Tetranectin
Details
- Name
- Tetranectin
- Synonyms
- C-type lectin domain family 3 member B
- Plasminogen kringle 4-binding protein
- TN
- TNA
- Gene Name
- CLEC3B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011525|Tetranectin MELWGAYLLLCLFSLLTQVTTEPPTQKPKKIVNAKKDVVNTKMFEELKSRLDTLAQEVAL LKEQQALQTVCLKGTKVHMKCFLAFTQTKTFHEASEDCISRGGTLGTPQTGSENDALYEY LRQSVGNEAEIWLGLNDMAAEGTWVDMTGARIAYKNWETEITAQPDGGKTENCAVLSGAA NGKWFDKRCRDQLPYICQFGIV
- Number of residues
- 202
- Molecular Weight
- 22536.665
- Theoretical pI
- 5.36
- GO Classification
- Functionscalcium ion binding / carbohydrate binding / heparin binding / kringle domain bindingProcessesbone mineralization / cellular response to organic substance / cellular response to transforming growth factor beta stimulus / ossification / positive regulation of plasminogen activation / skeletal system developmentComponentscytoplasm / extracellular exosome / extracellular region / extracellular space / granular component
- General Function
- Kringle domain binding
- Specific Function
- Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.
- Pfam Domain Function
- Lectin_C (PF00059)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0004125|609 bp ATGGAGCTCTGGGGGGCCTACCTCCTCCTCTGCCTCTTCTCCCTCCTGACCCAGGTCACC ACCGAGCCACCAACCCAGAAGCCCAAGAAGATTGTAAATGCCAAGAAAGATGTTGTGAAC ACAAAGATGTTTGAGGAGCTCAAGAGCCGTCTGGACACCCTGGCCCAGGAGGTGGCCCTG CTGAAGGAGCAGCAGGCCCTGCAGACGGTCTGCCTGAAGGGGACCAAGGTGCACATGAAA TGCTTTCTGGCCTTCACCCAGACGAAGACCTTCCACGAGGCCAGCGAGGACTGCATCTCG CGCGGGGGCACCCTGAGCACCCCTCAGACTGGCTCGGAGAACGACGCCCTGTATGAGTAC CTGCGCCAGAGCGTGGGCAACGAGGCCGAGATCTGGCTGGGCCTCAACGACATGGCGGCC GAGGGCACCTGGGTGGACATGACCGGCGCCCGCATCGCCTACAAGAACTGGGAGACTGAG ATCACCGCGCAACCCGATGGCGGCAAGACCGAGAACTGCGCGGTCCTGTCAGGCGCGGCC AACGGCAAGTGGTTCGACAAGCGCTGCCGCGATCAGCTGCCCTACATCTGCCAGTTCGGG ATCGTGTAG
- Chromosome Location
- Not Available
- Locus
- 3p22-p21.3
- External Identifiers
Resource Link UniProtKB ID P05452 UniProtKB Entry Name TETN_HUMAN GenBank Protein ID 37409 GenBank Gene ID X64559 GenAtlas ID CLEC3B HGNC ID HGNC:11891 - General References
- Wewer UM, Albrechtsen R: Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer. Lab Invest. 1992 Aug;67(2):253-62. [Article]
- Berglund L, Petersen TE: The gene structure of tetranectin, a plasminogen binding protein. FEBS Lett. 1992 Aug 31;309(1):15-9. [Article]
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- Fuhlendorff J, Clemmensen I, Magnusson S: Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein. Biochemistry. 1987 Oct 20;26(21):6757-64. [Article]
- Jaquinod M, Holtet TL, Etzerodt M, Clemmensen I, Thogersen HC, Roepstorff P: Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin. Biol Chem. 1999 Nov;380(11):1307-14. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Nielsen BB, Kastrup JS, Rasmussen H, Holtet TL, Graversen JH, Etzerodt M, Thogersen HC, Larsen IK: Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil. FEBS Lett. 1997 Jul 28;412(2):388-96. [Article]
- Kastrup JS, Nielsen BB, Rasmussen H, Holtet TL, Graversen JH, Etzerodt M, Thogersen HC, Larsen IK: Structure of the C-type lectin carbohydrate recognition domain of human tetranectin. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):757-66. [Article]