Meso-diaminopimelate D-dehydrogenase
Details
- Name
- Meso-diaminopimelate D-dehydrogenase
- Synonyms
- 1.4.1.16
- DAPDH
- Gene Name
- ddh
- Organism
- Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
- Amino acid sequence
>lcl|BSEQ0011128|Meso-diaminopimelate D-dehydrogenase MTNIRVAIVGYGNLGRSVEKLIAKQPDMDLVGIFSRRATLDTKTPVFDVADVDKHADDVD VLFLCMGSATDIPEQAPKFAQFACTVDTYDNHRDIPRHRQVMNEAATAAGNVALVSTGWD PGMFSINRVYAAAVLAEHQQHTFWGPGLSQGHSDALRRIPGVQKAVQYTLPSEDALEKAR RGEAGDLTGKQTHKRQCFVVADAADHERIENDIRTMPDYFVGYEVEVNFIDEATFDSEHT GMPHGGHVITTGDTGGFNHTVEYILKLDRNPDFTASSQIAFGRAAHRMKQQGQSGAFTVL EVAPYLLSPENLDDLIARDV
- Number of residues
- 320
- Molecular Weight
- 35199.135
- Theoretical pI
- 5.19
- GO Classification
- Functionsdiaminopimelate dehydrogenase activityProcessesdiaminopimelate biosynthetic process / lysine biosynthetic process via diaminopimelate
- General Function
- Diaminopimelate dehydrogenase activity
- Specific Function
- Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate, since L,L-2,6-diaminopimelate, D,D-2,6-diaminopimelate, L-glutamate, L-alanine, L-leucine, L-valine, L-aspartate, L-threonine, L-homoserine, L-methionine, L-lysine, L-serine, L-phenylalanine, L-tyrosine, L-tryptophan, L-ornithine, L-histidine, L-arginine, D-glutamate, and D-alanine are not substrates for the oxidative deamination reaction. Can use NAD(+) only poorly since the activity observed in the presence of NAD(+) is about 3% of that with NADP(+).
- Pfam Domain Function
- DAPDH_C (PF16654)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011129|Meso-diaminopimelate D-dehydrogenase (ddh) ATGACCAACATCCGCGTAGCTATCGTGGGCTACGGAAACCTGGGACGCAGCGTCGAAAAG CTTATTGCCAAGCAGCCCGACATGGACCTTGTAGGAATCTTCTCGCGCCGGGCCACCCTC GACACAAAGACGCCAGTCTTTGATGTCGCCGACGTGGACAAGCACGCCGACGACGTGGAC GTGCTGTTCCTGTGCATGGGCTCCGCCACCGACATCCCTGAGCAGGCACCAAAGTTCGCG CAGTTCGCCTGCACCGTAGACACCTACGACAACCACCGCGACATCCCACGCCACCGCCAG GTCATGAACGAAGCCGCCACCGCAGCCGGCAACGTTGCACTGGTCTCTACCGGCTGGGAT CCAGGAATGTTCTCCATCAACCGCGTCTACGCAGCGGCAGTCTTAGCCGAGCACCAGCAG CACACCTTCTGGGGCCCAGGTTTGTCACAGGGCCACTCCGATGCTTTGCGACGCATCCCT GGCGTTCAAAAGGCAGTCCAGTACACCCTCCCATCCGAAGACGCCCTGGAAAAGGCCCGC CGCGGCGAAGCCGGCGACCTTACCGGAAAGCAAACCCACAAGCGCCAATGCTTCGTGGTT GCCGACGCGGCCGATCACGAGCGCATCGAAAACGACATCCGCACCATGCCTGATTACTTC GTTGGCTACGAAGTCGAAGTCAACTTCATCGACGAAGCAACCTTCGACTCCGAGCACACC GGCATGCCACACGGTGGCCACGTGATTACCACCGGCGACACCGGTGGCTTCAACCACACC GTGGAATACATCCTCAAGCTGGACCGAAACCCAGATTTCACCGCTTCCTCACAGATCGCT TTCGGTCGCGCAGCTCACCGCATGAAGCAGCAGGGCCAAAGCGGAGCTTTCACCGTCCTC GAAGTTGCTCCATACCTGCTCTCCCCAGAGAACTTGGACGATCTGATCGCACGCGACGTC TAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P04964 UniProtKB Entry Name DAPDH_CORGL GenBank Protein ID 40493 GenBank Gene ID Y00151 - General References
- Ishino S, Mizukami T, Yamaguchi K, Katsumata R, Araki K: Nucleotide sequence of the meso-diaminopimelate D-dehydrogenase gene from Corynebacterium glutamicum. Nucleic Acids Res. 1987 May 11;15(9):3917. [Article]
- Ikeda M, Nakagawa S: The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol. 2003 Aug;62(2-3):99-109. Epub 2003 May 13. [Article]
- Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Kramer R, Linke B, McHardy AC, Meyer F, Mockel B, Pfefferle W, Puhler A, Rey DA, Ruckert C, Rupp O, Sahm H, Wendisch VF, Wiegrabe I, Tauch A: The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J Biotechnol. 2003 Sep 4;104(1-3):5-25. [Article]
- Reddy SG, Scapin G, Blanchard JS: Expression, purification, and crystallization of meso-diaminopimelate dehydrogenase from Corynebacterium glutamicum. Proteins. 1996 Aug;25(4):514-6. [Article]
- Scapin G, Reddy SG, Blanchard JS: Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum. Biochemistry. 1996 Oct 22;35(42):13540-51. [Article]
- Scapin G, Cirilli M, Reddy SG, Gao Y, Vederas JC, Blanchard JS: Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase. Biochemistry. 1998 Mar 10;37(10):3278-85. [Article]
- Cirilli M, Scapin G, Sutherland A, Vederas JC, Blanchard JS: The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate. Protein Sci. 2000 Oct;9(10):2034-7. [Article]