Superoxide dismutase [Cu-Zn]

Details

Name
Superoxide dismutase [Cu-Zn]
Synonyms
  • 1.15.1.1
  • hSod1
  • Superoxide dismutase 1
Gene Name
SOD1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0021851|Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Number of residues
154
Molecular Weight
15935.685
Theoretical pI
6.07
GO Classification
Functions
chaperone binding / copper ion binding / identical protein binding / protein homodimerization activity / protein phosphatase 2B binding / Rac GTPase binding / superoxide dismutase activity / zinc ion binding
Processes
activation of MAPK activity / anterograde axon cargo transport / auditory receptor cell stereocilium organization / blood coagulation / cell aging / cellular iron ion homeostasis / cellular response to ATP / cellular response to cadmium ion / cellular response to potassium ion / embryo implantation / glutathione metabolic process / heart contraction / hydrogen peroxide biosynthetic process / locomotory behavior / muscle cell cellular homeostasis / myeloid cell homeostasis / negative regulation of cholesterol biosynthetic process / negative regulation of neuron apoptotic process / neurofilament cytoskeleton organization / ovarian follicle development / peripheral nervous system myelin maintenance / placenta development / platelet activation / platelet degranulation / positive regulation of apoptotic process / positive regulation of catalytic activity / positive regulation of cytokine production / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of superoxide anion generation / reactive oxygen species metabolic process / regulation of blood pressure / regulation of GTPase activity / regulation of mitochondrial membrane potential / regulation of multicellular organism growth / regulation of organ growth / regulation of protein kinase activity / regulation of T cell differentiation in thymus / relaxation of vascular smooth muscle / removal of superoxide radicals / response to amphetamine / response to antibiotic / response to antipsychotic drug / response to axon injury / response to carbon monoxide / response to copper ion / response to drug / response to ethanol / response to heat / response to hydrogen peroxide / response to nutrient levels / response to organic substance / response to reactive oxygen species / response to superoxide / retina homeostasis / retrograde axon cargo transport / sensory perception of sound / spermatogenesis / superoxide anion generation / superoxide metabolic process / thymus development / transmission of nerve impulse
Components
cytoplasm / cytoplasmic vesicle / cytosol / dendrite cytoplasm / dense core granule / extracellular exosome / extracellular matrix / extracellular region / extracellular space / lysosome / mitochondrial intermembrane space / mitochondrial matrix / mitochondrion / myelin sheath / neuronal cell body / nucleoplasm / nucleus / peroxisome / protein complex
General Function
Zinc ion binding
Specific Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021852|Superoxide dismutase [Cu-Zn] (SOD1)
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
Chromosome Location
21
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP00441
UniProtKB Entry NameSODC_HUMAN
GenBank Gene IDL44139
GenAtlas IDSOD1
HGNC IDHGNC:11179
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05025ArimoclomolinvestigationalunknownDetails
DB03382S-oxy-L-cysteineexperimentalunknownDetails
DB00163Vitamin Eapproved, nutraceutical, vet_approvedunknowninducerDetails
DB00515CisplatinapprovedunknownsubstrateDetails
DB00958CarboplatinapprovedunknowninhibitorDetails
DB00526Oxaliplatinapproved, investigationalnosubstrateDetails
DB09130Copperapproved, investigationalunknowncofactorDetails
DB01593Zincapproved, investigationalunknownDetails
DB016295-fluorouridineexperimentalunknownDetails
DB00988DopamineapprovedunknownDetails
DB01064Isoprenalineapproved, investigationalunknownstabilizationDetails
DB09221PolaprezincexperimentalunknowninducerDetails
DB14001alpha-Tocopherol succinateapproved, nutraceutical, vet_approvedunknowninducerDetails
DB14002D-alpha-Tocopherol acetateapproved, nutraceutical, vet_approvedunknowninducerDetails
DB14009Medical Cannabisexperimental, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownligandDetails
DB14533Zinc chlorideapproved, investigationalunknowncofactorDetails
DB14533Zinc chlorideapproved, investigationalunknowncofactorDetails
DB09061Cannabidiolapproved, investigationalunknowninhibitorDetails
DB14009Medical Cannabisexperimental, investigationalunknowninhibitorDetails
DB14011NabiximolsinvestigationalunknowninhibitorDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknowncofactorDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknowncofactorDetails
DB09096Benzoyl peroxideapprovedunknowninhibitorDetails