Alpha-amylase

Details

Name
Alpha-amylase
Synonyms
  • 1,4-alpha-D-glucan glucanohydrolase
  • 3.2.1.1
  • amyA
Gene Name
amyE
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0010970|Alpha-amylase
MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTAPSIKSGTILHAWNWSF
NTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWLYQPTSYQIGNRYLGTEQE
FKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPNWTHGNTQIKNWSDRWDVTQN
SLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDAAKHIELPDDGSYGSQFWPNITN
TSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSIRSALKNRNLGVSNISHYASDVSAD
KLVTWVESHDTYANDDEESTWMSDDDIRLGWAVIASRSGSTPLFFSRPEGGGNGVRFPGK
SQIGDRGSALFEDQAITAVNRFHNVMAGQPEELSNPNGNNQIFMNQRGSHGVVLANAGSS
SVSINTATKLPDGRYDNKAGAGSFQVNDGKLTGTINARSVAVLYPDDIAKAPHVFLENYK
TGVTHSFNDQLTITLRADANTTKAVYQINNGPETAFKDGDQFTIGKGDPFGKTYTIMLKG
TNSDGVTRTEKYSFVKRDPASAKTIGYQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPM
TKNADGIYTLTLPADTDTTNAKVIFNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH
Number of residues
659
Molecular Weight
72377.4
Theoretical pI
6.27
GO Classification
Functions
alpha-amylase activity / metal ion binding
Processes
carbohydrate metabolic process
Components
extracellular region
General Function
Metal ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010971|Alpha-amylase (amyE)
ATGTTTGCAAAACGATTCAAAACCTCTTTACTGCCGTTATTCGCTGGATTTTTATTGCTG
TTTCATTTGGTTCTGGCAGGACCGGCGGCTGCGAGTGCTGAAACGGCGAACAAATCGAAT
GAGCTTACAGCACCGTCGATCAAAAGCGGAACCATTCTTCATGCATGGAATTGGTCGTTC
AATACGTTAAAACACAATATGAAGGATATTCATGATGCAGGATATACAGCCATTCAGACA
TCTCCGATTAACCAAGTAAAGGAAGGGAATCAAGGAGATAAAAGCATGTCGAACTGGTAC
TGGCTGTATCAGCCGACATCGTATCAAATTGGCAACCGTTACTTAGGTACTGAACAAGAA
TTTAAAGAAATGTGTGCAGCCGCTGAAGAATATGGCATAAAGGTCATTGTTGACGCGGTC
ATCAATCATACCACCAGTGATTATGCCGCGATTTCCAATGAGGTTAAGAGTATTCCAAAC
TGGACACATGGAAACACACAAATTAAAAACTGGTCTGATCGATGGGATGTCACGCAGAAT
TCATTGCTCGGGCTGTATGACTGGAATACACAAAATACACAAGTACAGTCCTATCTGAAA
CGGTTCTTAGACAGGGCATTGAATGACGGGGCAGACGGTTTTCGATTTGATGCCGCCAAA
CATATAGAGCTTCCAGATGATGGCAGTTACGGCAGTCAATTTTGGCCGAATATCACAAAT
ACATCTGCAGAGTTCCAATACGGAGAAATCCTGCAGGATAGTGCCTCCAGAGATGCTGCA
TATGCGAATTATATGGATGTGACAGCGTCTAACTATGGGCATTCCATAAGGTCCGCTTTA
AAGAATCGTAATCTGGGCGTGTCGAATATCTCCCACTATGCATCTGATGTGTCTGCGGAC
AAGCTAGTGACATGGGTAGAGTCGCATGATACGTATGCCAATGATGATGAAGAGTCGACA
TGGATGAGCGATGATGATATCCGTTTAGGCTGGGCGGTGATAGCTTCTCGTTCAGGCAGT
ACGCCTCTTTTCTTTTCCAGACCTGAGGGAGGCGGAAATGGTGTGAGGTTCCCGGGGAAA
AGCCAAATAGGCGATCGCGGGAGTGCTTTATTTGAAGATCAGGCTATCACTGCGGTCAAT
AGATTTCACAATGTGATGGCTGGACAGCCTGAGGAACTCTCGAACCCGAATGGAAACAAC
CAGATATTTATGAATCAGCGCGGCTCACATGGCGTTGTGCTGGCAAATGCAGGTTCATCC
TCTGTCTCTATCAATACGGCAACAAAATTGCCTGATGGCAGGTATGACAATAAAGCTGGA
GCGGGTTCATTTCAAGTGAACGATGGTAAACTGACAGGCACGATCAATGCCAGGTCTGTA
GCTGTGCTTTATCCTGATGATATTGCAAAAGCGCCTCATGTTTTCCTTGAGAATTACAAA
