Alpha-1-antitrypsin
Details
- Name
- Alpha-1-antitrypsin
- Synonyms
- AAT
- Alpha-1 protease inhibitor
- Alpha-1-antiproteinase
- PI
- Serpin A1
- Gene Name
- SERPINA1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001896|Alpha-1-antitrypsin MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFS LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF QELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQ INDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTV KVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFL ENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKA VLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
- Number of residues
- 418
- Molecular Weight
- 46736.195
- Theoretical pI
- 5.31
- GO Classification
- Functionsglycoprotein binding / identical protein binding / protease binding / serine-type endopeptidase inhibitor activityProcessesacute-phase response / blood coagulation / cellular protein metabolic process / COPII vesicle coating / ER to Golgi vesicle-mediated transport / membrane organization / negative regulation of endopeptidase activity / platelet activation / platelet degranulation / post-translational protein modification / protein N-linked glycosylation via asparagineComponentsendoplasmic reticulum / endoplasmic reticulum lumen / endoplasmic reticulum-Golgi intermediate compartment membrane / ER to Golgi transport vesicle / extracellular exosome / extracellular region / extracellular space / Golgi apparatus / Golgi membrane / platelet alpha granule lumen / proteinaceous extracellular matrix
- General Function
- Serine-type endopeptidase inhibitor activity
- Specific Function
- Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
- Pfam Domain Function
- Serpin (PF00079)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0020495|Alpha-1-antitrypsin (SERPINA1) ATGCCGTCTTCTGTCTCGTGGGGCATCCTCCTGCTGGCAGGCCTGTGCTGCCTGGTCCCT GTCTCCCTGGCTGAGGATCCCCAGGGAGATGCTGCCCAGAAGACAGATACATCCCACCAT GATCAGGATCACCCAACCTTCAACAAGATCACCCCCAACCTGGCTGAGTTCGCCTTCAGC CTATACCGCCAGCTGGCACACCAGTCCAACAGCACCAATATCTTCTTCTCCCCAGTGAGC ATCGCTACAGCCTTTGCAATGCTCTCCCTGGGGACCAAGGCTGACACTCACGATGAAATC CTGGAGGGCCTGAATTTCAACCTCACGGAGATTCCGGAGGCTCAGATCCATGAAGGCTTC CAGGAACTCCTCCGTACCCTCAACCAGCCAGACAGCCAGCTCCAGCTGACCACCGGCAAT GGCCTGTTCCTCAGCGAGGGCCTGAAGCTAGTGGATAAGTTTTTGGAGGATGTTAAAAAG TTGTACCACTCAGAAGCCTTCACTGTCAACTTCGGGGACACCGAAGAGGCCAAGAAACAG ATCAACGATTACGTGGAGAAGGGTACTCAAGGGAAAATTGTGGATTTGGTCAAGGAGCTT GACAGAGACACAGTTTTTGCTCTGGTGAATTACATCTTCTTTAAAGGCAAATGGGAGAGA CCCTTTGAAGTCAAGGACACCGAGGAAGAGGACTTCCACGTGGACCAGGTGACCACCGTG AAGGTGCCTATGATGAAGCGTTTAGGCATGTTTAACATCCAGCACTGTAAGAAGCTGTCC AGCTGGGTGCTGCTGATGAAATACCTGGGCAATGCCACCGCCATCTTCTTCCTGCCTGAT GAGGGGAAACTACAGCACCTGGAAAATGAACTCACCCACGATATCATCACCAAGTTCCTG GAAAATGAAGACAGAAGGTCTGCCAGCTTACATTTACCCAAACTGTCCATTACTGGAACC TATGATCTGAAGAGCGTCCTGGGTCAACTGGGCATCACTAAGGTCTTCAGCAATGGGGCT GACCTCTCCGGGGTCACAGAGGAGGCACCCCTGAAGCTCTCCAAGGCCGTGCATAAGGCT GTGCTGACCATCGACGAGAAAGGGACTGAAGCTGCTGGGGCCATGTTTTTAGAGGCCATA CCCATGTCTATCCCCCCCGAGGTCAAGTTCAACAAACCCTTTGTCTTCTTAATGATTGAA CAAAATACCAAGTCTCCCCTCTTCATGGGAAAAGTGGTGAATCCCACCCAAAAATAA
- Chromosome Location
- 14
- Locus
- 14q32.1
- External Identifiers
Resource Link UniProtKB ID P01009 UniProtKB Entry Name A1AT_HUMAN GenBank Protein ID 177829 GenBank Gene ID K01396 GenAtlas ID SERPINA1 HGNC ID HGNC:8941 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01998 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol experimental unknown Details DB03345 Mercaptoethanol experimental unknown Details DB05481 Recombinant alpha 1-antitrypsin investigational unknown Details DB05961 PPL-100 investigational unknown Details DB09130 Copper approved, investigational unknown Details DB01593 Zinc approved, investigational unknown Details DB14007 Pentetic acid approved no substrate Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown ligand Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown ligand Details DB00080 Daptomycin approved, investigational no binder Details