Ornithine decarboxylase antizyme 2

Details

Name
Ornithine decarboxylase antizyme 2
Synonyms
  • AZ2
Gene Name
OAZ2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004383|Ornithine decarboxylase antizyme 2
MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKD
EKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLL
ALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYP
LDQNLSDED
Number of residues
189
Molecular Weight
21010.94
Theoretical pI
5.03
GO Classification
Functions
ornithine decarboxylase inhibitor activity
Processes
cellular nitrogen compound metabolic process / negative regulation of polyamine transmembrane transport / polyamine biosynthetic process / polyamine metabolic process / positive regulation of intracellular protein transport / positive regulation of protein catabolic process / regulation of cellular amino acid metabolic process / small molecule metabolic process
Components
cytosol / nucleus
General Function
Ornithine decarboxylase inhibitor activity
Specific Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0004382|570 bp
ATGATAAACACCCAGGACAGTAGTATTTTGCCTTTGAGTAACTGTCCCCAGCTCCAGTGC
TGCAGGCACATTGTTCCAGGGCCTCTGTGGTGCTCCGATGCCCCTCACCCACTGTCGAAG
ATCCCCGGTGGGCGAGGGGGCGGCAGGGATCCTTCTCTCTCAGCTCTAATATATAAGGAC
GAGAAGCTCACTGTGACCCAGGACCTCCCTGTGAATGATGGAAAACCTCACATCGTCCAC
TTCCAGTATGAGGTCACCGAGGTGAAGGTCTCTTCTTGGGATGCAGTCCTGTCCAGCCAG
AGCCTGTTTGTAGAAATCCCAGATGGATTATTAGCTGATGGGAGCAAAGAAGGATTGTTA
GCACTGCTAGAGTTTGCTGAAGAGAAGATGAAAGTGAACTATGTCTTCATCTGCTTCAGG
AAGGGCCGAGAAGACAGAGCTCCACTCCTGAAGACCTTCAGCTTCTTGGGCTTTGAGATT
GTACGTCCAGGCCATCCCTGTGTCCCCTCTCGGCCAGATGTGATGTTCATGGTTTATCCC
CTGGACCAGAACTTGTCCGATGAGGACTAA
Chromosome Location
Not Available
Locus
15q22.31
External Identifiers
ResourceLink
UniProtKB IDO95190
UniProtKB Entry NameOAZ2_HUMAN
GenBank Protein ID3766170
GenBank Gene IDAF057297
GenAtlas IDOAZ2
HGNC IDHGNC:8096
General References
  1. Ivanov IP, Gesteland RF, Atkins JF: A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Genomics. 1998 Sep 1;52(2):119-29. [Article]
  2. Zhou J, Atkins JF, Gesteland RF: Structure of human ornithine decarboxylase antizyme 2 gene. Gene. 1999 May 31;232(2):165-71. [Article]
  3. Kanerva K, Makitie LT, Pelander A, Heiskala M, Andersson LC: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Biochem J. 2008 Jan 1;409(1):187-92. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails