Alcohol dehydrogenase [NADP(+)]
Details
- Name
- Alcohol dehydrogenase [NADP(+)]
- Synonyms
- 1.1.1.2
- Aldehyde reductase
- Aldo-keto reductase family 1 member A1
- ALDR1
- ALR
- Gene Name
- AKR1A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017416|Alcohol dehydrogenase [NADP(+)] MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV PMLTVDGKRVPRDAGHPLYPFNDPY
- Number of residues
- 325
- Molecular Weight
- 36572.71
- Theoretical pI
- 6.79
- GO Classification
- Functionsalditol / electron carrier activity / L-glucuronate reductase activityProcessesaldehyde catabolic process / carbohydrate metabolic process / cellular aldehyde metabolic process / D-glucuronate catabolic process / glucose metabolic process / glucuronate catabolic process to xylulose 5-phosphate / glutathione derivative biosynthetic process / L-ascorbic acid biosynthetic process / small molecule metabolic process / xenobiotic metabolic processComponentsapical plasma membrane / cytosol / extracellular exosome / extracellular space
- General Function
- L-glucuronate reductase activity
- Specific Function
- Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
- Pfam Domain Function
- Aldo_ket_red (PF00248)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017417|Alcohol dehydrogenase [NADP(+)] (AKR1A1) ATGGCGGCTTCCTGTGTTCTACTGCACACTGGGCAGAAGATGCCTCTGATTGGTCTGGGT ACCTGGAAGAGTGAGCCTGGTCAGGTAAAAGCAGCTGTTAAGTATGCCCTTAGCGTAGGC TACCGCCACATTGATTGTGCTGCTATCTACGGCAATGAGCCTGAGATTGGGGAGGCCCTG AAGGAGGACGTGGGACCAGGCAAGGCGGTGCCTCGGGAGGAGCTGTTTGTGACATCCAAG CTGTGGAACACCAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACTCTGGCT GACCTCCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTATGCCTTTGAGCGG GGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGC CTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCA GCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC CAAGCACGTGGCCTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGG CGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAG TATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACC TTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTG CCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC TTTAATGACCCGTACTGA
- Chromosome Location
- 1
- Locus
- 1p33-p32
- External Identifiers
Resource Link UniProtKB ID P14550 UniProtKB Entry Name AK1A1_HUMAN GenBank Protein ID 178481 GenBank Gene ID J04794 HGNC ID HGNC:380 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details DB02383 Tolrestat withdrawn unknown Details DB00157 NADH approved, nutraceutical unknown substrate Details DB00997 Doxorubicin approved, investigational no substrate Details DB00898 Ethanol approved unknown substrate Details DB09130 Copper approved, investigational unknown Details DB08904 Certolizumab pegol approved no substrate Details DB06207 Silodosin approved unknown substrate Details DB06077 Lumateperone approved, investigational no substrate Details