Acyl-CoA-binding protein

Details

Name
Acyl-CoA-binding protein
Synonyms
  • ACBP
  • DBI
  • Diazepam-binding inhibitor
  • Endozepine
  • EP
Gene Name
DBI
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009397|Acyl-CoA-binding protein
MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWN
ELKGTSKEDAMKAYINKVEELKKKYGI
Number of residues
87
Molecular Weight
10044.37
Theoretical pI
Not Available
GO Classification
Functions
benzodiazepine receptor binding / lipid binding / long-chain fatty acyl-CoA binding / protein dimerization activity
Processes
behavioral fear response / hair follicle development / lateral ventricle development / learning or memory / long-term synaptic potentiation / phosphatidylcholine acyl-chain remodeling / transport / triglyceride metabolic process
Components
endoplasmic reticulum / extracellular exosome / Golgi apparatus / mitochondrion / perinuclear endoplasmic reticulum
General Function
Protein dimerization activity
Specific Function
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum
Gene sequence
>lcl|BSEQ0013132|Acyl-CoA-binding protein (DBI)
ATGTCTCAGGCTGAGTTTGAGAAAGCTGCAGAGGAGGTTAGGCACCTTAAGACCAAGCCA
TCGGATGAGGAGATGCTGTTCATCTATGGCCACTACAAACAAGCAACTGTGGGCGACATA
AATACAGAACGGCCCGGGATGTTGGACTTCACGGGCAAGGCCAAGTGGGATGCCTGGAAT
GAGCTGAAAGGGACTTCCAAGGAAGATGCCATGAAAGCTTACATCAACAAAGTAGAAGAG
CTAAAGAAAAAATACGGGATATGA
Chromosome Location
2
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP07108
UniProtKB Entry NameACBP_HUMAN
HGNC IDHGNC:2690
General References
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  2. Webb NR, Rose TM, Malik N, Marquardt H, Shoyab M, Todaro GJ, Lee DC: Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand. DNA. 1987 Feb;6(1):71-9. [Article]
  3. Nitz I, Doring F, Schrezenmeir J, Burwinkel B: Identification of new acyl-CoA binding protein transcripts in human and mouse. Int J Biochem Cell Biol. 2005 Nov;37(11):2395-405. [Article]
  4. Ludewig AH, Nitz I, Klapper M, Doring F: Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain. IUBMB Life. 2011 Jul;63(7):547-52. doi: 10.1002/iub.471. [Article]
  5. Nitz I, Kruse ML, Klapper M, Doring F: Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms. J Cell Mol Med. 2011 Apr;15(4):909-27. doi: 10.1111/j.1582-4934.2010.01055.x. [Article]
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  8. Marquardt H, Todaro GJ, Shoyab M: Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor. J Biol Chem. 1986 Jul 25;261(21):9727-31. [Article]
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  12. Hansen JS, Faergeman NJ, Kragelund BB, Knudsen J: Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells. Biochem J. 2008 Mar 15;410(3):463-72. [Article]
  13. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
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  21. Taskinen JP, van Aalten DM, Knudsen J, Wierenga RK: High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. Proteins. 2007 Jan 1;66(1):229-38. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails
DB03381HexadecanalexperimentalunknownDetails