Arsenical pump-driving ATPase
Details
- Name
- Arsenical pump-driving ATPase
- Synonyms
- 3.6.3.16
- Arsenical resistance ATPase
- Arsenite-translocating ATPase
- Arsenite-transporting ATPase
- Gene Name
- arsA
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0011351|Arsenical pump-driving ATPase MQFLQNIPPYLFFTGKGGVGKTSISCATAIRLAEQGKRVLLVSTDPASNVGQVFSQTIGI TIQAIASVPGLSALEIDPQAAAQQYRARIVDPIKGVLPDDVVSSINEQLSGACTTEIAAF DEFTGLLTDASLLTRFDHIIFDTAPTGHTIRLLQLPGAWSSFIDSNPEGASCLGPMAGLE KQREQYAYAVEALSDPKRTRLVLVARLQKSTLQEVARTHLELAAIGLKNQYLVINGVLPK TEAANDTLAAAIWEREQEALANLPADLAGLPTDTLFLQPVNMVGVSALSRLLSTQPVASP SSDEYLQQRPDIPSLSALVDDIARNEHGLIMLMGKGGVGKTTMAAAIAVRLADMGFDVHL TTSDPAAHLSMTLNGSLNNLQVSRIDPHEETERYRQHVLETKGKELDEAGKRLLEEDLRS PCTEEIAVFQAFSRVIREAGKRFVVMDTAPTGHTLLLLDATGAYHREIAKKMGEKGHFTT PMMLLQDPERTKVLLVTLPETTPVLEAANLQADLERAGIHPWGWIINNSLSIADTRSPLL RMRAQQELPQIESVKRQHASRVALVPVLASEPTGIDKLKQLAG
- Number of residues
- 583
- Molecular Weight
- 63187.75
- Theoretical pI
- 5.64
- GO Classification
- Functionsarsenite-transmembrane transporting ATPase activity / ATP bindingProcessesdetoxification of arsenic-containing substance
- General Function
- Atp binding
- Specific Function
- Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents.
- Pfam Domain Function
- ArsA_ATPase (PF02374)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003734|1752 bp ATGCAATTCTTACAGAATATCCCCCCTTATCTGTTTTTTACGGGTAAAGGAGGCGTGGGT AAAACCTCTATTTCCTGCGCCACGGCGATCCGTCTGGCAGAACAGGGGAAACGGGTGCTG CTGGTCAGTACCGATCCGGCCTCAAACGTAGGCCAGGTGTTTAGCCAGACGATTGGCATT ACCATTCAGGCAATAGCCTCTGTTCCTGGATTGTCGGCTCTTGAGATTGATCCTCAGGCT GCTGCACAACAGTACCGGGCCAGAATCGTTGACCCTATTAAAGGCGTCCTGCCTGATGAC GTTGTTTCCAGCATCAACGAACAACTGTCAGGTGCATGCACAACAGAGATTGCGGCTTTT GATGAATTTACCGGATTACTGACAGATGCCTCTCTGCTGACGCGGTTTGACCATATCATT TTTGATACCGCGCCGACGGGTCACACCATTCGCCTTCTGCAGTTGCCGGGCGCCTGGAGT AGCTTTATTGACAGCAATCCCGAGGGCGCGTCCTGTCTCGGCCCAATGGCGGGGCTGGAA AAGCAGCGTGAACAGTATGCCTATGCTGTTGAAGCGTTGTCTGATCCAAAGCGTACCCGA CTGGTATTAGTTGCTCGTCTGCAAAAATCCACGTTGCAGGAAGTCGCCCGGACTCATCTG GAACTTGCCGCCATCGGCCTTAAAAATCAGTACCTGGTTATTAATGGCGTTCTGCCCAAA ACTGAAGCGGCAAACGATACACTGGCTGCTGCAATATGGGAGCGTGAACAGGAGGCGCTG GCCAATCTTCCCGCTGATCTTGCAGGTTTGCCAACTGACACATTATTTCTCCAGCCGGTC AATATGGTCGGTGTGTCTGCGCTCAGCAGGCTTCTCTCCACTCAGCCTGTAGCGTCGCCA TCCTCGGATGAATACCTGCAACAGCGGCCTGATATTCCGTCACTTTCTGCGTTGGTTGAT GATATTGCCCGTAATGAACATGGCCTGATTATGCTGATGGGTAAAGGTGGCGTGGGGAAA ACCACGATGGCTGCTGCCATTGCTGTCAGGCTGGCCGACATGGGATTTGATGTCCATCTG ACAACATCTGATCCTGCGGCGCATCTCAGCATGACCCTGAACGGTAGCCTTAACAACCTG CAGGTCAGCAGGATCGATCCTCACGAGGAAACGGAACGCTATCGTCAGCATGTTCTTGAA ACAAAGGGAAAAGAACTGGACGAAGCGGGAAAACGCCTGCTGGAAGAGGACTTACGCTCA CCTTGCACTGAGGAAATTGCTGTTTTCCAGGCCTTTTCACGGGTGATTCGTGAAGCGGGT AAACGTTTCGTGGTGATGGATACGGCTCCGACCGGACACACGCTGTTGCTGCTGGATGCT ACAGGCGCGTACCACCGCGAAATTGCGAAGAAAATGGGAGAAAAAGGCCATTTCACCACA CCGATGATGCTGCTTCAGGATCCGGAGCGCACTAAAGTGTTACTGGTCACGCTGCCGGAA ACCACGCCCGTGCTTGAAGCGGCAAATTTACAGGCCGACCTTGAGCGTGCAGGCATTCAC CCCTGGGGCTGGATTATCAATAACAGCCTTTCCATTGCGGATACCCGTTCGCCACTGCTT CGTATGCGGGCACAACAGGAACTTCCGCAGATAGAGAGCGTTAAACGCCAGCACGCCAGC CGTGTCGCTCTTGTTCCCGTACTGGCGTCAGAACCAACCGGCATCGACAAACTCAAACAA CTTGCTGGGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08690 UniProtKB Entry Name ARSA1_ECOLX GenBank Protein ID 151857 GenBank Gene ID J02591 - General References
- Chen CM, Misra TK, Silver S, Rosen BP: Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon. J Biol Chem. 1986 Nov 15;261(32):15030-8. [Article]
- Rosen BP: The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase. Res Microbiol. 1990 Mar-Apr;141(3):336-41. [Article]