Glutamate--cysteine ligase

Details

Name
Glutamate--cysteine ligase
Synonyms
  • 6.3.2.2
  • Gamma-ECS
  • Gamma-glutamylcysteine synthetase
  • GCS
  • gsh-I
Gene Name
gshA
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0016539|Glutamate--cysteine ligase
MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTD
FAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPCYIAEGQDIELAQYG
TSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGDISGADAKEKISAGY
FRVIRNYYRFGWVIPYLFGASPAICSSFLQGKPTSLPFEKTECGMYYLPYATSLRLSDLG
YTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELY
APIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALA
DAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTL
DSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPL
EILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA
Number of residues
518
Molecular Weight
58268.695
Theoretical pI
5.04
GO Classification
Functions
ATP binding / glutamate-cysteine ligase activity / metal ion binding
Processes
cellular response to arsenic-containing substance / cellular response to mercury ion / glutathione biosynthetic process / hyperosmotic response
Components
cytosol
General Function
Metal ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016540|Glutamate--cysteine ligase (gshA)
TTGATCCCGGACGTATCACAGGCGCTGGCCTGGCTGGAAAAACATCCTCAGGCGTTAAAG
GGGATACAGCGTGGGCTGGAGCGCGAAACTTTGCGTGTTAATGCTGATGGCACACTGGCA
ACAACAGGTCATCCTGAAGCATTAGGTTCCGCACTGACGCACAAATGGATTACTACCGAT
TTTGCGGAAGCATTGCTGGAATTCATTACACCAGTGGATGGTGATATTGAACATATGCTG
ACCTTTATGCGCGATCTGCATCGTTATACGGCGCGCAATATGGGCGATGAGCGGATGTGG
CCGTTAAGTATGCCATGCTACATCGCAGAAGGTCAGGACATCGAACTGGCACAGTACGGC
ACTTCTAACACCGGACGCTTTAAAACGCTGTATCGTGAAGGGCTGAAAAATCGCTACGGC
GCGCTGATGCAAACCATTTCCGGCGTGCACTACAATTTCTCTTTGCCAATGGCATTCTGG
CAAGCGAAGTGCGGTGATATCTCGGGCGCTGATGCCAAAGAGAAAATTTCTGCGGGCTAT
TTCCGCGTTATCCGCAATTACTATCGTTTCGGTTGGGTCATTCCTTATCTGTTTGGTGCA
TCTCCGGCGATTTGTTCTTCTTTCCTGCAAGGAAAACCAACGTCGCTGCCGTTTGAGAAA
ACCGAGTGCGGTATGTATTACCTGCCGTATGCGACCTCTCTTCGTTTGAGCGATCTCGGC
TATACCAATAAATCGCAAAGCAATCTTGGTATTACCTTCAACGATCTTTACGAGTACGTA
GCGGGCCTTAAACAGGCAATCAAAACGCCATCGGAAGAGTACGCGAAGATTGGTATTGAG
AAAGACGGTAAGAGGCTGCAAATCAACAGCAACGTGTTGCAGATTGAAAACGAACTGTAC
GCGCCGATTCGTCCAAAACGCGTTACCCGCAGCGGCGAGTCGCCTTCTGATGCGCTGTTA
CGTGGCGGCATTGAATATATTGAAGTGCGTTCGCTGGACATCAACCCGTTCTCGCCGATT
GGTGTAGATGAACAGCAGGTGCGATTCCTCGACCTGTTTATGGTCTGGTGTGCGCTGGCT
GATGCACCGGAAATGAGCAGTAGCGAACTTGCCTGTACACGCGTTAACTGGAACCGGGTG
ATCCTCGAAGGTCGCAAACCGGGTCTGACGCTGGGTATCGGCTGCGAAACCGCACAGTTC
CCGTTACCGCAGGTGGGTAAAGATCTGTTCCGCGATCTGAAACGCGTCGCGCAAACGCTG
GATAGTATTAACGGCGGCGAAGCGTATCAGAAAGTGTGTGATGAACTGGTTGCCTGCTTC
GATAATCCCGATCTGACTTTCTCTGCCCGTATCTTAAGGTCTATGATTGATACTGGTATT
GGCGGAACAGGCAAAGCATTTGCAGAAGCCTACCGTAATCTGCTGCGTGAAGAGCCGCTG
GAAATTCTGCGCGAAGAGGATTTTGTAGCCGAGCGCGAGGCGTCTGAACGCCGTCAGCAG
GAAATGGAAGCCGCTGATACCGAACCGTTTGCGGTGTGGCTGGAAAAACACGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A6W9
UniProtKB Entry NameGSH1_ECOLI
GenBank Protein ID581100
GenBank Gene IDX03954
General References
  1. Watanabe K, Yamano Y, Murata K, Kimura A: The nucleotide sequence of the gene for gamma-glutamylcysteine synthetase of Escherichia coli. Nucleic Acids Res. 1986 Jun 11;14(11):4393-400. [Article]
  2. Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. [Article]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  4. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04464N-FormylmethionineexperimentalunknownDetails