33 kDa chaperonin
Details
- Name
- 33 kDa chaperonin
- Synonyms
- Heat shock protein 33
- HSP33
- yrfI
- Gene Name
- hslO
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0006216|33 kDa chaperonin MPQHDQLHRYLFENFAVRGELVTVSETLQQILENHDYPQPVKNVLAELLVATSLLTATLK FDGDITVQLQGDGPMNLAVINGNNNQQMRGVARVQGEIPENADLKTLVGNGYVVITITPS EGERYQGVVGLEGDTLAACLEDYFMRSEQLPTRLFIRTGDVDGKPAAGGMLLQVMPAQNA QQDDFDHLATLTETIKTEELLTLPANEVLWRLYHEEEVTVYDPQDVEFKCTCSRERCADA LKTLPDEEVDSILAEDGEIDMHCDYCGNHYLFNAMDIAEIRNNASPADPQVH
- Number of residues
- 292
- Molecular Weight
- 32534.245
- Theoretical pI
- 4.1
- GO Classification
- Functionsidentical protein bindingProcessesprotein folding / response to heatComponentscytosol
- General Function
- Identical protein binding
- Specific Function
- Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
- Pfam Domain Function
- HSP33 (PF01430)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017017|33 kDa chaperonin (hslO) ATGCCGCAACATGACCAATTACATCGCTATCTGTTTGAAAACTTTGCCGTGCGCGGCGAA CTGGTAACCGTTTCGGAAACCCTGCAACAGATCCTTGAGAACCACGATTATCCGCAGCCC GTTAAAAACGTGCTGGCAGAACTGCTGGTTGCGACCAGCCTGTTAACCGCTACGCTGAAG TTTGATGGTGATATCACCGTACAGCTGCAGGGCGACGGTCCGATGAATCTGGCGGTTATT AACGGTAACAATAACCAGCAGATGCGCGGTGTGGCGCGCGTGCAGGGCGAAATTCCAGAA AATGCCGACCTGAAAACGCTGGTCGGCAATGGTTACGTGGTGATCACCATTACCCCGAGC GAAGGCGAACGCTATCAGGGCGTAGTTGGTCTGGAAGGTGATACCCTGGCGGCCTGCCTG GAAGATTACTTTATGCGTTCTGAACAGCTGCCGACGCGCCTGTTTATTCGCACCGGCGAC GTAGACGGCAAACCGGCTGCAGGCGGTATGTTGTTGCAGGTAATGCCTGCGCAAAATGCC CAGCAGGACGACTTTGACCACCTGGCGACGCTAACCGAAACCATCAAAACCGAAGAACTG CTGACCTTACCGGCAAACGAAGTGTTGTGGCGTTTGTATCACGAAGAAGAGGTGACGGTT TACGATCCGCAGGATGTGGAGTTCAAATGCACCTGCTCGCGTGAACGTTGCGCCGATGCG CTGAAAACGCTGCCTGATGAAGAAGTTGATAGCATCCTGGCGGAAGATGGCGAAATTGAC ATGCATTGTGATTACTGCGGTAACCACTATCTGTTCAATGCGATGGATATTGCTGAAATC CGCAACAACGCGTCTCCGGCAGATCCGCAAGTTCATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A6Y5 UniProtKB Entry Name HSLO_ECOLI GenBank Gene ID AP009048 - General References
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Jakob U, Muse W, Eser M, Bardwell JC: Chaperone activity with a redox switch. Cell. 1999 Feb 5;96(3):341-52. [Article]
- Barbirz S, Jakob U, Glocker MO: Mass spectrometry unravels disulfide bond formation as the mechanism that activates a molecular chaperone. J Biol Chem. 2000 Jun 23;275(25):18759-66. [Article]