Meso-diaminopimelate D-dehydrogenase

Details

Name
Meso-diaminopimelate D-dehydrogenase
Synonyms
  • 1.4.1.16
  • DAPDH
Gene Name
ddh
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Amino acid sequence
>lcl|BSEQ0011128|Meso-diaminopimelate D-dehydrogenase
MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVADVDKHADDVD
VLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQVMNEAATAAGNVALVSTGWD
PGMFSINRVYAAAVLAEHQQHTFWGPGLSQGHSDALRRIPGVQKAVQYTLPSEDALEKAR
RGEAGDLTGKQTHKRQCFVVADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHT
GMPHGGHVITTGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVL
EVAPYLLSPENLDDLIARDV
Number of residues
320
Molecular Weight
35199.135
Theoretical pI
5.19
GO Classification
Functions
diaminopimelate dehydrogenase activity
Processes
diaminopimelate biosynthetic process / lysine biosynthetic process via diaminopimelate
General Function
Diaminopimelate dehydrogenase activity
Specific Function
Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate, since L,L-2,6-diaminopimelate, D,D-2,6-diaminopimelate, L-glutamate, L-alanine, L-leucine, L-valine, L-aspartate, L-threonine, L-homoserine, L-methionine, L-lysine, L-serine, L-phenylalanine, L-tyrosine, L-tryptophan, L-ornithine, L-histidine, L-arginine, D-glutamate, and D-alanine are not substrates for the oxidative deamination reaction. Can use NAD(+) only poorly since the activity observed in the presence of NAD(+) is about 3% of that with NADP(+).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011129|Meso-diaminopimelate D-dehydrogenase (ddh)
ATGACCAACATCCGCGTAGCTATCGTGGGCTACGGAAACCTGGGACGCAGCGTCGAAAAG
CTTATTGCCAAGCAGCCCGACATGGACCTTGTAGGAATCTTCTCGCGCCGGGCCACCCTC
GACACAAAGACGCCAGTCTTTGATGTCGCCGACGTGGACAAGCACGCCGACGACGTGGAC
GTGCTGTTCCTGTGCATGGGCTCCGCCACCGACATCCCTGAGCAGGCACCAAAGTTCGCG
CAGTTCGCCTGCACCGTAGACACCTACGACAACCACCGCGACATCCCACGCCACCGCCAG
GTCATGAACGAAGCCGCCACCGCAGCCGGCAACGTTGCACTGGTCTCTACCGGCTGGGAT
CCAGGAATGTTCTCCATCAACCGCGTCTACGCAGCGGCAGTCTTAGCCGAGCACCAGCAG
CACACCTTCTGGGGCCCAGGTTTGTCACAGGGCCACTCCGATGCTTTGCGACGCATCCCT
GGCGTTCAAAAGGCAGTCCAGTACACCCTCCCATCCGAAGACGCCCTGGAAAAGGCCCGC
CGCGGCGAAGCCGGCGACCTTACCGGAAAGCAAACCCACAAGCGCCAATGCTTCGTGGTT
GCCGACGCGGCCGATCACGAGCGCATCGAAAACGACATCCGCACCATGCCTGATTACTTC
GTTGGCTACGAAGTCGAAGTCAACTTCATCGACGAAGCAACCTTCGACTCCGAGCACACC
GGCATGCCACACGGTGGCCACGTGATTACCACCGGCGACACCGGTGGCTTCAACCACACC
GTGGAATACATCCTCAAGCTGGACCGAAACCCAGATTTCACCGCTTCCTCACAGATCGCT
TTCGGTCGCGCAGCTCACCGCATGAAGCAGCAGGGCCAAAGCGGAGCTTTCACCGTCCTC
GAAGTTGCTCCATACCTGCTCTCCCCAGAGAACTTGGACGATCTGATCGCACGCGACGTC
TAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP04964
UniProtKB Entry NameDAPDH_CORGL
GenBank Protein ID40493
GenBank Gene IDY00151
General References
  1. Ishino S, Mizukami T, Yamaguchi K, Katsumata R, Araki K: Nucleotide sequence of the meso-diaminopimelate D-dehydrogenase gene from Corynebacterium glutamicum. Nucleic Acids Res. 1987 May 11;15(9):3917. [Article]
  2. Ikeda M, Nakagawa S: The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol. 2003 Aug;62(2-3):99-109. Epub 2003 May 13. [Article]
  3. Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Kramer R, Linke B, McHardy AC, Meyer F, Mockel B, Pfefferle W, Puhler A, Rey DA, Ruckert C, Rupp O, Sahm H, Wendisch VF, Wiegrabe I, Tauch A: The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J Biotechnol. 2003 Sep 4;104(1-3):5-25. [Article]
  4. Reddy SG, Scapin G, Blanchard JS: Expression, purification, and crystallization of meso-diaminopimelate dehydrogenase from Corynebacterium glutamicum. Proteins. 1996 Aug;25(4):514-6. [Article]
  5. Scapin G, Reddy SG, Blanchard JS: Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum. Biochemistry. 1996 Oct 22;35(42):13540-51. [Article]
  6. Scapin G, Cirilli M, Reddy SG, Gao Y, Vederas JC, Blanchard JS: Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase. Biochemistry. 1998 Mar 10;37(10):3278-85. [Article]
  7. Cirilli M, Scapin G, Sutherland A, Vederas JC, Blanchard JS: The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate. Protein Sci. 2000 Oct;9(10):2034-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02892L-2-Amino-6-Methylene-Pimelic AcidexperimentalunknownDetails
DB035902,6-Diaminopimelic AcidexperimentalunknownDetails