Immunoglobulin J chain
Details
- Name
- Immunoglobulin J chain
- Synonyms
- IGCJ
- IGJ
- Joining chain of multimeric IgA and IgM
- Gene Name
- JCHAIN
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049876|Immunoglobulin J chain MKNHLLFWGVLAVFIKAVHVKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNI RIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSAT ETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD
- Number of residues
- 159
- Molecular Weight
- 18098.39
- Theoretical pI
- Not Available
- GO Classification
- Functionsantigen binding / IgA binding / immunoglobulin receptor binding / protein binding, bridging / protein homodimerization activityProcessesadaptive immune response / antibacterial humoral response / glomerular filtration / immune response / innate immune response / leukocyte migration / positive regulation of protein oligomerization / positive regulation of respiratory burst / receptor-mediated endocytosis / retina homeostasisComponentsblood microparticle / dimeric IgA immunoglobulin complex / extracellular exosome / extracellular region / extracellular space / monomeric IgA immunoglobulin complex / pentameric IgM immunoglobulin complex / secretory dimeric IgA immunoglobulin complex / secretory IgA immunoglobulin complex
- General Function
- Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
- Specific Function
- Antigen binding
- Pfam Domain Function
- Ig_J_chain (PF15097)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049877|Immunoglobulin J chain (JCHAIN) ATGAAGAACCATTTGCTTTTCTGGGGAGTCCTGGCGGTTTTTATTAAGGCTGTTCATGTG AAAGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCGGATT ACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATC CGAATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGA ACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGTGGAG CTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACA GAGACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATAT GGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGACTAA
- Chromosome Location
- 4
- Locus
- 4q13.3
- External Identifiers
Resource Link UniProtKB ID P01591 UniProtKB Entry Name IGJ_HUMAN HGNC ID HGNC:5713 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01593 Zinc approved, investigational unknown Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown component of Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown component of Details