Fusion glycoprotein F0
Details
- Name
- Fusion glycoprotein F0
- Synonyms
- Fusion glycoprotein F0 precursor
- Gene Name
- F
- Organism
- Human respiratory syncytial virus B (strain 18537)
- Amino acid sequence
>lcl|BSEQ0010478|Fusion glycoprotein F0 MELLIHRSSAIFLTLAVNALYLTSSQNITEEFYQSTCSAVSRGYFSALRTGWYTSVITIE LSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAANNRARREAPQYMNYTIN TTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKNALLSTNKAVVS LSNGVSVLTSKVLDLKNYINNRLLPIVNQQSCRISNIETVIEFQQMNSRLLEITREFSVN AGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYV VQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRGWYCDNAGSVSFFPQADTCKV QSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSKTDISSSVITSLGAIVSCYGKT KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKNLYVKGEPIINYYDP LVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVNTGKSTTNIMITTIIIVIIVVLLS LIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK
- Number of residues
- 574
- Molecular Weight
- 63687.815
- Theoretical pI
- 9.14
- GO Classification
- Processesfusion of virus membrane with host plasma membrane / positive regulation of syncytium formation by virusComponentshost cell plasma membrane / integral component of membrane / viral envelope / virion membrane
- General Function
- Not Available
- Specific Function
- During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
- Pfam Domain Function
- Fusion_gly (PF00523)
- Transmembrane Regions
- 530-550
- Cellular Location
- Virion membrane
- Gene sequence
>lcl|BSEQ0001367|1725 bp ATGGAGTTGCTGATCCACAGGTCAAGTGCAATCTTCCTAACTCTTGCTGTTAATGCATTG TACCTCACCTCAAGTCAGAACATAACTGAGGAGTTTTACCAATCGACATGTAGTGCAGTT AGCAGAGGTTATTTTAGTGCTTTAAGAACAGGTTGGTATACCAGTGTCATAACAATAGAA TTAAGTAATATAAAAGAAACCAAATGCAATGGAACTGACACTAAAGTAAAACTTATAAAA CAAGAATTAGATAAGTATAAGAATGCAGTAACAGAATTACAGCTACTTATGCAAAACACG CCAGCTGCCAACAACCGGGCCAGAAGAGAAGCACCACAGTACATGAACTACACAATCAAT ACCACAAAAAACCTAAATGTATCAATAAGCAAGAAAAGGAAACGAAGATTTCTGGGCTTC TTGTTAGGTGTAGGATCTGCAATAGCAAGTGGTATAGCTGTATCCAAAGTTTTACACCTT GAAGGAGAAGTGAACAAAATCAAAAATGCTTTGTTGTCTACAAACAAAGCTGTAGTCAGT CTATCAAATGGGGTCAGTGTTTTAACCAGCAAAGTGTTAGATCTCAAGAATTACATAAAT AACCGATTATTACCCATAGTAAATCAACAGAGCTGTCGCATCTCCAACATTGAAACAGTT ATAGAATTCCAGCAGATGAATAGCAGATTGTTGGAAATCACCAGAGAATTTAGTGTTAAT GCAGGTGTAACAACACCTTTAAGCACTTACATGTTAACAAACAGTGAGTTACTATCATTG ATCAATGATATGCCTATAACAAATGACCAGAAAAAATTAATGTCAAGCAATGTTCAGATA GTAAGGCAACAAAGTTATTCTATCATGTCTATAATAAAGGAAGAAGTCCTTGCATATGTT GTACAGCTACCTATCTATGGTGTAATAGATACACCTTGCTGGAAATTACACACATCACCT CTATGCACCACCAACATCAAAGAAGGATCAAATATTTGTTTAACAAGGACTGATAGAGGA TGGTATTGTGATAATGCAGGATCAGTATCCTTCTTCCCACAGGCTGATACTTGCAAAGTA CAGTCCAATCGAGTATTTTGTGACACTATGAACAGTTTAACATTACCAAGTGAAGTCAGC CTTTGTAACACTGACATATTCAATTCCAAGTATGACTGCAAAATTATGACATCAAAAACA GACATAAGCAGCTCAGTAATTACTTCTCTTGGAGCTATAGTGTCATGCTATGGAAAAACT AAATGCACTGCATCCAATAAAAATCGTGGGATTATAAAGACATTTTCTAATGGTTGTGAC TATGTGTCAAACAAAGGAGTAGATACTGTGTCAGTGGGCAACACTTTATACTATGTAAAC AAGCTGGAAGGCAAAAACCTTTATGTAAAAGGGGAACCTATAATAAATTACTATGATCCT CTAGTGTTTCCTTCTGATGAGTTTGATGCATCAATATCTCAAGTCAATGAAAAAATCAAT CAAAGTTTAGCTTTTATTCGTAGATCTGATGAATTACTACATAATGTAAATACTGGCAAA TCTACTACAAATATTATGATAACTACAATTATTATAGTAATCATTGTAGTATTGTTATCA TTAATAGCTATTGGTTTACTGTTGTATTGCAAAGCCAAAAACACACCAGTTACACTAAGC AAAGACCAACTAAGTGGAATCAATAATATTGCATTCAGCAAATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P13843 UniProtKB Entry Name FUS_HRSV1 GenBank Protein ID 222565 GenBank Gene ID D00334 - General References
- Johnson PR, Collins PL: The fusion glycoproteins of human respiratory syncytial virus of subgroups A and B: sequence conservation provides a structural basis for antigenic relatedness. J Gen Virol. 1988 Oct;69 ( Pt 10):2623-8. [Article]