Cytochrome P450 2B1

Details

Name
Cytochrome P450 2B1
Synonyms
  • 1.14.14.1
  • Cyp2b-1
  • CYPIIB1
  • Cytochrome P450-B
  • Cytochrome P450-LM2
  • Cytochrome P450-PB1
  • Cytochrome P450-PB2
  • Cytochrome P450b
Gene Name
Cyp2b1
Organism
Rat
Amino acid sequence
>lcl|BSEQ0017527|Cytochrome P450 2B1
MEPTILLLLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDRGGLLNSFMQLRE
KYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGER
WKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIIC
SIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGFLKYFPGAHRQISKNLQE
ILDYIGHIVEKHRATLDPSAPRDFIDTYLLRMEKEKSNHHTEFHHENLMISLLSLFFAGT
ETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRSKMPYTDAVIHEIQRFS
DLVPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDSFNPEHFLDANGAL
KKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSSHLAPKDIDLTPKESGIGKI
PPTYQICFSAR
Number of residues
491
Molecular Weight
55933.06
Theoretical pI
Not Available
GO Classification
Functions
arachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activity
Processes
drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / response to calcium ion / response to drug / response to insulin / response to metal ion / response to organic cyclic compound / response to sulfur dioxide / xenobiotic metabolic process
Components
cytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP00176
UniProtKB Entry NameCP2B1_RAT
General References
  1. Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y: Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver. Proc Natl Acad Sci U S A. 1983 Jul;80(13):3958-62. [Article]
  2. Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y: Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver. J Biol Chem. 1985 Jul 5;260(13):7980-4. [Article]
  3. Fujii-Kuriyama Y, Mizukami Y, Kawajiri K, Sogawa K, Muramatsu M: Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver. Proc Natl Acad Sci U S A. 1982 May;79(9):2793-7. [Article]
  4. Oesch F, Waxman DJ, Morrissey JJ, Honscha W, Kissel W, Friedberg T: Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. Arch Biochem Biophys. 1989 Apr;270(1):23-32. [Article]
  5. Botelho LH, Ryan DE, Levin W: Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene. J Biol Chem. 1979 Jul 10;254(13):5635-40. [Article]
  6. Roberts ES, Hopkins NE, Zaluzec EJ, Gage DA, Alworth WL, Hollenberg PF: Identification of active-site peptides from 3H-labeled 2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry. Biochemistry. 1994 Mar 29;33(12):3766-71. [Article]
  7. Pyerin W, Taniguchi H: Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450. EMBO J. 1989 Oct;8(10):3003-10. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00869DorzolamideapprovednosubstrateDetails
DB00409Remoxiprideapproved, withdrawnunknowninhibitorDetails