Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Details
- Name
- Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
- Synonyms
- ERF3A
- Eukaryotic peptide chain release factor subunit 3a
- G1 to S phase transition protein 1 homolog
- Gene Name
- GSPT1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009369|Eukaryotic peptide chain release factor GTP-binding subunit ERF3A MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKP KSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRET WYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAV LVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEK LVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDG PIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGE NLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCI EEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLR DEGKTIAIGKVLKLVPEKD
- Number of residues
- 499
- Molecular Weight
- 55755.55
- Theoretical pI
- Not Available
- GO Classification
- FunctionsGTP binding / GTPase activity / poly(A) RNA binding / translation release factor activityProcessescytoplasmic translational termination / G1/S transition of mitotic cell cycle / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / protein methylationComponentscytosol / intracellular / translation release factor complex
- General Function
- Translation release factor activity
- Specific Function
- Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0021387|Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) ATGGATCCGGGCAGTGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGGAGCAGCAGCGGC AGCAGCAGCAGCGACTCGGCGCCTGACTGCTGGGACCAGGCGGACATGGAAGCCCCCGGG CCGGGCCCTTGCGGCGGCGGCGGCTCCCTGGCGGCGGCGGCCGAGGCCCAGCGGGAGAAC CTCAGCGCGGCCTTCAGCCGGCAACTCAACGTCAACGCCAAGCCCTTCGTGCCCAACGTC CACGCCGCCGAGTTCGTGCCGTCCTTCCTGCGGGGCCCGGCAGCGCCGCCACCCCCAGCT GGCGGCGCCGCCAATAACCACGGAGCCGGCAGCGGCGCGGGAGGCCGTGCGGCACCTGTG GAATCCTCTCAAGAGGAACAGTCATTGTGTGAAGGTTCAAATTCAGCTGTTAGCATGGAA CTTTCAGAACCTATTGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCAC AAAGAAGAAATAAGTGAAGCAGAGCCAGGGGGTGGTTCCTTGGGAGATGGAAGGCCGCCA GAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTAAGTCTGTG GTTGCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTA GATGCTGGCAAGTCAACCATTGGAGGACAAATAATGTATTTGACTGGAATGGTTGACAAA AGGACGCTTGAAAAGTATGAAAGAGAAGCTAAAGAGAAAAACAGAGAAACTTGGTACTTG TCTTGGGCCTTAGACACAAATCAGGAAGAACGAGACAAGGGTAAAACAGTAGAAGTGGGT CGTGCCTATTTTGAAACCGAAAAGAAGCATTTCACAATTCTAGATGCCCCTGGCCACAAG AGTTTTGTCCCAAATATGATTGGTGGTGCCTCTCAAGCTGATTTGGCTGTGCTGGTAATC TCAGCCAGGAAAGGAGAGTTTGAAACTGGATTTGAAAAAGGAGGACAGACAAGAGAACAT GCAATGTTGGCAAAGACAGCAGGTGTAAAACACCTAATTGTGCTAATTAATAAGATGGAT GATCCAACAGTAAATTGGAGCAATGAGAGATATGAAGAATGTAAGGAGAAACTAGTGCCA TTTTTGAAAAAAGTTGGCTTCAATCCCAAAAAGGACATTCACTTTATGCCCTGCTCAGGA CTTACTGGAGCAAATCTCAAAGAGCAGTCGGATTTCTGTCCTTGGTACATTGGATTACCG TTTATTCCATATCTGGATAATTTGCCGAACTTCAATAGATCAGTTGATGGACCAATCAGG CTGCCAATTGTGGATAAGTACAAGGATATGGGCACTGTGGTCCTGGGAAAGCTGGAATCA GGATCTATTTGTAAAGGCCAGCAGCTTGTGATGATGCCAAACAAGCACAACGTGGAAGTT CTTGGAATACTTTCCGATGATGTAGAGACTGATACCGTAGCCCCAGGTGAAAACCTCAAA ATCAGACTGAAAGGAATTGAAGAAGAGGAGATTCTTCCAGGGTTTATACTTTGTGATCCT AATAATCTTTGTCATTCTGGACGCACATTTGATGCCCAGATAGTGATTATAGAGCACAAA TCCATCATCTGCCCAGGCTATAATGCGGTGCTGCATATTCATACCTGTATTGAGGAGGTG GAAATAACAGCCTTAATCTGCTTGGTAGACAAAAAATCAGGAGAAAAAAGTAAGACCCGA CCCCGTTTTGTCAAACAAGATCAAGTATGCATTGCTCGCTTAAGGACAGCAGGAACCATC TGCCTTGAGACCTTTAAAGACTTCCCTCAGATGGGTCGTTTCACCTTAAGAGATGAGGGT AAGACCATTGCAATTGGAAAAGTTCTGAAACTGGTTCCAGAGAAAGACTAA
- Chromosome Location
- 16
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P15170 UniProtKB Entry Name ERF3A_HUMAN HGNC ID HGNC:4621 - General References
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