Mitogen-activated protein kinase kinase kinase 13

Details

Name
Mitogen-activated protein kinase kinase kinase 13
Synonyms
  • 2.7.11.25
  • Leucine zipper-bearing kinase
  • LZK
  • Mixed lineage kinase
  • MLK
Gene Name
MAP3K13
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051808|Mitogen-activated protein kinase kinase kinase 13
MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
YSSATW
Number of residues
966
Molecular Weight
108295.145
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / identical protein binding / MAP kinase kinase kinase activity / metal ion binding / protein homodimerization activity / protein kinase binding / protein serine/threonine kinase activity
Processes
activation of MAPKK activity / JNK cascade / positive regulation of NF-kappaB transcription factor activity / protein autophosphorylation / protein phosphorylation
Components
cytoplasm / membrane
General Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051809|Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)
ATGGCCAACTTTCAGGAGCACCTGAGCTGCTCCTCTTCTCCACACTTACCCTTCAGTGAA
AGCAAAACCTTCAATGGACTACAAGATGAGCTCACAGCTATGGGGAACCACCCTTCTCCC
AAGCTGCTCGAGGACCAGCAGGAAAAGGGGATGGTACGAACAGAGCTAATCGAGAGCGTG
CACAGCCCCGTCACCACAACAGTGTTGACGAGCGTAAGTGAGGATTCCAGGGACCAGTTT
GAGAACAGCGTTCTTCAGCTAAGGGAACACGATGAATCAGAGACGGCGGTGTCTCAGGGG
AACAGCAACACGGTGGACGGAGAGAGCACAAGCGGAACTGAAGACATAAAGATTCAGTTC
AGCAGGTCAGGCAGTGGCAGTGGTGGGTTTCTTGAAGGACTATTTGGATGCTTAAGGCCT
GTATGGAATATCATTGGGAAGGCATATTCCACTGATTACAAATTGCAGCAGCAAGATACT
TGGGAAGTGCCATTTGAGGAGATCTCAGAGCTGCAGTGGCTGGGTAGTGGAGCCCAAGGA
GCGGTCTTCTTGGGCAAGTTCCGGGCGGAAGAGGTGGCCATCAAGAAAGTGAGAGAACAG
AATGAGACGGATATCAAGCATTTGAGGAAGTTGAAGCACCCTAACATCATCGCATTCAAG
GGTGTTTGTACTCAGGCCCCATGTTATTGTATTATCATGGAATACTGTGCCCATGGACAA
CTCTACGAGGTCTTACGAGCTGGCAGGAAGATCACACCTCGATTGCTAGTAGACTGGTCC
ACAGGAATTGCAAGTGGAATGAATTATTTGCACCTCCATAAAATTATTCATCGTGATCTC
AAATCACCTAATGTTTTAGTGACCCACACAGATGCGGTAAAAATTTCAGATTTTGGTACA
TCTAAGGAACTCAGTGACAAAAGTACCAAGATGTCATTTGCTGGCACGGTCGCATGGATG
GCGCCAGAGGTGATACGGAATGAACCTGTCTCTGAAAAAGTTGATATATGGTCTTTTGGA
GTGGTGCTTTGGGAGCTGCTGACAGGAGAGATCCCTTACAAAGATGTAGATTCTTCAGCC
ATTATCTGGGGTGTTGGAAGCAACAGCCTCCACCTTCCAGTTCCTTCCACTTGCCCTGAT
GGATTCAAAATCCTTATGAAACAGACGTGGCAGAGTAAACCTCGAAACCGACCTTCTTTT
CGGCAGACACTCATGCATTTAGACATTGCCTCTGCAGATGTACTTGCCACCCCACAAGAA
ACTTACTTCAAGTCTCAGGCTGAATGGAGAGAAGAAGTGAAAAAACATTTTGAGAAGATC
AAAAGTGAAGGAACTTGTATACACCGGTTAGATGAAGAACTGATTCGAAGGCGCAGAGAA
GAGCTCAGGCATGCGCTGGATATTCGTGAACACTATGAGCGGAAGCTTGAGCGGGCGAAT
AATTTATACATGGAATTGAGTGCCATCATGCTGCAGCTAGAAATGCGGGAGAAGGAGCTC
