E3 ubiquitin-protein ligase TRIM13

Details

Name
E3 ubiquitin-protein ligase TRIM13
Synonyms
  • 6.3.2.-
  • B-cell chronic lymphocytic leukemia tumor suppressor Leu5
  • LEU5
  • Leukemia-associated protein 5
  • Putative tumor suppressor RFP2
  • Ret finger protein 2
  • RFP2
  • RING finger protein 77
  • RNF77
  • Tripartite motif-containing protein 13
Gene Name
TRIM13
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002117|E3 ubiquitin-protein ligase TRIM13
MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGILEGSVRNSLWRPAPFKCPTCRKE
TSATGINSLQVNYSLKGIVEKYNKIKISPKMPVCKGHLGQPLNIFCLTDMQLICGICATR
GEHTKHVFCSIEDAYAQERDAFESLFQSFETWRRGDALSRLDTLETSKRKSLQLLTKDSD
KVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQAYDPEINKLNTILQEQRMAFNIAEAFK
DVSEPIVFLQQMQEFREKIKVIKETPLPPSNLPASPLMKNFDTSQWEDIKLVDVDKLSLP
QDTGTFISKIPWSFYKLFLLILLLGLVIVFGPTMFLEWSLFDDLATWKGCLSNFSSYLTK
TADFIEQSVFYWEQVTDGFFIFNERFKNFTLVVLNNVAEFVCKYKLL
Number of residues
407
Molecular Weight
46987.08
Theoretical pI
5.8
GO Classification
Functions
ligase activity / signal transducer activity / ubiquitin-protein transferase activity / zinc ion binding
Processes
anatomical structure morphogenesis / ER-associated ubiquitin-dependent protein catabolic process / innate immune response / negative regulation of viral release from host cell / negative regulation of viral transcription / positive regulation of cell death / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of macroautophagy / positive regulation of NF-kappaB transcription factor activity / proteasome-mediated ubiquitin-dependent protein catabolic process / protein autoubiquitination / response to gamma radiation / signal transduction
Components
cytoplasm / endoplasmic reticulum membrane / integral component of membrane / perinuclear endoplasmic reticulum
General Function
Zinc ion binding
Specific Function
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
Pfam Domain Function
Transmembrane Regions
317-337
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0010745|E3 ubiquitin-protein ligase TRIM13 (TRIM13)
ATGGATGTGATGGAGCTGCTTGAAGAAGATCTCACATGCCCTATTTGTTGTAGTCTGTTT
GATGATCCACGGGTTTTGCCTTGCTCCCACAACTTCTGCAAAAAATGCTTAGAAGGTATC
TTAGAAGGGAGTGTGCGGAATTCCTTGTGGAGACCAGCTCCATTCAAGTGTCCTACATGC
CGTAAGGAAACTTCAGCTACTGGAATTAATAGCCTGCAGGTTAATTACTCCCTGAAGGGT
ATTGTGGAAAAGTATAACAAGATCAAGATCTCTCCCAAAATGCCAGTATGCAAAGGACAC
TTGGGGCAGCCTCTCAACATTTTCTGCCTGACTGATATGCAGCTGATTTGTGGGATCTGT
GCTACTCGTGGGGAGCACACCAAACATGTCTTCTGTTCTATTGAAGATGCCTATGCTCAG
GAAAGGGATGCCTTTGAGTCCCTCTTCCAGAGCTTTGAGACCTGGCGTCGGGGAGATGCT
CTTTCTCGCTTGGATACCTTGGAAACTAGTAAGAGGAAATCCCTACAGTTACTGACTAAA
GATTCAGATAAAGTGAAGGAATTTTTTGAGAAGTTACAACACACACTGGATCAAAAGAAG
AATGAAATTCTGTCTGACTTTGAGACCATGAAACTTGCTGTTATGCAAGCATATGACCCA
GAGATCAACAAACTCAACACCATCTTGCAGGAGCAACGGATGGCCTTTAACATTGCTGAG
GCTTTCAAAGATGTGTCAGAACCCATTGTATTTCTGCAACAGATGCAGGAGTTTAGAGAG
