Arsenate reductase

Details

Name
Arsenate reductase
Synonyms
  • 1.20.4.1
  • Arsenical pump modifier
Gene Name
arsC
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0010920|Arsenate reductase
MSNITIYHNPACGTSRNTLEMIRNSGTEPTIILYLENPPSRDELVKLIADMGISVRALLR
KNVEPYEQLGLAEDKFTDDQLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLDILQDAQ
KGAFTKEDGEKVVDEAGKRLK
Number of residues
141
Molecular Weight
15830.1
Theoretical pI
4.99
GO Classification
Functions
arsenate reductase (glutaredoxin) activity
Processes
response to arsenic-containing substance
General Function
Arsenate reductase (glutaredoxin) activity
Specific Function
Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0002623|426 bp
ATGAGCAACATCACTATTTATCATAACCCAGCCTGCGGCACCTCGCGTAATACGCTGGAG
ATGATCCGCAACAGCGGTACCGAGCCGACCATTATTCTTTACCTTGAAAACCCGCCTTCG
AGGGATGAGCTGGTTAAACTTATTGCCGATATGGGTATTTCAGTACGAGCGCTGCTGCGT
AAAAACGTTGAACCTTACGAGCAACTGGGTCTTGCAGAAGATAAATTTACTGACGATCAG
CTCATCGACTTTATGTTGCAACACCCAATTCTGATTAACCGTCCGATCGTGGTTACGCCG
CTGGGAACCAGACTGTGCCGTCCTTCTGAAGTGGTTCTGGATATCCTACAGGATGCGCAG
AAAGGGGCTTTCACTAAGGAAGACGGTGAAAAAGTCGTTGATGAAGCAGGAAAACGGCTG
AAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP08692
UniProtKB Entry NameARSC1_ECOLX
GenBank Protein ID151859
GenBank Gene IDJ02591
General References
  1. Chen CM, Misra TK, Silver S, Rosen BP: Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon. J Biol Chem. 1986 Nov 15;261(32):15030-8. [Article]
  2. Rosen BP, Weigel U, Monticello RA, Edwards BP: Molecular analysis of an anion pump: purification of the ArsC protein. Arch Biochem Biophys. 1991 Feb 1;284(2):381-5. [Article]
  3. Rosen BP: The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase. Res Microbiol. 1990 Mar-Apr;141(3):336-41. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01808Thiarsahydroxy-CysteineexperimentalunknownDetails
DB03289Thiarsa Dihydroxy CysteineexperimentalunknownDetails
DB03352S-ArsonocysteineexperimentalunknownDetails
DB04456Arsenous acidexperimental, investigationalunknownDetails