ATTAAGCGTGAGCAAGCAGTGGAAAAGAAGTATCCTGGGACCTACAAACGACACCCTGTT
CGTCCTATCATCCATCCCAATGCCATGGAGAAACTCATGAAAAGGAAAGGAGTGCCTCAC
AAATCTGGGATGCAGACCAAACGGCCAGACTTGTTGAGATCAGAAGGGATCCCCACCACA
GAAGTGGCTCCCACTGCATCCCCTTTGTCCGGAAGTCCCAAAATGTCCACTTCTAGCAGC
AAGAGCCGATATCGAAGCAAACCACGCCACCGCCGAGGGAATAGCAGAGGCAGCCATAGT
GACTTTGCCGCAATCTTGAAAAACCAGCCAGCCCAGGAAAATTCACCCCATCCCACTTAC
CTGCACCAAGCTCAATCCCAATACCCTTCTCTTCATCACCATAATTCTCTGCAGCAGCAA
TACCAGCAGCCCCCTCCTGCCATGTCCCAGAGTCACCATCCCAGACTCAATATGCACGGA
CAGGACATAGCAACCTGCGCCAACAACCTGAGGTATTTCGGCCCAGCAGCAGCCCTGCGG
AGCCCACTCAGCAACCATGCTCAGAGACAGCTGCCCGGCTCGAGCCCTGACCTCATCTCC
ACAGCCATGGCTGCAGACTGCTGGAGAAGTTCTGAGCCTGACAAGGGCCAAGCTGGTCCC
TGGGGCTGTTGCCAGGCTGACGCTTATGACCCCTGCCTTCAGTGCAGGCCAGAACAGTAT
GGGTCCTTAGACATACCCTCTGCTGAGCCAGTGGGGAGGAGCCCTGACCTTTCCAAGTCA
CCAGCACATAATCCTCTCTTGGAAAACGCCCAGAGTTCTGAGAAAACGGAAGAAAATGAA
TTCAGCGGCTGTAGGTCTGAGTCATCCCTCGGCACCTCTCATCTCGGCACCCCTCCAGCG
CTACCTCGAAAAACAAGGCCTCTGCAGAAGAGTGGAGATGACTCCTCAGAAGAGGAAGAA
GGGGAAGTAGATAGTGAAGTTGAATTTCCACGAAGACAGAGGCCCCATCGCTGTATCAGC
AGCTGCCAGTCATATTCAACCTTTAGCTCTGAGAATTTCTCTGTGTCTGATGGAGAAGAG
GGAAATACCAGTGACCACTCAAACAGTCCTGATGAGTTAGCTGATAAACTTGAAGACCGC
TTGGCAGAGAAGCTAGACGACCTGCTGTCCCAGACGCCAGAGATTCCCATTGACATATCC
TCACACTCGGATGGGCTCTCTGACAAGGAGTGTGCCGTGCGCCGTGTGAAGACTCAGATG
TCTCTGGGCAAGCTGTGTGTGGAGGAACGTGGCTATGAGAACCCCATGCAGTTTGAAGAA
TCGGACTGTGACTCTTCAGATGGGGAGTGTTCTGATGCCACAGTTAGGACCAATAAACAC
TACAGCTCTGCTACCTGGTAA
Chromosome Location
3
Locus
3q27.2
External Identifiers
ResourceLink
UniProtKB IDO43283
UniProtKB Entry NameM3K13_HUMAN
HGNC IDHGNC:6852
General References
  1. Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T: Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. J Biol Chem. 1997 Nov 7;272(45):28622-9. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Schultz SJ, Nigg EA: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. Cell Growth Differ. 1993 Oct;4(10):821-30. [Article]
  6. Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T: Identification and characterization of functional domains in a mixed lineage kinase LZK. FEBS Lett. 2001 Jan 19;488(3):190-5. [Article]
  7. Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T: Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. J Biochem. 2001 Dec;130(6):773-81. [Article]
  8. Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T: Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Eur J Biochem. 2003 Jan;270(1):76-83. [Article]
  9. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails