Cytochrome P450 2A1
Details
- Name
- Cytochrome P450 2A1
- Synonyms
- 1.14.14.1
- Cyp2a-1
- CYPIIA1
- Cytochrome P450-UT-F
- Steroid hormones 7-alpha-hydroxylase
- Testosterone 7-alpha-hydroxylase
- Gene Name
- Cyp2a1
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0021410|Cytochrome P450 2A1 MLDTGLLLVVILASLSVMLLVSLWQQKIRGRLPPGPTPLPFIGNYLQLNTKDVYSSITQL SERYGPVFTIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGEQATYNTLFKGYGVAFSSG ERAKQLRRLSIATLRDFGVGKRGVEERILEEAGYLIKMLQGTCGAPIDPTIYLSKTVSNV ISSIVFGERFDYEDTEFLSLLQMMGQMNRFAASPTGQLYDMFHSVMKYLPGPQQQIIKVT QKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQEEKNGNSEFHMKNLVMTTLSLFFAG SETVSSTLRYGFLLLMKHPDVEAKVHEEIEQVIGRNRQPQYEDHMKMPYTQAVINEIQRF SNLAPLGIPRRIIKNTTFRGFFLPKGTDVFPILGSLMTDPKFFPSPKDFDPQNFLDDKGQ LKKNAAFLPFSTGKRFCLGDGLAKMELFLLLTTILQNFRFKFPMKLEDINESPKPLGFTR IIPKYTMSFMPI
- Number of residues
- 492
- Molecular Weight
- 55994.635
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessescoumarin metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Highly active in the 7-alpha-hydroxylation of testosterone, progesterone and androstenedione.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0021411|Cytochrome P450 2A1 (Cyp2a1) ATGCTGGACACAGGACTGCTTCTGGTGGTCATATTGGCCTCCCTGAGCGTCATGCTCTTG GTGTCCCTCTGGCAGCAGAAAATCAGGGGGAGATTGCCTCCAGGACCCACTCCTTTGCCT TTCATTGGAAATTATCTGCAGCTGAATACAAAAGACGTATACAGTTCCATCACACAGCTC AGTGAGCGCTATGGTCCTGTGTTCACCATCCACCTTGGGCCTCGCCGGGTTGTGGTGCTT TATGGATACGATGCAGTCAAAGAGGCTTTGGTGGACCAAGCTGAGGAGTTCAGTGGACGA GGCGAACAGGCTACCTACAATACACTCTTCAAAGGCTATGGCGTGGCATTCAGCAGTGGG GAGCGGGCAAAACAACTCAGGCGCCTCTCTATAGCCACATTGAGAGATTTTGGTGTGGGC AAGCGTGGTGTAGAGGAGCGTATCCTGGAGGAGGCAGGCTATTTGATCAAGATGTTGCAG GGCACTTGTGGAGCCCCCATTGACCCCACCATCTACCTGAGCAAAACAGTCTCCAATGTT ATTAGCTCCATTGTCTTCGGGGAACGCTTCGACTATGAGGACACGGAGTTCCTGTCACTG CTGCAGATGATGGGTCAAATGAACAGATTTGCAGCTTCACCCACAGGGCAGCTCTATGAC ATGTTCCATTCAGTGATGAAGTACCTGCCTGGACCACAGCAACAGATCATCAAGGTTACT CAGAAACTGGAAGACTTCATGATAGAGAAAGTGAGGCAGAACCATAGTACCCTGGACCCC AATTCCCCAAGGAACTTCATTGACTCCTTTCTCATCCGCATGCAAGAGGAGAAAAATGGC AATTCAGAGTTCCACATGAAGAACCTAGTGATGACAACACTAAGCCTCTTCTTTGCTGGG TCTGAGACAGTCAGCTCCACACTACGCTACGGCTTCCTTCTACTCATGAAGCATCCAGAT GTGGAGGCCAAGGTCCATGAGGAAATTGAGCAGGTGATCGGCAGGAACCGACAGCCTCAG TATGAGGACCACATGAAGATGCCCTACACCCAGGCTGTGATCAATGAGATCCAAAGATTT TCTAACTTGGCTCCCTTGGGCATTCCTCGAAGGATTATCAAGAACACAACCTTCCGTGGC TTCTTCCTCCCCAAGGCCACCGATGTGTTCCCTATATTAGGTTCTCTGATGACAGACCCA AAGTTCTTCCCTAGCCCCAAAGACTTCGACCCCCAGAACTTCCTGGATGACAAGGGACAG TTGAAGAAAAATGCTGCTTTCCTCCCTTTCTCCACTGGGAAGCGATTCTGCTTGGGAGAT GGCCTGGCTAAGATGGAGCTCTTCCTGCTGCTCACCACTATTTTACAGAACTTCCGTTTC AAGTTCCCAATGAAACTAGAAGACATCAACGAGTCCCCCAAACCCTTGGGGTTTACCAGG ATCATACCAAAGTACACCATGAGCTTCATGCCCATCTGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P11711 UniProtKB Entry Name CP2A1_RAT - General References
- Nagata K, Matsunaga T, Gillette J, Gelboin HV, Gonzalez FJ: Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. J Biol Chem. 1987 Feb 25;262(6):2787-93. [Article]
- Matsunaga T, Nomoto M, Kozak CA, Gonzalez FJ: Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7. Biochemistry. 1990 Feb 6;29(5):1329-41. [Article]
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- Arlotto MP, Greenway DJ, Parkinson A: Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7 alpha-hydroxylase activity. Arch Biochem Biophys. 1989 May 1;270(2):441-57. [Article]
- Imaoka S, Kamataki T, Funae Y: Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats. J Biochem. 1987 Oct;102(4):843-51. [Article]
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