ACAGGTGTAACACATTCTTTCAATGATCAACTGACGATTACCTTGCGTGCAGATGCGAAT
ACAACAAAAGCCGTTTATCAAATCAATAATGGACCAGAGACGGCGTTTAAGGATGGAGAT
CAATTCACAATCGGAAAAGGAGATCCATTTGGCAAAACATACACCATCATGTTAAAAGGA
ACGAACAGTGATGGTGTAACGAGGACCGAGAAATACAGTTTTGTTAAAAGAGATCCAGCG
TCGGCCAAAACCATCGGCTATCAAAATCCGAATCATTGGAGCCAGGTAAATGCTTATATC
TATAAACATGATGGGAGCCGAGTAATTGAATTGACCGGATCTTGGCCTGGAAAACCAATG
ACTAAAAATGCAGACGGAATTTACACGCTGACGCTGCCTGCGGACACGGATACAACCAAC
GCAAAAGTGATTTTTAATAATGGCAGCGCCCAAGTGCCCGGTCAGAATCAGCCTGGCTTT
GATTACGTGCTAAATGGTTTATATAATGACTCGGGCTTAAGCGGTTCTCTTCCCCATTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP00691
UniProtKB Entry NameAMY_BACSU
GenBank Protein ID39794
GenBank Gene IDV00101
General References
  1. Yang M, Galizzi A, Henner D: Nucleotide sequence of the amylase gene from Bacillus subtilis. Nucleic Acids Res. 1983 Jan 25;11(2):237-49. [Article]
  2. Yamane K, Hirata Y, Furusato T, Yamazaki H, Nakayama A: Changes in the properties and molecular weights of Bacillus subtilis M-type and N-type alpha-amylases resulting from a spontaneous deletion. J Biochem. 1984 Dec;96(6):1849-58. [Article]
  3. Yamane K, Kumano M, Kurita K: The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes. Microbiology. 1996 Nov;142 ( Pt 11):3047-56. [Article]
  4. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  5. Barbe V, Cruveiller S, Kunst F, Lenoble P, Meurice G, Sekowska A, Vallenet D, Wang T, Moszer I, Medigue C, Danchin A: From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Microbiology. 2009 Jun;155(Pt 6):1758-75. doi: 10.1099/mic.0.027839-0. Epub 2009 Apr 21. [Article]
  6. Yamazaki H, Ohmura K, Nakayama A, Takeichi Y, Otozai K, Yamasaki M, Tamura G, Yamane K: Alpha-amylase genes (amyR2 and amyE+) from an alpha-amylase-hyperproducing Bacillus subtilis strain: molecular cloning and nucleotide sequences. J Bacteriol. 1983 Oct;156(1):327-37. [Article]
  7. Ohmura K, Yamazaki H, Takeichi Y, Nakayama A, Otozai K, Yamane K, Yamasaki M, Tamura G: Nucleotide sequence of the promoter and NH2-terminal signal peptide region of Bacillus subtilis alpha-amylase gene cloned in pUB110. Biochem Biophys Res Commun. 1983 Apr 29;112(2):678-83. [Article]
  8. Mantsala P, Zalkin H: Membrane-bound and soluble extracellular alpha-amylase from Bacillus subtilis. J Biol Chem. 1979 Sep 10;254(17):8540-7. [Article]
  9. Fujimoto Z, Takase K, Doui N, Momma M, Matsumoto T, Mizuno H: Crystal structure of a catalytic-site mutant alpha-amylase from Bacillus subtilis complexed with maltopentaose. J Mol Biol. 1998 Mar 27;277(2):393-407. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB018414,6-DideoxyglucoseexperimentalunknownDetails
DB021206-Amino-4-Hydroxymethyl-Cyclohex-4-Ene-1,2,3-TriolexperimentalunknownDetails
DB02379Beta-D-GlucoseexperimentalunknownDetails