Penicillin acylase
Details
- Name
- Penicillin acylase
- Synonyms
- 3.5.1.11
- Penicillin V amidase
- PVA
- Gene Name
- Not Available
- Organism
- Lysinibacillus sphaericus
- Amino acid sequence
>lcl|BSEQ0016380|Penicillin acylase MLGCSSLSIRTTDDKSLFARTMDFTMEPDSKVIIVPRNYGIRLLEKENVVINNSYAFVGM GSTDITSPVLYDGVNEKGLMGAMLYYATFATYADEPKKGTTGINPVYVISQVLGNCVTVD DVIEKLTSYTLLNEANIILGFAPPLHYTFTDASGESIVIEPDKTGITIHRKTIGVMTNSP GYEWHQTNLRAYIGVTPNPPQDIMMGDLDLTPFGQGAGGLGLPGDFTPSARFLRVAYWKK YTEKAKNETEGVTNLFHILSSVNIPKGVVLTNEGKTDYTIYTSAMCAQSKNYYFKLYDNS RISAVSLMAENLNSQDLITFEWDRKQDIKQLNQVNVMS
- Number of residues
- 338
- Molecular Weight
- 37457.375
- Theoretical pI
- 5.02
- GO Classification
- Functionspenicillin amidase activityProcessesresponse to antibiotic
- General Function
- Penicillin amidase activity
- Specific Function
- The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
- Pfam Domain Function
- CBAH (PF02275)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002590|1017 bp ATGTTAGGTTGCAGTAGCTTATCAATTCGTACAACAGATGATAAAAGTTTATTCGCTCGC ACAATGGATTTTACAATGGAACCAGATAGTAAAGTGATTATTGTCCCACGTAATTACGGC ATTCGATTGTTAGAAAAAGAAAATGTAGTCATTAACAATTCATATGCTTTTGTTGGAATG GGAAGCACTGACATTACATCACCAGTTCTCTATGATGGGGTAAACGAAAAGGGATTAATG GGCGCAATGCTTTACTATGCTACATTTGCGACTTATGCTGACGAACCTAAAAAAGGCACA ACAGGCATCAATCCCGTGTATGTAATTTCTCAAGTTTTAGGAAATTGTGTAACTGTCGAT GATGTTATTGAAAAATTAACTTCTTATACATTATTGAATGAGGCCAATATAATACTTGGC TTTGCACCCCCACTTCACTATACATTTACAGATGCTTCTGGTGAATCGATTGTTATTGAA CCGGATAAAACAGGCATTACCATTCATCGAAAAACGATTGGCGTCATGACGAATAGCCCT GGCTATGAATGGCATCAGACAAATTTAAGAGCTTACATTGGTGTCACACCAAATCCGCCA CAAGATATAATGATGGGAGACTTGGATTTGACACCGTTTGGGCAAGGGGCAGGGGGCTTA GGATTACCAGGTGATTTTACGCCGTCAGCACGTTTTCTTCGGGTAGCATACTGGAAAAAA TATACTGAAAAAGCCAAAAATGAAACAGAAGGCGTAACAAACTTGTTCCATATTCTATCT TCTGTAAATATCCCAAAAGGTGTTGTTTTGACAAATGAGGGGAAAACGGATTATACCATC TATACCTCAGCTATGTGTGCACAAAGTAAAAACTATTACTTTAAACTGTATGACAATAGT CGAATTTCAGCCGTTTCCTTAATGGCTGAAAATTTAAATAGTCAAGATTTAATTACATTT GAGTGGGATCGTAAACAAGATATTAAGCAATTAAATCAAGTAAATGTAATGAGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12256 UniProtKB Entry Name PAC_LYSSH GenBank Protein ID 143306 GenBank Gene ID M15660 - General References
- Olsson A, Uhlen M: Sequencing and heterologous expression of the gene encoding penicillin V amidase from Bacillus sphaericus. Gene. 1986;45(2):175-81. [Article]
- Suresh CG, Pundle AV, SivaRaman H, Rao KN, Brannigan JA, McVey CE, Verma CS, Dauter Z, Dodson EJ, Dodson GG: Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members. Nat Struct Biol. 1999 May;6(5):414-6. [Article]