Trypsin-1
Details
- Name
- Trypsin-1
- Synonyms
- 3.4.21.4
- Beta-trypsin
- Cationic trypsinogen
- Serine protease 1
- TRP1
- TRY1
- TRYP1
- Trypsin I
- Gene Name
- PRSS1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016543|Trypsin-1 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK NTIAANS
- Number of residues
- 247
- Molecular Weight
- 26557.88
- Theoretical pI
- 6.48
- GO Classification
- Functionsmetal ion binding / serine-type endopeptidase activityProcessescobalamin metabolic process / digestion / extracellular matrix disassembly / extracellular matrix organization / proteolysis / small molecule metabolic process / vitamin metabolic process / water-soluble vitamin metabolic processComponentsblood microparticle / extracellular exosome / extracellular region / extracellular space
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
- Pfam Domain Function
- Trypsin (PF00089)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016544|Trypsin-1 (PRSS1) ATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCTTGCTGCCCCCTTTGATGAT GATGACAAGATCGTTGGGGGCTACAACTGTGAGGAGAATTCTGTCCCCTACCAGGTGTCC CTGAATTCTGGCTACCACTTCTGTGGTGGCTCCCTCATCAACGAACAGTGGGTGGTATCA GCAGGCCACTGCTACAAGTCCCGCATCCAGGTGAGACTGGGAGAGCACAACATCGAAGTC CTGGAGGGGAATGAGCAGTTCATCAATGCAGCCAAGATCATCCGCCACCCCCAATACGAC AGGAAGACTCTGAACAATGACATCATGTTAATCAAGCTCTCCTCACGTGCAGTAATCAAC GCCCGCGTGTCCACCATCTCTCTGCCCACCGCCCCTCCAGCCACTGGCACGAAGTGCCTC ATCTCTGGCTGGGGCAACACTGCGAGCTCTGGCGCCGACTACCCAGACGAGCTGCAGTGC CTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACC AGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCT GGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGT GCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAG AACACCATAGCTGCCAATAGCTAA
- Chromosome Location
- 7
- Locus
- 7q32-qter|7q34
- External Identifiers
Resource Link UniProtKB ID P07477 UniProtKB Entry Name TRY1_HUMAN GenBank Protein ID 521216 GenBank Gene ID M22612 GenAtlas ID PRSS1 HGNC ID HGNC:9475 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01665 2H-Benzimidazol-2-amine experimental unknown Details DB01705 Bis(5-Amidino-Benzimidazolyl)Methane experimental unknown Details DB01725 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide experimental unknown Details DB01741 CRA_17693 experimental unknown Details DB01745 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester experimental unknown Details DB01805 Monoisopropylphosphorylserine experimental unknown Details DB01836 [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone experimental unknown Details DB01876 Bis(5-Amidino-2-Benzimidazolyl)Methanone experimental unknown Details DB02045 Amylamine experimental unknown Details DB02063 CRA_16847 experimental unknown Details DB02081 Bis-Benzamidine experimental unknown Details DB02084 CRA_17312 experimental unknown Details DB02112 Zk-806450 experimental unknown Details DB02269 [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium experimental unknown Details DB02354 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine experimental unknown Details DB02366 CRA_10762 experimental unknown Details DB02435 Aminomethylcyclohexane experimental unknown Details DB02464 Benzylamine experimental unknown Details DB02665 (1R,2S)-2-Phenylcyclopropanaminium experimental unknown Details DB02744 RPR131247 experimental unknown Details DB02812 RWJ-56423 experimental unknown inhibitor Details DB02989 CRA_10972 experimental unknown Details DB03016 CRA_1801 experimental unknown Details DB03081 [N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidine experimental unknown Details DB03127 Benzamidine experimental unknown Details DB03213 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone experimental unknown Details DB03243 4-Fluorobenzylamine experimental unknown Details DB03373 ZK-806711 experimental unknown Details DB03417 (2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acid experimental unknown Details DB03443 bis(5-amidino-benzimidazolyl)methanone zinc experimental unknown Details DB03555 CRA_11092 experimental unknown Details DB04008 Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium experimental unknown Details DB04107 [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester experimental unknown Details DB04125 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine experimental unknown Details DB04238 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid experimental unknown Details DB04246 CRA_23653 experimental unknown Details DB04269 Cyclotheonamide A experimental unknown Details DB04301 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate experimental unknown Details DB04311 4-Phenylbutylamine experimental unknown Details DB04325 Phenethylamine experimental unknown Details DB04391 Aeruginosin 98-B experimental unknown Details DB04410 3-Phenylpropylamine experimental unknown Details DB04424 RPR128515 experimental unknown Details DB04442 Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminium experimental unknown Details DB04563 CRA_9678 experimental unknown Details DB03976 Phosphorylisopropane experimental unknown Details DB04654 4-PIPERIDIN-4-YLBUTANAL experimental unknown Details DB06692 Aprotinin approved, investigational, withdrawn unknown Details DB06840 diethyl [(1R)-1,5-diaminopentyl]boronate experimental unknown Details DB06845 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide experimental unknown Details DB06850 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide experimental unknown Details DB02287 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine experimental unknown Details DB01905 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine experimental unknown Details DB02463 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine experimental unknown Details DB06853 N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide experimental unknown Details DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine experimental unknown Details DB06858 N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide experimental unknown Details DB06918 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE experimental unknown Details DB06923 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE experimental unknown Details DB02288 CRA-9334 experimental unknown Details DB07088 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide experimental unknown Details DB07091 (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide experimental unknown Details DB07095 (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide experimental unknown Details DB07131 (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide experimental unknown Details DB04432 ZK-805623 experimental unknown Details DB02526 CRA_10655 experimental unknown Details DB04470 CRA_10656 experimental unknown Details DB03159 CRA_8696 experimental unknown Details DB07229 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE experimental unknown Details DB03595 CRA_9785 experimental unknown Details DB02875 CRA_1802 experimental unknown Details DB04215 CRA_9076 experimental unknown Details DB06855 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine experimental unknown Details DB01771 CRA_10991 experimental unknown Details DB01939 5-Amidino-Benzimidazole experimental unknown Details DB07368 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE experimental unknown Details DB01737 Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester experimental unknown Details DB01767 Hemi-Babim experimental unknown Details DB03608 Diminazene experimental unknown Details DB07491 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid experimental unknown Details DB03173 CRA_10433 experimental unknown Details DB03643 CRA_1144 experimental unknown Details DB03136 4-Iodobenzo[B]Thiophene-2-Carboxamidine experimental unknown Details DB03876 Thieno[2,3-B]Pyridine-2-Carboxamidine experimental unknown Details DB04446 Benzo[B]Thiophene-2-Carboxamidine experimental unknown Details DB04336 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea experimental unknown Details DB03337 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea experimental unknown Details DB07985 +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE experimental unknown Details DB08184 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE experimental unknown Details DB08254 2-Naphthalenesulfonic acid experimental unknown Details DB08420 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID experimental unknown Details DB03251 RWJ-51084 experimental unknown Details DB04790 2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitol experimental unknown Details DB04791 2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL experimental unknown Details DB04792 2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL experimental unknown Details DB04793 1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitol experimental unknown Details DB03374 3,5-Diiodotyrosine experimental unknown Details DB08763 [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE experimental unknown Details DB12831 Gabexate investigational no inhibitor Details DB12598 Nafamostat investigational yes inhibitor Details DB13729 Camostat experimental unknown inhibitor Details