Chymotrypsin-like elastase family member 2A

Details

Name
Chymotrypsin-like elastase family member 2A
Synonyms
  • 3.4.21.71
  • ELA2A
  • Elastase-2A
Gene Name
CELA2A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012615|Chymotrypsin-like elastase family member 2A
MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGG
SLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGN
DIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLV
VDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSR
LGCNYYHKPSVFTRVSNYIDWINSVIANN
Number of residues
269
Molecular Weight
28887.5
Theoretical pI
8.54
GO Classification
Functions
serine hydrolase activity / serine-type endopeptidase activity
Processes
proteolysis
Components
extracellular space / keratohyalin granule
General Function
Serine-type endopeptidase activity
Specific Function
Acts upon elastin.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0012616|Chymotrypsin-like elastase family member 2A (CELA2A)
ATGATAAGGACGCTGCTGCTGTCCACTTTGGTGGCTGGAGCCCTCAGTTGTGGGGACCCC
ACTTACCCACCTTATGTGACTAGGGTGGTTGGCGGTGAAGAAGCGAGGCCCAACAGCTGG
CCCTGGCAGGTCTCCCTGCAGTACAGCTCCAATGGCAAGTGGTACCACACCTGCGGAGGG
TCCCTGATAGCCAACAGCTGGGTCCTGACGGCTGCCCACTGCATCAGCTCCTCCAGGACC
TACCGCGTGGGGCTGGGCCGGCACAACCTCTACGTTGCGGAGTCCGGCTCGCTGGCAGTC
AGTGTCTCTAAGATTGTGGTGCACAAGGACTGGAACTCCAACCAAATCTCCAAAGGGAAC
GACATTGCCCTGCTCAAACTGGCTAACCCCGTCTCCCTCACCGACAAGATCCAGCTGGCC
TGCCTCCCTCCTGCCGGCACCATTCTACCCAACAACTACCCCTGCTACGTCACGGGCTGG
GGAAGGCTGCAGACCAACGGGGCTGTTCCTGATGTCCTGCAGCAGGGCCGGTTGCTGGTT
GTGGACTATGCCACCTGCTCCAGCTCTGCCTGGTGGGGCAGCAGCGTGAAAACCAGTATG
ATCTGTGCTGGGGGTGATGGCGTGATCTCCAGCTGCAACGGAGACTCTGGCGGGCCACTG
AACTGTCAGGCGTCTGACGGCCGGTGGCAGGTGCACGGCATCGTCAGCTTCGGGTCTCGC
CTCGGCTGCAACTACTACCACAAGCCCTCCGTCTTCACGCGGGTCTCCAATTACATCGAC
TGGATCAATTCGGTGATTGCAAATAACTAA
Chromosome Location
1
Locus
1p36.21
External Identifiers
ResourceLink
UniProtKB IDP08217
UniProtKB Entry NameCEL2A_HUMAN
GenBank Protein ID182023
GenBank Gene IDM16631
HGNC IDHGNC:24609
General References
  1. Fletcher TS, Shen WF, Largman C: Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry. 1987 Nov 17;26(23):7256-61. [Article]
  2. Kawashima I, Tani T, Shimoda K, Takiguchi Y: Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA. 1987 Apr;6(2):163-72. [Article]
  3. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.: Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J Biochem. 1987 Dec;102(6):1555-63. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  7. Moulard M, Michon T, Kerfelec B, Chapus C: Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. FEBS Lett. 1990 Feb 12;261(1):179-83. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB069012-(2-HYDROXY-CYCLOPENTYL)-PENT-4-ENALexperimentalunknownDetails