Cathepsin L1
Details
- Name
- Cathepsin L1
- Synonyms
- 3.4.22.15
- Cathepsin L
- CTSL1
- Major excreted protein
- MEP
- Gene Name
- CTSL
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011547|Cathepsin L1 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
- Number of residues
- 333
- Molecular Weight
- 37563.97
- Theoretical pI
- 5.14
- GO Classification
- Functionscollagen binding / cysteine-type endopeptidase activity / cysteine-type peptidase activity / fibronectin binding / histone binding / proteoglycan binding / serpin family protein bindingProcessesadaptive immune response / antigen processing and presentation / antigen processing and presentation of exogenous peptide antigen via MHC class II / cellular response to thyroid hormone stimulus / collagen catabolic process / extracellular matrix disassembly / extracellular matrix organization / innate immune response / macrophage apoptotic process / proteolysis / proteolysis involved in cellular protein catabolic process / toll-like receptor signaling pathwayComponentsendolysosome lumen / extracellular exosome / extracellular region / extracellular space / lysosomal lumen / lysosome / nucleus
- General Function
- Serpin family protein binding
- Specific Function
- Important for the overall degradation of proteins in lysosomes.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Lysosome
- Gene sequence
>lcl|BSEQ0011548|Cathepsin L1 (CTSL) ATGAATCCTACACTCATCCTTGCTGCCTTTTGCCTGGGAATTGCCTCAGCTACTCTAACA TTTGATCACAGTTTAGAGGCACAGTGGACCAAGTGGAAGGCGATGCACAACAGATTATAC GGCATGAATGAAGAAGGATGGAGGAGAGCAGTGTGGGAGAAGAACATGAAGATGATTGAA CTGCACAATCAGGAATACAGGGAAGGGAAACACAGCTTCACAATGGCCATGAACGCCTTT GGAGACATGACCAGTGAAGAATTCAGGCAGGTGATGAATGGCTTTCAAAACCGTAAGCCC AGGAAGGGGAAAGTGTTCCAGGAACCTCTGTTTTATGAGGCCCCCAGATCTGTGGATTGG AGAGAGAAAGGCTACGTGACTCCTGTGAAGAATCAGGGTCAGTGTGGTTCTTGTTGGGCT TTTAGTGCTACTGGTGCTCTTGAAGGACAGATGTTCCGGAAAACTGGGAGGCTTATCTCA CTGAGTGAGCAGAATCTGGTAGACTGCTCTGGGCCTCAAGGCAATGAAGGCTGCAATGGT GGCCTAATGGATTATGCTTTCCAGTATGTTCAGGATAATGGAGGCCTGGACTCTGAGGAA TCCTATCCATATGAGGCAACAGAAGAATCCTGTAAGTACAATCCCAAGTATTCTGTTGCT AATGACACCGGCTTTGTGGACATCCCTAAGCAGGAGAAGGCCCTGATGAAGGCAGTTGCA ACTGTGGGGCCCATTTCTGTTGCTATTGATGCAGGTCATGAGTCCTTCCTGTTCTATAAA GAAGGCATTTATTTTGAGCCAGACTGTAGCAGTGAAGACATGGATCATGGTGTGCTGGTG GTTGGCTACGGATTTGAAAGCACAGAATCAGATAACAATAAATATTGGCTGGTGAAGAAC AGCTGGGGTGAAGAATGGGGCATGGGTGGCTACGTAAAGATGGCCAAAGACCGGAGAAAC CATTGTGGAATTGCCTCAGCAGCCAGCTACCCCACTGTGTGA
- Chromosome Location
- 9
- Locus
- 9q21-q22
- External Identifiers
Resource Link UniProtKB ID P07711 UniProtKB Entry Name CATL1_HUMAN GenBank Protein ID 29715 GenBank Gene ID X12451 GenAtlas ID CTSL HGNC ID HGNC:2537 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03661 L-cysteic acid experimental unknown Details DB07477 Felbinac experimental unknown Details DB12010 Fostamatinib approved, investigational unknown inhibitor Details DB14962 Trastuzumab deruxtecan approved, investigational unknown substrate Details