Colicin-Ia
Details
- Name
- Colicin-Ia
- Synonyms
- Not Available
- Gene Name
- cia
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0019533|Colicin-Ia MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEW VDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLR AGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREAR SLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLL GQQTRNDRAISEARNKLSSVTESLNTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRS STNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLSHSGLDYKRNILNDRNPVVTEDVE GDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSARNNLSARTNEQKHANDALNALLK EKENIRNQLSGINQKIAEEKRKQDELKATKDAINFTTEFLKSVSEKYGAKAEQLAREMAG QAKGKKIRNVEEALKTYEKYRADINKKINAKDRAAIAAALESVKLSDISSNLNRFSRGLG YAGKFTSLADWITEFGKAVRTENWRPLFVKTETIIAGNAATALVALVFSILTGSALGIIG YGLLMAVTGALIDESLVEKANKFWGI
- Number of residues
- 626
- Molecular Weight
- 69428.235
- Theoretical pI
- 9.72
- GO Classification
- Processescytolysis / defense response to Gram-negative bacteriumComponentsintegral component of membrane / plasma membrane
- General Function
- Not Available
- Specific Function
- This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
- Pfam Domain Function
- Transmembrane Regions
- 580-594 597-612
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0007937|1881 bp ATGTCTGACCCTGTACGTATTACAAATCCCGGTGCAGAATCGCTGGGGTATGATTCAGAT GGCCATGAAATTATGGCCGTTGATATTTATGTAAACCCTCCACGTGTCGATGTCTTTCAT GGTACCCCGCCTGCATGGAGTTCCTTCGGGAACAAAACCATCTGGGGCGGAAACGAGTGG GTTGATGATTCCCCAACCCGAAGTGATATCGAAAAAAGGGACAAGGAAATCACAGCGTAC AAAAACACGCTCAGCGCGCAGCAGAAAGAGAATGAGAATAAGCGTACTGAAGCCGGAAAA CGCCTCTCTGCGGCGATTGCTGCAAGGGAAAAAGATGAAAACACACTGAAAACACTCCGT GCCGGAAACGCAGATGCCGCTGATATTACACGACAGGAGTTCAGACTCCTGCAGGCAGAG CTGAGAGAATACGGATTCCGTACTGAAATCGCCGGATATGACGCCCTCCGGCTGCATACA GAGAGCCGGATGCTGTTTGCTGATGCTGATTCTCTTCGTATATCTCCCCGGGAGGCCAGG TCGTTAATCGAACAGGCTGAAAAACGGCAGAAGGATGCGCAGAACGCAGACAAGAAGGCC GCTGATATGCTTGCTGAATACGAGCGCAGAAAAGGTATTCTGGACACCCGGTTGTCAGAG CTGGAAAAAAATGGCGGGGCAGCCCTTGCCGTTCTTGATGCACAACAGGCCCGTCTGCTC GGGCAGCAGACACGGAATGACAGGGCCATTTCAGAGGCCCGGAATAAACTCAGTTCAGTG ACGGAATCGCTTAACACGGCCCGTAATGCATTAACCAGAGCTGAACAACAGCTGACGCAA CAGAAAAACACGCCTGACGGCAAAACGATAGTTTCCCCTGAAAAATTCCCGGGGCGTTCA TCAACAAATCATTCTATTGTTGTGAGCGGTGATCCGAGATTTGCCGGTACGATAAAAATC ACAACCAGCGCAGTCATCGATAACCGTGCAAACCTGAATTATCTTCTGAGCCATTCCGGT CTGGACTATAAACGCAATATTCTGAATGACCGGAATCCGGTGGTGACAGAGGATGTGGAA GGTGACAAGAAAATTTATAATGCTGAAGTTGCTGAATGGGATAAGTTACGGCAAAGATTG CTTGATGCCAGAAATAAAATCACCTCTGCTGAATCTGCGGTAAATTCGGCGAGAAATAAC CTCAGTGCCAGAACAAATGAGCAAAAGCATGCAAATGACGCTCTTAATGCCCTGTTGAAG GAAAAAGAGAATATACGTAACCAGCTTTCCGGCATCAATCAGAAGATAGCGGAAGAGAAA AGAAAACAGGATGAACTGAAGGCAACGAAAGACGCAATTAATTTCACAACAGAGTTCCTG AAATCAGTTTCAGAAAAATATGGTGCAAAAGCTGAGCAGTTAGCCAGAGAGATGGCCGGG CAGGCTAAAGGGAAGAAAATACGTAATGTTGAAGAGGCATTAAAAACGTATGAAAAGTAC CGGGCTGACATTAACAAAAAAATTAATGCAAAAGATCGTGCAGCGATTGCCGCAGCCCTT GAGTCTGTGAAGCTGTCTGATATATCGTCTAATCTGAACAGATTCAGTCGGGGACTGGGA TATGCAGGAAAATTTACAAGTCTTGCTGACTGGATCACTGAGTTTGGTAAGGCTGTCCGG ACAGAGAACTGGCGTCCTCTTTTTGTTAAAACAGAAACCATCATAGCAGGCAATGCCGCA ACGGCTCTTGTGGCACTGGTCTTCAGTATTCTTACCGGAAGCGCTTTAGGCATTATCGGG TATGGTTTACTGATGGCTGTCACCGGTGCGCTGATTGATGAATCGCTTGTGGAAAAAGCG AATAAGTTCTGGGGTATTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06716 UniProtKB Entry Name CEIA_ECOLX GenBank Protein ID 455438 GenBank Gene ID M13819 - General References
- Mankovich JA, Hsu CH, Konisky J: DNA and amino acid sequence analysis of structural and immunity genes of colicins Ia and Ib. J Bacteriol. 1986 Oct;168(1):228-36. [Article]
- Riley MA, Tan Y, Wang J: Nucleotide polymorphism in colicin E1 and Ia plasmids from natural isolates of Escherichia coli. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11276-80. [Article]
- Wiener M, Freymann D, Ghosh P, Stroud RM: Crystal structure of colicin Ia. Nature. 1997 Jan 30;385(6615):461-4. [Article]