Short-chain dehydrogenase/reductase 3
Details
- Name
- Short-chain dehydrogenase/reductase 3
- Synonyms
- 1.1.1.300
- DD83.1
- RDH17
- Retinal short-chain dehydrogenase/reductase 1
- Retinol dehydrogenase 17
- retSDR1
- SDR16C1
- Short chain dehydrogenase/reductase family 16C member 1
- Gene Name
- DHRS3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004554|Short-chain dehydrogenase/reductase 3 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG RT
- Number of residues
- 302
- Molecular Weight
- 33548.115
- Theoretical pI
- 9.08
- GO Classification
- Functionselectron carrier activity / NADP-retinol dehydrogenase activity / nucleotide binding / retinol dehydrogenase activityProcessesbone morphogenesis / cardiac septum morphogenesis / negative regulation of retinoic acid receptor signaling pathway / outflow tract morphogenesis / palate development / phototransduction, visible light / regulation of ossification / retinoid metabolic process / retinol metabolic process / visual perceptionComponentsendoplasmic reticulum membrane / integral component of membrane / photoreceptor outer segment membrane
- General Function
- Retinol dehydrogenase activity
- Specific Function
- Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- 9-29 170-190 195-215 253-273
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0019271|Short-chain dehydrogenase/reductase 3 (DHRS3) ATGGTGTGGAAACGGCTGGGCGCGCTGGTGATGTTCCCTCTACAGATGATCTATCTGGTG GTGAAAGCAGCCGTCGGACTGGTGCTGCCCGCCAAGCTGCGGGACCTGTCGCGGGAGAAC GTCCTCATCACCGGCGGCGGGAGAGGCATCGGGCGTCAGCTCGCCCGCGAGTTCGCGGAG CGCGGCGCCAGAAAGATTGTTCTCTGGGGCCGGACTGAGAAATGCCTGAAGGAGACGACG GAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGTGGGCAACCGG GAGGAGGTGTACCAGACGGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTG GTGAACAATGCCGCCGTGGTCCATGGGAAGAGCCTAATGGACAGTGATGATGATGCCCTC CTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGCCTTCCTGCCG CGTATGCTGGAGCTGCAGAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCT GCCATCCCCGGTGCCATCGACTACTGCACATCCAAAGCGTCAGCCTTCGCCTTCATGGAG AGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGTGCTGCCCTTC CACACCAGCACCGAGATGTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCA CTGAAGCCGGAGACGGTGGCCCGGAGGACAGTGGAAGCTGTGCAGCTCAACCAGGCCCTC CTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACTTCCACAGGCT GCACTCGAGGAGATCCACAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGG CGGACATAG
- Chromosome Location
- 1
- Locus
- 1p36.1
- External Identifiers
Resource Link UniProtKB ID O75911 UniProtKB Entry Name DHRS3_HUMAN GenBank Protein ID 3450828 GenBank Gene ID AF061741 GenAtlas ID DHRS3 HGNC ID HGNC:17693 - General References
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