Histone deacetylase 3
Details
- Name
- Histone deacetylase 3
- Synonyms
- 3.5.1.98
- HD3
- RPD3-2
- SMAP45
- Gene Name
- HDAC3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004649|Histone deacetylase 3 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN DKESDVEI
- Number of residues
- 428
- Molecular Weight
- 48847.385
- Theoretical pI
- 4.79
- GO Classification
- Functionschromatin binding / chromatin DNA binding / cyclin binding / enzyme binding / histone deacetylase activity / histone deacetylase binding / NAD-dependent histone deacetylase activity (H3-K14 specific) / NF-kappaB binding / protein deacetylase activity / transcription corepressor activity / transcription factor bindingProcessescellular lipid metabolic process / cellular response to fluid shear stress / chromatin modification / chromatin organization / circadian regulation of gene expression / circadian rhythm / negative regulation of apoptotic process / negative regulation of cardiac muscle cell differentiation / negative regulation of cell cycle / negative regulation of JNK cascade / negative regulation of nucleic acid-templated transcription / negative regulation of sequence-specific DNA binding transcription factor activity / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / neurotrophin TRK receptor signaling pathway / Notch signaling pathway / positive regulation of protein phosphorylation / positive regulation of TOR signaling / positive regulation of transcription factor import into nucleus / positive regulation of transcription from RNA polymerase II promoter / protein deacetylation / regulation of mitotic cell cycle / regulation of multicellular organism growth / regulation of protein stability / small molecule metabolic process / spindle assembly / transcription, DNA-templatedComponentscytoplasm / cytosol / Golgi apparatus / histone deacetylase complex / nucleoplasm / nucleus / plasma membrane / spindle microtubule / transcriptional repressor complex
- General Function
- Transcription factor binding
- Specific Function
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
- Pfam Domain Function
- Hist_deacetyl (PF00850)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0021323|Histone deacetylase 3 (HDAC3) ATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCT GGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGT CTCTATAAGAAGATGATCGTCTTCAAGCCATACCAGGCCTCCCAACATGACATGTGCCGC TTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGC TTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTC TTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAAC AAGATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAG GCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTAC CACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCT TTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTC CCTGGCACAGGTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAAC GTGCCCCTGCGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTTATC AACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAGTGTGGAGCTGACTCT CTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGGGGAATGCGTT GAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTC CGAAATGTTGCCCGCTGCTGGACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGT GAGGAGCTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCA GATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAG ACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTG CCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCT GAGGAGAACTATAGCAGGCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAAT GACAAGGAAAGCGATGTGGAGATTTAA
- Chromosome Location
- 5
- Locus
- 5q31
- External Identifiers
Resource Link UniProtKB ID O15379 UniProtKB Entry Name HDAC3_HUMAN GenBank Protein ID 2326173 GenBank Gene ID U66914 GenAtlas ID HDAC3 HGNC ID HGNC:4854 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02546 Vorinostat approved, investigational yes inhibitor Details DB05223 Pracinostat investigational unknown Details DB11830 Mocetinostat investigational unknown Details DB05015 Belinostat approved, investigational yes inhibitor Details DB06603 Panobinostat approved, investigational yes inhibitor Details DB02546 Vorinostat approved, investigational unknown inhibitor Details DB12847 Pyroxamide investigational unknown inhibitor Details DB00313 Valproic acid approved, investigational unknown inhibitor Details DB11841 Entinostat investigational yes inhibitor Details DB06819 Phenylbutyric acid approved, investigational unknown inhibitor Details DB12645 Givinostat investigational unknown inhibitor Details DB06176 Romidepsin approved, investigational unknown inhibitor Details DB01262 Decitabine approved, investigational unknown inhibitor Details DB12565 Abexinostat investigational unknown inhibitor Details DB03766 Propanoic acid approved, vet_approved unknown inhibitor Details