Monocarboxylate transporter 7
Details
- Name
- Monocarboxylate transporter 7
- Synonyms
- MCT 6
- MCT 7
- MCT6
- MCT7
- Monocarboxylate transporter 6
- Solute carrier family 16 member 6
- Gene Name
- SLC16A6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0036965|Monocarboxylate transporter 7 MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVA IGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWR YSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDS GVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALF GLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY IELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSS AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQ HHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV
- Number of residues
- 523
- Molecular Weight
- 57392.83
- Theoretical pI
- 8.64
- GO Classification
- Functionsmonocarboxylic acid transmembrane transporter activity / symporter activityProcessesion transmembrane transport / monocarboxylic acid transportComponentsintegral component of plasma membrane / membrane
- General Function
- Symporter activity
- Specific Function
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 22-42 63-83 92-112 119-139 150-170 185-205 300-320 331-351 359-379 382-402 424-444 453-473
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0009984|Monocarboxylate transporter 7 (SLC16A6) ATGACCCAAAATAAATTAAAGCTTTGTTCCAAAGCCAATGTGTATACTGAAGTGCCTGAT GGAGGATGGGGCTGGGCGGTAGCTGTTTCATTTTTCTTCGTTGAAGTCTTCACCTACGGC ATCATCAAGACATTTGGTGTCTTCTTTAATGACTTAATGGACAGTTTTAATGAATCCAAT AGCAGGATCTCATGGATAATCTCAATCTGTGTGTTTGTCTTAACATTTTCAGCTCCCCTC GCCACAGTCCTGAGCAATCGTTTCGGACACCGTCTGGTAGTGATGTTGGGGGGGCTACTT GTCAGCACCGGGATGGTGGCCGCCTCCTTCTCACAAGAGGTTTCTCATATGTACGTCGCC ATCGGCATCATCTCTGGTCTGGGATACTGCTTTAGTTTTCTCCCAACTGTAACCATCCTA TCACAATATTTTGGCAAAAGACGTTCCATAGTCACTGCAGTTGCTTCCACAGGAGAATGT TTCGCTGTGTTTGCTTTCGCACCAGCAATCATGGCTCTGAAGGAGCGCATTGGCTGGAGA TACAGCCTCCTCTTCGTGGGCCTACTACAGTTAAACATTGTCATCTTCGGAGCACTGCTC AGACCCATCTTTATCAGAGGACCAGCGTCACCGAAAATAGTCATCCAGGAAAATCGGAAA GAAGCGCAGTATATGCTTGAAAATGAGAAAACACGAACCTCAATAGACTCCATTGACTCA GGAGTAGAACTAACTACCTCACCTAAAAATGTGCCTACTCACACTAACCTGGAACTGGAG CCGAAGGCCGACATGCAGCAGGTCCTGGTGAAGACCAGCCCCAGGCCAAGCGAAAAGAAA GCCCCGCTATTAGACTTCTCCATTTTGAAAGAGAAAAGTTTTATTTGTTATGCATTATTT GGTCTCTTTGCAACACTGGGATTCTTTGCACCTTCCTTGTACATCATTCCTCTGGGCATT AGTCTGGGCATTGACCAGGACCGCGCTGCTTTTTTATTATCTACGATGGCCATTGCAGAA GTTTTCGGAAGGATCGGAGCTGGTTTTGTCCTCAACAGGGAGCCCATTCGTAAGATTTAC ATTGAGCTCATCTGCGTCATCTTATTGACTGTGTCTCTGTTTGCCTTTACTTTTGCTACT GAATTCTGGGGTCTAATGTCATGCAGCATATTTTTTGGGTTTATGGTTGGAACAATAGGA GGGACTCACATTCCACTGCTTGCTGAGGATGATGTCGTGGGCATTGAGAAGATGTCTTCT GCAGCTGGGGTCTACATCTTCATTCAGAGCATAGCAGGACTGGCTGGACCGCCCCTTGCA GGTTTGTTGGTGGACCAAAGTAAGATCTACAGCAGGGCCTTCTACTCCTGCGCAGCTGGC ATGGCCCTGGCTGCTGTGTGCCTCGCCCTGGTGAGACCGTGTAAGATGGGACTGTGCCAG CATCATCACTCAGGTGAAACAAAGGTAGTGAGCCATCGTGGGAAGACTTTACAGGACATA CCTGAAGACTTTCTGGAAATGGATCTTGCAAAAAATGAGCACAGAGTTCACGTGCAAATG GAGCCGGTATGA
- Chromosome Location
- 17
- Locus
- 17q24.2
- External Identifiers
Resource Link UniProtKB ID O15403 UniProtKB Entry Name MOT7_HUMAN GenBank Protein ID 2463632 GenBank Gene ID U79745 GenAtlas ID SLC16A6 HGNC ID HGNC:10927 - General References
- Price NT, Jackson VN, Halestrap AP: Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J. 1998 Jan 15;329 ( Pt 2):321-8. [Article]
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- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
- Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]