Phospholipase A2
Details
- Name
- Phospholipase A2
- Synonyms
- 3.1.1.4
- Group IB phospholipase A2
- Phosphatidylcholine 2-acylhydrolase 1B
- PLA2
- PLA2A
- PPLA2
- Gene Name
- PLA2G1B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019511|Phospholipase A2 MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC DRNAAICFSKAPYNKAHKNLDTKKYCQS
- Number of residues
- 148
- Molecular Weight
- 16359.535
- Theoretical pI
- 7.91
- GO Classification
- Functionsbile acid binding / calcium ion binding / calcium-dependent phospholipase A2 activity / phospholipase A2 activity / receptor bindingProcessesactin filament organization / activation of MAPK activity / activation of phospholipase A2 activity / antibacterial humoral response / arachidonic acid secretion / cellular response to insulin stimulus / defense response to Gram-positive bacterium / fatty acid biosynthetic process / glucose transport / glycerophospholipid biosynthetic process / innate immune response in mucosa / interleukin-8 production / intracellular signal transduction / leukotriene biosynthetic process / multicellular organismal lipid catabolic process / neutrophil chemotaxis / neutrophil mediated immunity / phosphatidic acid biosynthetic process / phosphatidylcholine acyl-chain remodeling / phosphatidylcholine metabolic process / phosphatidylethanolamine acyl-chain remodeling / phosphatidylglycerol acyl-chain remodeling / phosphatidylinositol acyl-chain remodeling / phosphatidylserine acyl-chain remodeling / phospholipid metabolic process / positive regulation of calcium ion transport into cytosol / positive regulation of DNA replication / positive regulation of fibroblast proliferation / positive regulation of immune response / positive regulation of NF-kappaB transcription factor activity / positive regulation of protein secretion / positive regulation of transcription from RNA polymerase II promoter / signal transduction / small molecule metabolic processComponentscell surface / extracellular region / extracellular space / secretory granule
- General Function
- Receptor binding
- Specific Function
- PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
- Pfam Domain Function
- Phospholip_A2_1 (PF00068)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0019512|Phospholipase A2 (PLA2G1B) ATGAAACTCCTTGTGCTAGCTGTGCTGCTCACAGTGGCCGCCGCCGACAGCGGCATCAGC CCTCGGGCCGTGTGGCAGTTCCGCAAAATGATCAAGTGCGTGATCCCGGGGAGTGACCCC TTCTTGGAATACAACAACTACGGCTGCTACTGTGGCTTGGGGGGCTCAGGCACCCCCGTG GATGAACTGGACAAGTGCTGCCAGACACATGACAACTGCTATGACCAGGCCAAGAAGCTG GACAGCTGTAAATTTCTGCTGGACAACCCGTACACCCACACCTATTCATACTCGTGCTCT GGCTCGGCAATCACCTGTAGCAGCAAAAACAAAGAGTGTGAGGCCTTCATTTGCAACTGC GACCGCAACGCTGCCATCTGCTTTTCAAAAGCTCCATATAACAAGGCACACAAGAACCTG GACACCAAGAAGTATTGTCAGAGTTGA
- Chromosome Location
- 12
- Locus
- 12q23-q24.1
- External Identifiers
Resource Link UniProtKB ID P04054 UniProtKB Entry Name PA21B_HUMAN GenBank Protein ID 190013 GenBank Gene ID M21054 HGNC ID HGNC:9030 - General References
- Seilhamer JJ, Randall TL, Yamanaka M, Johnson LK: Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA. 1986 Dec;5(6):519-27. [Article]
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- Verheij HM, Westerman J, Sternby B, De Haas GH: The complete primary structure of phospholipase A2 from human pancreas. Biochim Biophys Acta. 1983 Sep 14;747(1-2):93-9. [Article]
- Xu W, Yi L, Feng Y, Chen L, Liu J: Structural insight into the activation mechanism of human pancreatic prophospholipase A2. J Biol Chem. 2009 Jun 12;284(24):16659-66. doi: 10.1074/jbc.M808029200. Epub 2009 Mar 18. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02210 Hexane-1,6-Diol experimental unknown Details DB04552 Niflumic acid experimental yes inhibitor Details DB02795 P-Anisic Acid experimental unknown Details DB03565 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine experimental unknown Details DB03587 Pyruvaldehyde experimental unknown Details DB03633 Lpc-Ether experimental unknown Details DB02938 Heptanoic acid experimental, investigational unknown Details DB02659 Cholic Acid approved unknown Details DB07657 PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER experimental unknown Details DB07836 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL experimental unknown Details DB02448 N-Tridecanoic Acid experimental unknown Details DB00795 Sulfasalazine approved yes antagonist Details DB00972 Azelastine approved unknown inhibitor Details DB14009 Medical Cannabis experimental, investigational unknown inhibitorinducer Details DB00591 Fluocinolone acetonide approved, investigational, vet_approved unknown inhibitor Details