Penicillin-binding protein 2x
Details
- Name
- Penicillin-binding protein 2x
- Synonyms
- PBP-2x
- Gene Name
- pbpX
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- Amino acid sequence
>lcl|BSEQ0011713|Penicillin-binding protein 2x MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNFAVIIGTGTRFGTDLAK EAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKILYVEKTQFN KVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITYANMMSIKKELEAAEVKGIDF TTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSGMESSLNSILAGTDGIITYEKDR LGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGE ILATTQRPTFDADTKEGITEDFVWRDILYQSNYEPGSTMKVMMLAAAIDNNTFPGGEVFN SSELKIADATIRDWDVNEGLTGGRTMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLNRFK FGVPTRFGLTDEYAGQLPADNIVNIAQSSFGQGISVTQTQMIRAFTAIANDGVMLEPKFI SAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVP GQNVALKSGTAQIADEKNGGYLVGLTDYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQL GEFANPILERASAMKDSLNLQTTAKALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQP IVVGTGTKIKNSSAEEGKNLAPNQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEF QGSGSTVQKQDVRANTAIKDIKKITLTLGD
- Number of residues
- 750
- Molecular Weight
- 82312.475
- Theoretical pI
- 5.53
- GO Classification
- Functionspenicillin bindingProcessescell cycle / cell division / cell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- Penicillin binding
- Specific Function
- Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
- Pfam Domain Function
- Transmembrane Regions
- 29-49
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011714|Penicillin-binding protein 2x (pbpX) ATGAAGTGGACAAAAAGAGTAATCCGTTATGCGACCAAAAATCGGAAATCGCCGGCTGAA AACAGACGCAGAGTTGGAAAAAGTCTGAGTTTATTATCTGTCTTTGTTTTTGCCATTTTT TTAGTCAATTTTGCGGTCATTATTGGGACAGGCACTCGCTTTGGAACAGATTTAGCGAAG GAAGCTAAGAAGGTTCATCAAACCACCCGTACAGTTCCTGCCAAACGTGGGACTATTTAT GACCGAAATGGAGTCCCGATTGCTGAGGATGCAACCTCCTATAATGTCTATGCGGTCATT GATGAGAACTATAAGTCAGCAACGGGTAAGATTCTTTACGTAGAAAAAACACAATTTAAC AAGGTTGCAGAGGTCTTTCATAAGTATCTGGACATGGAAGAATCCTATGTAAGAGAGCAA CTCTCGCAACCTAATCTCAAGCAAGTTTCCTTTGGAGCAAAGGGAAATGGGATTACCTAT GCCAATATGATGTCTATCAAAAAAGAATTGGAAGCTGCAGAGGTCAAGGGGATTGATTTT ACAACCAGTCCCAATCGTAGTTACCCAAACGGACAATTTGCTTCTAGTTTTATCGGTCTA GCTCAGCTCCATGAAAATGAAGATGGAAGCAAGAGCTTGCTGGGAACCTCTGGAATGGAG AGTTCCTTGAACAGTATTCTTGCAGGGACAGACGGCATTATTACCTATGAAAAGGATCGT CTGGGTAATATTGTACCCGGAACAGAACAAGTTTCCCAACGAACGATGGACGGTAAGGAT GTTTATACAACCATTTCCAGCCCCCTCCAGTCCTTTATGGAAACCCAGATGGATGCTTTT CAAGAGAAGGTAAAAGGAAAGTACATGACAGCGACTTTGGTCAGTGCTAAAACAGGGGAA ATTCTGGCAACAACGCAACGACCGACCTTTGATGCAGATACAAAAGAAGGCATTACAGAG GACTTTGTTTGGCGTGATATCCTTTACCAAAGTAACTATGAGCCAGGTTCCACTATGAAA GTGATGATGTTGGCTGCTGCTATTGATAATAATACCTTTCCAGGAGGAGAAGTCTTTAAT AGTAGTGAGTTAAAAATTGCAGATGCCACGATTCGAGATTGGGACGTTAATGAAGGATTG ACTGGTGGCAGAACGATGACTTTTTCTCAAGGTTTTGCACACTCAAGTAACGTTGGGATG ACCCTCCTTGAGCAAAAGATGGGAGATGCTACCTGGCTTGATTATCTTAATCGTTTTAAA TTTGGAGTTCCGACCCGTTTCGGTTTGACGGATGAGTATGCTGGTCAGCTTCCTGCGGAT AATATTGTCAACATTGCGCAAAGCTCATTTGGACAAGGGATTTCAGTGACCCAGACGCAA ATGATTCGTGCCTTTACAGCTATTGCTAATGACGGTGTCATGCTGGAGCCTAAATTTATT AGTGCCATTTATGATCCAAATGATCAAACTGCTCGGAAATCTCAAAAAGAAATTGTGGGA AATCCTGTTTCTAAAGATGCAGCTAGTCTAACTCGGACTAACATGGTTTTGGTAGGGACG GATCCGGTTTATGGAACCATGTATAACCACAGCACAGGCAAGCCAACTGTAACTGTTCCT GGGCAAAATGTAGCCCTCAAGTCTGGTACGGCTCAGATTGCTGACGAGAAAAATGGTGGT TATCTAGTCGGGTTAACCGACTATATTTTCTCGGCTGTATCGATGAGTCCGGCTGAAAAT CCTGATTTTATCTTGTATGTGACGGTCCAACAACCTGAACATTATTCAGGTATTCAGTTG GGAGAATTTGCCAATCCTATCTTGGAGCGGGCTTCAGCTATGAAAGACTCTCTCAATCTT CAAACAACAGCTAAGGCTTTAGAGCAAGTAAGTCAACAAAGTCCTTATCCTATGCCTAGT GTCAAGGATATTTCACCTGGTGATTTAGCAGAAGAATTGCGTCGCAATCTTGTACAACCC ATCGTTGTGGGAACAGGAACGAAGATTAAAAACAGTTCTGCTGAAGAAGGGAAGAATCTT GCCCCGAACCAGCAAGTCCTTATCTTATCTGATAAAGCAGAGGAGGTTCCAGATATGTAT GGTTGGACAAAGGAGACTGCTGAGACCCTTGCTAAGTGGCTCAATATAGAACTTGAATTT CAAGGTTCGGGCTCTACTGTGCAGAAGCAAGATGTTCGTGCTAACACAGCTATCAAGGAC ATTAAAAAAATTACATTAACTTTAGGAGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P14677 UniProtKB Entry Name PBPX_STRPN GenBank Gene ID AE005672 - General References
- Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]
- Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O: X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Nat Struct Biol. 1996 Mar;3(3):284-9. [Article]