGGCTGCAGGACAAACCAAATGTTGATTCCCTGTATTTC ACGATGTTCAACTGTAACAAACGTTCGATTGAACTGGACATGAAAACCCCGGAAGGCAAA GAGCTTCTGGAACAGATGATCAAGAAAGCCGACGTCATGGTCGAAAACTTCGGACCAGGC GCACTGGACCGTATGGGCTTTACTTGGGAATACATTCAGGAACTGAATCCACGCGTCATT CTGGCTTCCGTTAAAGGCTATGCAGAAGGCCACGCCAACGAACACCTGAAAGTTTATGAA AACGTTGCACAGTGTTCCGGCGGTGCTGCAGCTACCACCGGTTTCTGGGATGGTCCTCCA ACCGTTTCCGGCGCTGCTCTGGGTGACTCCAACTCCGGTATGCACCTGATGATCGGTATT CTGGCCGCTCTGGAAATGCGTCACAAAACCGGCCGTGGTCAGAAAGTTGCCGTCGCTATG CAGGACGCTGTTCTGAATCTGGTTCGTATCAAACTGCGTGACCAGCAACGTCTGGAAAGA ACCGGCATTCTGGCTGAATACCCACAGGCTCAGCCTAACTTTGCCTTCGACAGAGACGGT AACCCACTGTCCTTCGACAACATCACTTCCGTTCCACGTGGTGGTAACGCAGGTGGCGGC GGCCAGCCAGGCTGGATGCTGAAATGTAAAGGTTGGGAAACCGATGCGGACTCCTACGTT TACTTCACCATCGCTGCAAACATGTGGCCACAGATCTGCGACATGATCGACAAGCCAGAA TGGAAAGACGACCCAGCCTACAACACATTCGAAGGTCGTGTTGACAAGCTGATGGACATC TTCTCCTTCATCGAAACCAAGTTCGCTGACAAGGACAAATTCGAAGTTACCGAATGGGCT GCCCAGTACGGCATTCCTTGCGGTCCGGTCATGTCCATGAAAGAACTGGCTCACGATCCT TCCCTGCAGAAAGTTGGTACCGTCGTTGAAGTTGTCGACGAAATTCGTGGTAACCACCTG ACCGTTGGCGCACCGTTCAAATTCTCCGGATTCCAGCCGGAAATTACCCGTGCTCCGCTG TTGGGCGAACATACCGACGAAGTTCTGAAAGAACTGGGTCTTGACGATGCCAAGATCAAG GAACTGCATGCAAAACAGGTAGTTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O06644 UniProtKB Entry Name FCTA_OXAFO GenBank Protein ID 2102704 GenBank Gene ID U82167 - General References
- Sidhu H, Ogden SD, Lung HY, Luttge BG, Baetz AL, Peck AB: DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes. J Bacteriol. 1997 May;179(10):3378-81. [Article]
- Baetz AL, Allison MJ: Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes. J Bacteriol. 1990 Jul;172(7):3537-40. [Article]
- Ricagno S, Jonsson S, Richards N, Lindqvist Y: Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. EMBO J. 2003 Jul 1;22(13):3210-9. [Article]
- Jonsson S, Ricagno S, Lindqvist Y, Richards NG: Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes. J Biol Chem. 2004 Aug 20;279(34):36003-12. Epub 2004 Jun 21. [Article]
- Toyota CG, Berthold CL, Gruez A, Jonsson S, Lindqvist Y, Cambillau C, Richards NG: Differential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferase. J Bacteriol. 2008 Apr;190(7):2556-64. doi: 10.1128/JB.01823-07. Epub 2008 Feb 1. [Article]
- Berthold CL, Toyota CG, Richards NG, Lindqvist Y: Reinvestigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase. J Biol Chem. 2008 Mar 7;283(10):6519-29. Epub 2007 Dec 27. [Article]