Ig mu chain C region
Details
- Name
- Ig mu chain C region
- Synonyms
- Not Available
- Gene Name
- IGHM
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008862|Ig mu chain C region GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYKNNSDISSTRGFPSVL RGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPLPVIAELPPKVSVFVPPR DGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVTTDQVQAEAKESGPTTYKVTS TLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPSFASIFLTKST KLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGER FTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPAD VFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALP NRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY
- Number of residues
- 452
- Molecular Weight
- 49306.215
- Theoretical pI
- Not Available
- GO Classification
- Functionsantigen bindingProcessesadaptive immune response / antibacterial humoral response / B cell receptor signaling pathway / complement activation, classical pathway / defense response to Gram-negative bacterium / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / innate immune response / phagocytosis, engulfment / phagocytosis, recognition / positive regulation of B cell activation / receptor-mediated endocytosisComponentsblood microparticle / cell surface / external side of plasma membrane / extracellular exosome / extracellular space / hexameric IgM immunoglobulin complex / integral component of membrane / pentameric IgM immunoglobulin complex / plasma membrane
- General Function
- Antigen binding
- Specific Function
- IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
- Pfam Domain Function
- C1-set (PF07654)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P01871 UniProtKB Entry Name IGHM_HUMAN HGNC ID HGNC:5541 - General References
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- Watanabe S, Barnikol HU, Horn J, Bertram J, Hilschmann N: [The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule (author's transl)]. Hoppe Seylers Z Physiol Chem. 1973 Oct-Nov;354(10-11):1505-9. [Article]
- Mihaesco E, Barnikol-Watanabe S, Barnikol HU, Mihaesco C, Hilschmann N: The primary structure of the constant part of mu-chain-disease protein BOT. Eur J Biochem. 1980 Oct;111(1):275-86. [Article]
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- Rabbitts TH, Forster A, Milstein CP: Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences. Nucleic Acids Res. 1981 Sep 25;9(18):4509-24. [Article]
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