Penicillin-binding protein 2x

Details

Name
Penicillin-binding protein 2x
Synonyms
  • PBP-2x
Gene Name
pbpX
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Amino acid sequence
>lcl|BSEQ0011713|Penicillin-binding protein 2x
MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNFAVIIGTGTRFGTDLAK
EAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKILYVEKTQFN
KVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITYANMMSIKKELEAAEVKGIDF
TTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSGMESSLNSILAGTDGIITYEKDR
LGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGE
ILATTQRPTFDADTKEGITEDFVWRDILYQSNYEPGSTMKVMMLAAAIDNNTFPGGEVFN
SSELKIADATIRDWDVNEGLTGGRTMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLNRFK
FGVPTRFGLTDEYAGQLPADNIVNIAQSSFGQGISVTQTQMIRAFTAIANDGVMLEPKFI
SAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVP
GQNVALKSGTAQIADEKNGGYLVGLTDYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQL
GEFANPILERASAMKDSLNLQTTAKALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQP
IVVGTGTKIKNSSAEEGKNLAPNQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEF
QGSGSTVQKQDVRANTAIKDIKKITLTLGD
Number of residues
750
Molecular Weight
82312.475
Theoretical pI
5.53
GO Classification
Functions
penicillin binding
Processes
cell cycle / cell division / cell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibiotic
Components
integral component of membrane / plasma membrane
General Function
Penicillin binding
Specific Function
Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
Pfam Domain Function
Transmembrane Regions
29-49
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0011714|Penicillin-binding protein 2x (pbpX)
ATGAAGTGGACAAAAAGAGTAATCCGTTATGCGACCAAAAATCGGAAATCGCCGGCTGAA
AACAGACGCAGAGTTGGAAAAAGTCTGAGTTTATTATCTGTCTTTGTTTTTGCCATTTTT
TTAGTCAATTTTGCGGTCATTATTGGGACAGGCACTCGCTTTGGAACAGATTTAGCGAAG
GAAGCTAAGAAGGTTCATCAAACCACCCGTACAGTTCCTGCCAAACGTGGGACTATTTAT
GACCGAAATGGAGTCCCGATTGCTGAGGATGCAACCTCCTATAATGTCTATGCGGTCATT
GATGAGAACTATAAGTCAGCAACGGGTAAGATTCTTTACGTAGAAAAAACACAATTTAAC
AAGGTTGCAGAGGTCTTTCATAAGTATCTGGACATGGAAGAATCCTATGTAAGAGAGCAA
CTCTCGCAACCTAATCTCAAGCAAGTTTCCTTTGGAGCAAAGGGAAATGGGATTACCTAT
GCCAATATGATGTCTATCAAAAAAGAATTGGAAGCTGCAGAGGTCAAGGGGATTGATTTT
ACAACCAGTCCCAATCGTAGTTACCCAAACGGACAATTTGCTTCTAGTTTTATCGGTCTA
GCTCAGCTCCATGAAAATGAAGATGGAAGCAAGAGCTTGCTGGGAACCTCTGGAATGGAG
AGTTCCTTGAACAGTATTCTTGCAGGGACAGACGGCATTATTACCTATGAAAAGGATCGT
CTGGGTAATATTGTACCCGGAACAGAACAAGTTTCCCAACGAACGATGGACGGTAAGGAT
GTTTATACAACCATTTCCAGCCCCCTCCAGTCCTTTATGGAAACCCAGATGGATGCTTTT
CAAGAGAAGGTAAAAGGAAAGTACATGACAGCGACTTTGGTCAGTGCTAAAACAGGGGAA
ATTCTGGCAACAACGCAACGACCGACCTTTGATGCAGATACAAAAGAAGGCATTACAGAG
GACTTTGTTTGGCGTGATATCCTTTACCAAAGTAACTATGAGCCAGGTTCCACTATGAAA
GTGATGATGTTGGCTGCTGCTATTGATAATAATACCTTTCCAGGAGGAGAAGTCTTTAAT
AGTAGTGAGTTAAAAATTGCAGATGCCACGATTCGAGATTGGGACGTTAATGAAGGATTG
ACTGGTGGCAGAACGATGACTTTTTCTCAAGGTTTTGCACACTCAAGTAACGTTGGGATG
ACCCTCCTTGAGCAAAAGATGGGAGATGCTACCTGGCTTGATTATCTTAATCGTTTTAAA
TTTGGAGTTCCGACCCGTTTCGGTTTGACGGATGAGTATGCTGGTCAGCTTCCTGCGGAT
AATATTGTCAACATTGCGCAAAGCTCATTTGGACAAGGGATTTCAGTGACCCAGACGCAA
ATGATTCGTGCCTTTACAGCTATTGCTAATGACGGTGTCATGCTGGAGCCTAAATTTATT
AGTGCCATTTATGATCCAAATGATCAAACTGCTCGGAAATCTCAAAAAGAAATTGTGGGA
AATCCTGTTTCTAAAGATGCAGCTAGTCTAACTCGGACTAACATGGTTTTGGTAGGGACG
GATCCGGTTTATGGAACCATGTATAACCACAGCACAGGCAAGCCAACTGTAACTGTTCCT
GGGCAAAATGTAGCCCTCAAGTCTGGTACGGCTCAGATTGCTGACGAGAAAAATGGTGGT
TATCTAGTCGGGTTAACCGACTATATTTTCTCGGCTGTATCGATGAGTCCGGCTGAAAAT
CCTGATTTTATCTTGTATGTGACGGTCCAACAACCTGAACATTATTCAGGTATTCAGTTG
GGAGAATTTGCCAATCCTATCTTGGAGCGGGCTTCAGCTATGAAAGACTCTCTCAATCTT
CAAACAACAGCTAAGGCTTTAGAGCAAGTAAGTCAACAAAGTCCTTATCCTATGCCTAGT
GTCAAGGATATTTCACCTGGTGATTTAGCAGAAGAATTGCGTCGCAATCTTGTACAACCC
ATCGTTGTGGGAACAGGAACGAAGATTAAAAACAGTTCTGCTGAAGAAGGGAAGAATCTT
GCCCCGAACCAGCAAGTCCTTATCTTATCTGATAAAGCAGAGGAGGTTCCAGATATGTAT
GGTTGGACAAAGGAGACTGCTGAGACCCTTGCTAAGTGGCTCAATATAGAACTTGAATTT
CAAGGTTCGGGCTCTACTGTGCAGAAGCAAGATGTTCGTGCTAACACAGCTATCAAGGAC
ATTAAAAAAATTACATTAACTTTAGGAGACTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP14677
UniProtKB Entry NamePBPX_STRPN
GenBank Gene IDAE005672
General References
  1. Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]
  2. Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O: X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Nat Struct Biol. 1996 Mar;3(3):284-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04918Ceftobiproleapproved, investigationalunknownDetails
DB01150CefprozilapprovedyesinhibitorDetails