HTH-type transcriptional regulator QacR
Details
- Name
- HTH-type transcriptional regulator QacR
- Synonyms
- Not Available
- Gene Name
- qacR
- Organism
- Staphylococcus haemolyticus
- Amino acid sequence
>lcl|BSEQ0010884|HTH-type transcriptional regulator QacR MNLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLFLEILNIEESK WQEQWKKEQIKCKTNREKFYLYNELSLTTEYYYPLQNAIIEFYTEYYKTNSINEKMNKLE NKYIDAYHVIFKEGNLNGEWCINDVNAVSKIAANAVNGIVTFTHEQNINERIKLMNKFSQ IFLNGLSK
- Number of residues
- 188
- Molecular Weight
- 22174.175
- Theoretical pI
- 8.55
- GO Classification
- FunctionsDNA binding / transcription factor activity, sequence-specific DNA bindingProcessesnegative regulation of transcription, DNA-templated / transcription, DNA-templated
- General Function
- Transcription factor activity, sequence-specific dna binding
- Specific Function
- Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0002522|567 bp TTATTTACTAAGTCCATTTAAAAAAATTTGAGAGAACTTGTTCATAAGTTTAATTCTTTC ATTAATATTTTGTTCATGTGTAAAGGTAACAATTCCATTAACAGCGTTTGCTGCTATTTT ACTAACAGCATTAACATCATTAATACACCATTCGCCATTTAAATTACCCTCCTTAAAAAT TACATGATAAGCATCTATATATTTGTTTTCTAATTTATTCATTTTTTCATTAATGCTATT AGTTTTATAATATTCAGTGTAAAATTCAATTATTGCGTTTTGAAGTGGATAATAGTATTC GGTTGTTAAAGATAGTTCATTATATAAATAAAATTTTTCTCTATTAGTTTTACATTTGAT TTGTTCCTTTTTCCACTGTTCTTGCCATTTAGATTCTTCTATATTTAAAATTTCTAAAAA TAGATTTTCTTTTGTTTTAAAGTGATAATAAAGATTCCCTTTACTACTTTCTGATAATTT AACAATTTCTCCAGTAGTAGTGGCATTATATCCATTTTTTATAAATAATTCCTTTGCGAC ACCTAGTATTTTATCTTTCAAGTTCAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A0N5 UniProtKB Entry Name QACR_STAHA GenBank Protein ID 8574416 GenBank Gene ID AJ400722 - General References
- Anthonisen IL, Sunde M, Steinum TM, Sidhu MS, Sorum H: Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug- resistant Staphylococcus haemolyticus strains of animal and human origins. Antimicrob Agents Chemother. 2002 Nov;46(11):3606-12. [Article]