Heat shock protein beta-1

Details

Name
Heat shock protein beta-1
Synonyms
  • 28 kDa heat shock protein
  • Estrogen-regulated 24 kDa protein
  • Heat shock 27 kDa protein
  • HSP 27
  • HSP27
  • HSP28
  • HspB1
  • SRP27
  • Stress-responsive protein 27
Gene Name
HSPB1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006696|Heat shock protein beta-1
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPP
AAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEI
TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAK
Number of residues
205
Molecular Weight
22782.3
Theoretical pI
6.36
GO Classification
Functions
identical protein binding / poly(A) RNA binding / protein kinase binding / protein kinase C binding / protein kinase C inhibitor activity / ubiquitin binding
Processes
cellular response to vascular endothelial growth factor stimulus / gene expression / intracellular signal transduction / movement of cell or subcellular component / negative regulation of apoptotic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / negative regulation of protein kinase activity / platelet aggregation / positive regulation of angiogenesis / positive regulation of blood vessel endothelial cell migration / positive regulation of endothelial cell chemotaxis / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / positive regulation of interleukin-1 beta production / positive regulation of tumor necrosis factor biosynthetic process / regulation of I-kappaB kinase/NF-kappaB signaling / regulation of mRNA stability / regulation of translational initiation / response to unfolded protein / response to virus / retina homeostasis / vascular endothelial growth factor receptor signaling pathway
Components
cytoplasm / cytoskeleton / cytosol / extracellular exosome / extracellular space / focal adhesion / nucleus / plasma membrane / proteasome complex / spindle / Z disc
General Function
Ubiquitin binding
Specific Function
Involved in stress resistance and actin organization.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0020686|Heat shock protein beta-1 (HSPB1)
ATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGC
GACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGGGCTGCCCCGGCTGCCGGAG
GAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCC
GCCGCCATCGAGAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAA
CTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCGCTGGCGCGTGTCCCTGGAT
GTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATC
ACCGGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGG
AAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAG
GGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACC
ATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGAT
GAGACTGCCGCCAAGTAA
Chromosome Location
7
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP04792
UniProtKB Entry NameHSPB1_HUMAN
GenBank Gene IDL39370
GenAtlas IDHSPB1
HGNC IDHGNC:5246
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06094ApatorseninvestigationalunknownDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails