Motilin receptor
Details
- Name
- Motilin receptor
- Synonyms
- G-protein coupled receptor 38
- GPR38
- MTLR
- MTLR1
- Gene Name
- MLNR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006793|Motilin receptor MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
- Number of residues
- 412
- Molecular Weight
- 45343.725
- Theoretical pI
- 10.17
- GO Classification
- FunctionsG-protein coupled receptor activity / growth hormone-releasing hormone receptor activityProcessesdigestion / G-protein coupled receptor signaling pathwayComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Growth hormone-releasing hormone receptor activity
- Specific Function
- Receptor for motilin.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 36-56 75-94 113-134 158-178 247-270 299-320 335-358
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012452|Motilin receptor (MLNR) ATGGGCAGCCCCTGGAACGGCAGCGACGGCCCCGAGGGGGCGCGGGAGCCGCCGTGGCCC GCGCTGCCGCCTTGCGACGAGCGCCGCTGCTCGCCCTTTCCCCTGGGGGCGCTGGTGCCG GTGACCGCTGTGTGCCTGTGCCTGTTCGTCGTCGGGGTGAGCGGCAACGTGGTGACCGTG ATGCTGATCGGGCGCTACCGGGACATGCGGACCACCACCAACTTGTACCTGGGCAGCATG GCCGTGTCCGACCTACTCATCCTGCTCGGGCTGCCGTTCGACCTGTACCGCCTCTGGCGC TCGCGGCCCTGGGTGTTCGGGCCGCTGCTCTGCCGCCTGTCCCTCTACGTGGGCGAGGGC TGCACCTACGCCACGCTGCTGCACATGACCGCGCTCAGCGTCGAGCGCTACCTGGCCATC TGCCGCCCGCTCCGCGCCCGCGTCTTGGTCACCCGGCGCCGCGTCCGCGCGCTCATCGCT GTGCTCTGGGCCGTGGCGCTGCTCTCTGCCGGTCCCTTCTTGTTCCTGGTGGGCGTCGAG CAGGACCCCGGCATCTCCGTAGTCCCGGGCCTCAATGGCACCGCGCGGATCGCCTCCTCG CCTCTCGCCTCGTCGCCGCCTCTCTGGCTCTCGCGGGCGCCACCGCCGTCCCCGCCGTCG GGGCCCGAGACCGCGGAGGCCGCGGCGCTGTTCAGCCGCGAATGCCGGCCGAGCCCCGCG CAGCTGGGCGCGCTGCGTGTCATGCTGTGGGTCACCACCGCCTACTTCTTCCTGCCCTTT CTGTGCCTCAGCATCCTCTACGGGCTCATCGGGCGGGAGCTGTGGAGCAGCCGGCGGCCG CTGCGAGGCCCGGCCGCCTCGGGGCGGGAGAGAGGCCACCGGCAGACCGTCCGCGTCCTG CTGGTGGTGGTTCTGGCATTTATAATTTGCTGGTTGCCCTTCCACGTTGGCAGAATCATT TACATAAACACGGAAGATTCGCGGATGATGTACTTCTCTCAGTACTTTAACATCGTCGCT CTGCAACTTTTCTATCTGAGCGCATCTATCAACCCAATCCTCTACAACCTCATTTCAAAG AAGTACAGAGCGGCGGCCTTTAAACTGCTGCTCGCAAGGAAGTCCAGGCCGAGAGGCTTC CACAGAAGCAGGGACACTGCGGGGGAAGTTGCAGGGGACACTGGAGGAGACACGGTGGGC TACACCGAGACAAGCGCTAACGTGAAGACGATGGGATAA
- Chromosome Location
- 13
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O43193 UniProtKB Entry Name MTLR_HUMAN GenBank Gene ID AL137000 GenAtlas ID MLNR HGNC ID HGNC:4495 - General References
- McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH: Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics. 1997 Dec 15;46(3):426-34. [Article]
- Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, O'Neill G, Van Der Ploeg LH, Evans J, Patchett AA, Smith RG, Howard AD: Receptor for motilin identified in the human gastrointestinal system. Science. 1999 Jun 25;284(5423):2184-8. [Article]
- Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [Article]
- Smith RG, Leonard R, Bailey AR, Palyha O, Feighner S, Tan C, Mckee KK, Pong SS, Griffin P, Howard A: Growth hormone secretagogue receptor family members and ligands. Endocrine. 2001 Feb;14(1):9-14. [Article]