Bone marrow proteoglycan

Details

Name
Bone marrow proteoglycan
Synonyms
  • BMPG
  • MBP
  • Proteoglycan 2
Gene Name
PRG2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037161|Bone marrow proteoglycan
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEW
GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQ
AWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRW
NFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
Number of residues
222
Molecular Weight
25205.345
Theoretical pI
6.64
GO Classification
Functions
carbohydrate binding / heparin binding
Processes
defense response to bacterium / defense response to nematode / immune response / negative regulation of interleukin-10 production / positive regulation of interleukin-4 production / regulation of cytokine biosynthetic process
Components
extracellular exosome / extracellular region / transport vesicle
General Function
Heparin binding
Specific Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0019238|Bone marrow proteoglycan (PRG2)
ATGAAACTCCCCTTACTTCTGGCTCTTCTATTTGGGGCAGTTTCTGCTCTTCATCTAAGG
TCTGAGACTTCCACCTTTGAGACCCCTTTGGGTGCTAAGACGCTGCCTGAGGATGAGGAG
ACACCAGAGCAGGAGATGGAGGAGACCCCTTGCAGGGAGCTGGAGGAAGAGGAGGAGTGG
GGCTCTGGAAGTGAAGATGCCTCCAAGAAAGATGGGGCTGTTGAGTCTATCTCAGTGCCA
GATATGGTGGACAAAAACCTTACGTGTCCTGAGGAAGAGGACACAGTAAAAGTGGTGGGC
ATCCCTGGGTGCCAGACCTGCCGCTACCTCCTGTTTACTTGCCGGAGGTGCTACAGGGGC
AACCTGGTTTCCATCCACAACTTCAATATTAATTATCGAATCCAGTGTTCTGTCAGCGCG
CTCAACCAGGGTCAAGTCTGGATTGGAGGCAGGATCACAGGCTCGGGTCGCTGCAGACGC
TTTCAGTGGGTTGACGGCAGCCGCTGGAACTTTGCGTACTGGGCTGCTCACCAGCCCTGG
TCCCGCGGTGGTCACTGCGTGGCCCTGTGTACCCGAGGAGGCCACTGGCGTCGAGCCCAC
TGCCTCAGAAGACTTCCTTTCATCTGTTCCTACTGA
Chromosome Location
11
Locus
11q12
External Identifiers
ResourceLink
UniProtKB IDP13727
UniProtKB Entry NamePRG2_HUMAN
GenBank Protein ID34476
GenBank Gene IDY00809
GenAtlas IDPRG2
HGNC IDHGNC:9362
General References
  1. Barker RL, Gleich GJ, Pease LR: Acidic precursor revealed in human eosinophil granule major basic protein cDNA. J Exp Med. 1988 Oct 1;168(4):1493-8. [Article]
  2. Barker RL, Loegering DA, Arakawa KC, Pease LR, Gleich GJ: Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. Gene. 1990 Feb 14;86(2):285-9. [Article]
  3. McGrogan M, Simonsen C, Scott R, Griffith J, Ellis N, Kennedy J, Campanelli D, Nathan C, Gabay J: Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein. J Exp Med. 1988 Dec 1;168(6):2295-308. [Article]
  4. Yoshimatsu K, Ohya Y, Shikata Y, Seto T, Hasegawa Y, Tanaka I, Kawamura T, Kitoh K, Toyoshima S, Osawa T: Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. Mol Immunol. 1992 Apr;29(4):537-46. [Article]
  5. Li MS, Sun L, Satoh T, Fisher LM, Spry CJ: Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. Biochem J. 1995 Feb 1;305 ( Pt 3):921-7. [Article]
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  9. Shikata Y, Hayashi Y, Yoshimatsu K, Ohya Y, Seto T, Fukushima K, Yoshida Y: Pro-major basic protein has three types of sugar chains at the pro-portion. Biochim Biophys Acta. 1993 Jun 4;1163(3):243-9. [Article]
  10. Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L: Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem. 1993 Jun 15;268(17):12243-6. [Article]
  11. Oxvig C, Haaning J, Kristensen L, Wagner JM, Rubin I, Stigbrand T, Gleich GJ, Sottrup-Jensen L: Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. J Biol Chem. 1995 Jun 9;270(23):13645-51. [Article]
  12. Wasmoen TL, Bell MP, Loegering DA, Gleich GJ, Prendergast FG, McKean DJ: Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein. J Biol Chem. 1988 Sep 5;263(25):12559-63. [Article]
  13. Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF: Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5610-4. [Article]
  14. Weller PF, Ackerman SJ, Smith JA: Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase. J Leukoc Biol. 1988 Jan;43(1):1-4. [Article]
  15. Kristensen T, Oxvig C, Sand O, Moller NP, Sottrup-Jensen L: Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA. Biochemistry. 1994 Feb 15;33(6):1592-8. [Article]
  16. Wasmoen TL, McKean DJ, Benirschke K, Coulam CB, Gleich GJ: Evidence of eosinophil granule major basic protein in human placenta. J Exp Med. 1989 Dec 1;170(6):2051-63. [Article]
  17. Oxvig C, Haaning J, Hojrup P, Sottrup-Jensen L: Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum. Biochem Mol Biol Int. 1994 May;33(2):329-36. [Article]
  18. Oxvig C, Gleich GJ, Sottrup-Jensen L: Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein. FEBS Lett. 1994 Mar 21;341(2-3):213-7. [Article]
  19. Bonno M, Oxvig C, Kephart GM, Wagner JM, Kristensen T, Sottrup-Jensen L, Gleich GJ: Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. Lab Invest. 1994 Oct;71(4):560-6. [Article]
  20. Overgaard MT, Oxvig C, Christiansen M, Lawrence JB, Conover CA, Gleich GJ, Sottrup-Jensen L, Haaning J: Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. Biol Reprod. 1999 Oct;61(4):1083-9. [Article]
  21. Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C: Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem. 2000 Oct 6;275(40):31128-33. [Article]
  22. Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C: Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. J Biol Chem. 2003 Jan 24;278(4):2106-17. Epub 2002 Nov 5. [Article]
  23. Ulrich M, Petre A, Youhnovski N, Promm F, Schirle M, Schumm M, Pero RS, Doyle A, Checkel J, Kita H, Thiyagarajan N, Acharya KR, Schmid-Grendelmeier P, Simon HU, Schwarz H, Tsutsui M, Shimokawa H, Bellon G, Lee JJ, Przybylski M, Doring G: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. J Biol Chem. 2008 Oct 17;283(42):28629-40. doi: 10.1074/jbc.M801196200. Epub 2008 Aug 11. [Article]
  24. Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR: Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity. J Biol Chem. 2001 Jul 13;276(28):26197-203. Epub 2001 Apr 23. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00020Sargramostimapproved, investigationalunknownDetails
DB06752Chymopapainapproved, withdrawnyesdegradationDetails