AAAATCAAAGTAATCAAGGAAACTCCTTTACCTCCCTCTAATTTGCCTGCAAGCCCTTTA
ATGAAGAACTTTGATACCAGTCAGTGGGAAGACATAAAACTAGTCGATGTGGATAAACTT
TCTTTGCCTCAAGACACTGGCACATTCATTAGCAAGATTCCCTGGAGCTTTTATAAGTTA
TTTTTGCTAATCCTTCTGCTTGGCCTTGTCATTGTCTTTGGTCCTACCATGTTCCTAGAA
TGGTCATTATTTGATGACCTGGCAACTTGGAAAGGCTGTCTTTCAAACTTCAGTTCCTAT
CTGACTAAAACAGCCGATTTCATAGAACAATCAGTTTTTTACTGGGAACAGGTGACAGAT
GGGTTTTTCATTTTCAATGAAAGATTCAAGAATTTTACTTTGGTGGTACTGAACAATGTG
GCAGAATTTGTGTGCAAATATAAACTATTATAA
Chromosome Location
13
Locus
13q14
External Identifiers
ResourceLink
UniProtKB IDO60858
UniProtKB Entry NameTRI13_HUMAN
GenBank Protein ID3133092
GenBank Gene IDAJ224819
GenAtlas IDTRIM13
HGNC IDHGNC:9976
General References
  1. Kapanadze B, Kashuba V, Baranova A, Rasool O, van Everdink W, Liu Y, Syomov A, Corcoran M, Poltaraus A, Brodyansky V, Syomova N, Kazakov A, Ibbotson R, van den Berg A, Gizatullin R, Fedorova L, Sulimova G, Zelenin A, Deaven L, Lehrach H, Grander D, Buys C, Oscier D, Zabarovsky ER, Einhorn S, Yankovsky N: A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5. FEBS Lett. 1998 Apr 17;426(2):266-70. [Article]
  2. Migliazza A, Bosch F, Komatsu H, Cayanis E, Martinotti S, Toniato E, Guccione E, Qu X, Chien M, Murty VV, Gaidano G, Inghirami G, Zhang P, Fischer S, Kalachikov SM, Russo J, Edelman I, Efstratiadis A, Dalla-Favera R: Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood. 2001 Apr 1;97(7):2098-104. [Article]
  3. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A: The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51. [Article]
  4. van Everdink WJ, Baranova A, Lummen C, Tyazhelova T, Looman MW, Ivanov D, Verlind E, Pestova A, Faber H, van der Veen AY, Yankovsky N, Vellenga E, Buys CH: RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2003 Oct 1;146(1):48-57. [Article]
  5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  6. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [Article]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  8. Lerner M, Corcoran M, Cepeda D, Nielsen ML, Zubarev R, Ponten F, Uhlen M, Hober S, Grander D, Sangfelt O: The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. Mol Biol Cell. 2007 May;18(5):1670-82. Epub 2007 Feb 21. [Article]
  9. Joo HM, Kim JY, Jeong JB, Seong KM, Nam SY, Yang KH, Kim CS, Kim HS, Jeong M, An S, Jin YW: Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. Eur J Cell Biol. 2011 May;90(5):420-31. doi: 10.1016/j.ejcb.2010.12.001. Epub 2011 Feb 17. [Article]
  10. Tomar D, Singh R, Singh AK, Pandya CD, Singh R: TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells. Biochim Biophys Acta. 2012 Feb;1823(2):316-26. doi: 10.1016/j.bbamcr.2011.11.015. Epub 2011 Dec 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01497Etorphineillicit, vet_approvedunknownagonistDetails
DB01548Diprenorphineillicit, vet_approvedunknownDetails
DB01565Dihydromorphineexperimental, illicitunknownagonistDetails