Short-chain dehydrogenase/reductase 3

Details

Name
Short-chain dehydrogenase/reductase 3
Synonyms
  • 1.1.1.300
  • DD83.1
  • RDH17
  • Retinal short-chain dehydrogenase/reductase 1
  • Retinol dehydrogenase 17
  • retSDR1
  • SDR16C1
  • Short chain dehydrogenase/reductase family 16C member 1
Gene Name
DHRS3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004554|Short-chain dehydrogenase/reductase 3
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP
LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG
RT
Number of residues
302
Molecular Weight
33548.115
Theoretical pI
9.08
GO Classification
Functions
electron carrier activity / NADP-retinol dehydrogenase activity / nucleotide binding / retinol dehydrogenase activity
Processes
bone morphogenesis / cardiac septum morphogenesis / negative regulation of retinoic acid receptor signaling pathway / outflow tract morphogenesis / palate development / phototransduction, visible light / regulation of ossification / retinoid metabolic process / retinol metabolic process / visual perception
Components
endoplasmic reticulum membrane / integral component of membrane / photoreceptor outer segment membrane
General Function
Retinol dehydrogenase activity
Specific Function
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Pfam Domain Function
Transmembrane Regions
9-29 170-190 195-215 253-273
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0019271|Short-chain dehydrogenase/reductase 3 (DHRS3)
ATGGTGTGGAAACGGCTGGGCGCGCTGGTGATGTTCCCTCTACAGATGATCTATCTGGTG
GTGAAAGCAGCCGTCGGACTGGTGCTGCCCGCCAAGCTGCGGGACCTGTCGCGGGAGAAC
GTCCTCATCACCGGCGGCGGGAGAGGCATCGGGCGTCAGCTCGCCCGCGAGTTCGCGGAG
CGCGGCGCCAGAAAGATTGTTCTCTGGGGCCGGACTGAGAAATGCCTGAAGGAGACGACG
GAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGTGGGCAACCGG
GAGGAGGTGTACCAGACGGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTG
GTGAACAATGCCGCCGTGGTCCATGGGAAGAGCCTAATGGACAGTGATGATGATGCCCTC
CTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGCCTTCCTGCCG
CGTATGCTGGAGCTGCAGAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCT
GCCATCCCCGGTGCCATCGACTACTGCACATCCAAAGCGTCAGCCTTCGCCTTCATGGAG
AGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGTGCTGCCCTTC
CACACCAGCACCGAGATGTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCA
CTGAAGCCGGAGACGGTGGCCCGGAGGACAGTGGAAGCTGTGCAGCTCAACCAGGCCCTC
CTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACTTCCACAGGCT
GCACTCGAGGAGATCCACAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGG
CGGACATAG
Chromosome Location
1
Locus
1p36.1
External Identifiers
ResourceLink
UniProtKB IDO75911
UniProtKB Entry NameDHRS3_HUMAN
GenBank Protein ID3450828
GenBank Gene IDAF061741
GenAtlas IDDHRS3
HGNC IDHGNC:17693
General References
  1. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K: Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21;273(34):21790-9. [Article]
  2. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00162Vitamin Aapproved, nutraceutical, vet_approvedunknownsubstrateDetails