Glutamate--cysteine ligase
Details
- Name
- Glutamate--cysteine ligase
- Synonyms
- 6.3.2.2
- Gamma-ECS
- Gamma-glutamylcysteine synthetase
- GCS
- gsh-I
- Gene Name
- gshA
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0016539|Glutamate--cysteine ligase MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTD FAEALLEFITPVDGDIEHMLTFMRDLHRYTARNMGDERMWPLSMPCYIAEGQDIELAQYG TSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGDISGADAKEKISAGY FRVIRNYYRFGWVIPYLFGASPAICSSFLQGKPTSLPFEKTECGMYYLPYATSLRLSDLG YTNKSQSNLGITFNDLYEYVAGLKQAIKTPSEEYAKIGIEKDGKRLQINSNVLQIENELY APIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCALA DAPEMSSSELACTRVNWNRVILEGRKPGLTLGIGCETAQFPLPQVGKDLFRDLKRVAQTL DSINGGEAYQKVCDELVACFDNPDLTFSARILRSMIDTGIGGTGKAFAEAYRNLLREEPL EILREEDFVAEREASERRQQEMEAADTEPFAVWLEKHA
- Number of residues
- 518
- Molecular Weight
- 58268.695
- Theoretical pI
- 5.04
- GO Classification
- FunctionsATP binding / glutamate-cysteine ligase activity / metal ion bindingProcessescellular response to arsenic-containing substance / cellular response to mercury ion / glutathione biosynthetic process / hyperosmotic responseComponentscytosol
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Pfam Domain Function
- Glu_cys_ligase (PF04262)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016540|Glutamate--cysteine ligase (gshA) TTGATCCCGGACGTATCACAGGCGCTGGCCTGGCTGGAAAAACATCCTCAGGCGTTAAAG GGGATACAGCGTGGGCTGGAGCGCGAAACTTTGCGTGTTAATGCTGATGGCACACTGGCA ACAACAGGTCATCCTGAAGCATTAGGTTCCGCACTGACGCACAAATGGATTACTACCGAT TTTGCGGAAGCATTGCTGGAATTCATTACACCAGTGGATGGTGATATTGAACATATGCTG ACCTTTATGCGCGATCTGCATCGTTATACGGCGCGCAATATGGGCGATGAGCGGATGTGG CCGTTAAGTATGCCATGCTACATCGCAGAAGGTCAGGACATCGAACTGGCACAGTACGGC ACTTCTAACACCGGACGCTTTAAAACGCTGTATCGTGAAGGGCTGAAAAATCGCTACGGC GCGCTGATGCAAACCATTTCCGGCGTGCACTACAATTTCTCTTTGCCAATGGCATTCTGG CAAGCGAAGTGCGGTGATATCTCGGGCGCTGATGCCAAAGAGAAAATTTCTGCGGGCTAT TTCCGCGTTATCCGCAATTACTATCGTTTCGGTTGGGTCATTCCTTATCTGTTTGGTGCA TCTCCGGCGATTTGTTCTTCTTTCCTGCAAGGAAAACCAACGTCGCTGCCGTTTGAGAAA ACCGAGTGCGGTATGTATTACCTGCCGTATGCGACCTCTCTTCGTTTGAGCGATCTCGGC TATACCAATAAATCGCAAAGCAATCTTGGTATTACCTTCAACGATCTTTACGAGTACGTA GCGGGCCTTAAACAGGCAATCAAAACGCCATCGGAAGAGTACGCGAAGATTGGTATTGAG AAAGACGGTAAGAGGCTGCAAATCAACAGCAACGTGTTGCAGATTGAAAACGAACTGTAC GCGCCGATTCGTCCAAAACGCGTTACCCGCAGCGGCGAGTCGCCTTCTGATGCGCTGTTA CGTGGCGGCATTGAATATATTGAAGTGCGTTCGCTGGACATCAACCCGTTCTCGCCGATT GGTGTAGATGAACAGCAGGTGCGATTCCTCGACCTGTTTATGGTCTGGTGTGCGCTGGCT GATGCACCGGAAATGAGCAGTAGCGAACTTGCCTGTACACGCGTTAACTGGAACCGGGTG ATCCTCGAAGGTCGCAAACCGGGTCTGACGCTGGGTATCGGCTGCGAAACCGCACAGTTC CCGTTACCGCAGGTGGGTAAAGATCTGTTCCGCGATCTGAAACGCGTCGCGCAAACGCTG GATAGTATTAACGGCGGCGAAGCGTATCAGAAAGTGTGTGATGAACTGGTTGCCTGCTTC GATAATCCCGATCTGACTTTCTCTGCCCGTATCTTAAGGTCTATGATTGATACTGGTATT GGCGGAACAGGCAAAGCATTTGCAGAAGCCTACCGTAATCTGCTGCGTGAAGAGCCGCTG GAAATTCTGCGCGAAGAGGATTTTGTAGCCGAGCGCGAGGCGTCTGAACGCCGTCAGCAG GAAATGGAAGCCGCTGATACCGAACCGTTTGCGGTGTGGCTGGAAAAACACGCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A6W9 UniProtKB Entry Name GSH1_ECOLI GenBank Protein ID 581100 GenBank Gene ID X03954 - General References
- Watanabe K, Yamano Y, Murata K, Kimura A: The nucleotide sequence of the gene for gamma-glutamylcysteine synthetase of Escherichia coli. Nucleic Acids Res. 1986 Jun 11;14(11):4393-400. [Article]
- Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]