Ornithine decarboxylase antizyme 2
Details
- Name
- Ornithine decarboxylase antizyme 2
- Synonyms
- AZ2
- Gene Name
- OAZ2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004383|Ornithine decarboxylase antizyme 2 MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKD EKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLL ALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYP LDQNLSDED
- Number of residues
- 189
- Molecular Weight
- 21010.94
- Theoretical pI
- 5.03
- GO Classification
- Functionsornithine decarboxylase inhibitor activityProcessescellular nitrogen compound metabolic process / negative regulation of polyamine transmembrane transport / polyamine biosynthetic process / polyamine metabolic process / positive regulation of intracellular protein transport / positive regulation of protein catabolic process / regulation of cellular amino acid metabolic process / small molecule metabolic processComponentscytosol / nucleus
- General Function
- Ornithine decarboxylase inhibitor activity
- Specific Function
- Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
- Pfam Domain Function
- ODC_AZ (PF02100)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0004382|570 bp ATGATAAACACCCAGGACAGTAGTATTTTGCCTTTGAGTAACTGTCCCCAGCTCCAGTGC TGCAGGCACATTGTTCCAGGGCCTCTGTGGTGCTCCGATGCCCCTCACCCACTGTCGAAG ATCCCCGGTGGGCGAGGGGGCGGCAGGGATCCTTCTCTCTCAGCTCTAATATATAAGGAC GAGAAGCTCACTGTGACCCAGGACCTCCCTGTGAATGATGGAAAACCTCACATCGTCCAC TTCCAGTATGAGGTCACCGAGGTGAAGGTCTCTTCTTGGGATGCAGTCCTGTCCAGCCAG AGCCTGTTTGTAGAAATCCCAGATGGATTATTAGCTGATGGGAGCAAAGAAGGATTGTTA GCACTGCTAGAGTTTGCTGAAGAGAAGATGAAAGTGAACTATGTCTTCATCTGCTTCAGG AAGGGCCGAGAAGACAGAGCTCCACTCCTGAAGACCTTCAGCTTCTTGGGCTTTGAGATT GTACGTCCAGGCCATCCCTGTGTCCCCTCTCGGCCAGATGTGATGTTCATGGTTTATCCC CTGGACCAGAACTTGTCCGATGAGGACTAA
- Chromosome Location
- Not Available
- Locus
- 15q22.31
- External Identifiers
Resource Link UniProtKB ID O95190 UniProtKB Entry Name OAZ2_HUMAN GenBank Protein ID 3766170 GenBank Gene ID AF057297 GenAtlas ID OAZ2 HGNC ID HGNC:8096 - General References
- Ivanov IP, Gesteland RF, Atkins JF: A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Genomics. 1998 Sep 1;52(2):119-29. [Article]
- Zhou J, Atkins JF, Gesteland RF: Structure of human ornithine decarboxylase antizyme 2 gene. Gene. 1999 May 31;232(2):165-71. [Article]
- Kanerva K, Makitie LT, Pelander A, Heiskala M, Andersson LC: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Biochem J. 2008 Jan 1;409(1):187-92. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details