Isocitrate dehydrogenase [NADP]

Details

Name
Isocitrate dehydrogenase [NADP]
Synonyms
  • 1.1.1.42
  • IDH
  • Oxalosuccinate decarboxylase
Gene Name
icd
Organism
Azotobacter vinelandii
Amino acid sequence
>lcl|BSEQ0016361|Isocitrate dehydrogenase [NADP]
MSTPKIIYTLTDEAPALATYSLLPIIKAFTGSSGIAVETRDISLAGRLIATFPEYLTDTQ
KISDDLAELGKLATTPDANIIKLPNISASVPQLKAAIKELQQQGYKLPDYPEEPKTDTEK
DVKARYDKIKGSAVNPVLREGNSDRRAPLSVKNYARKHPHKMGAWSADSKSHVAHMDNGD
FYGSEKAALIGAPGSVKIELIAKDGSSTVLKAKTSVQAGEIIDSSVMSKNALRNFIAAEI
EDAKKQGVLLSVHLKATMMKVSDPIMFGQIVSEFYKDALTKHAEVLKQIGFDVNNGIGDL
YARIKTLPEAKQKEIEADIQAVYAQRPQLAMVNSDKGITNLHVPSDVIVDASMPAMIRDS
GKMWGPDGKLHDTKAVIPDRCYAGVYQVVIEDCKQHGAFDPTTMGSVPNVGLMAQKAEEY
GSHDKTFQIPADGVVRVTDESGKLLLEQSVEAGDIWRMCQAKDAPIQDWVKLAVNRARAT
NTPAVFWLDPARAHDAQVIAKVERYLKDYDTSGLDIRILSPVEATRFSLARIREGKDTIS
VTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMSGGGLFETGAGGSAPKHVQQFLEEGYLR
WDSLGEFLALAASLEHLGNAYKNPKALVLASTLDQATGKILDNNKSPARKVGEIDNRGSH
FYLALYWAQALAAQTEDKELQAQFTGIAKALTDNETKIVGELAAAQGKPVDIAGYYHPNT
DLTSKAIRPSATFNAALAPLA
Number of residues
741
Molecular Weight
80388.94
Theoretical pI
6.58
GO Classification
Functions
isocitrate dehydrogenase (NADP+) activity / metal ion binding
Processes
glyoxylate cycle / tricarboxylic acid cycle
Components
cytoplasm
General Function
Metal ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0002466|2226 bp
ATGTCCACACCGAAGATTATCTATACGCTCACTGATGAAGCACCCGCACTGGCGACTTAC
TCTCTGCTTCCCATCATCAAAGCGTTCACCGGATCTTCAGGTATCGCCGTTGAAACCCGC
GATATCTCCCTTGCAGGCCGCCTCATCGCAACCTTCCCCGAATACCTGACCGATACCCAG
AAAATCTCCGACGATTTGGCCGAACTGGGAAAACTGGCCACCACGCCGGACGCCAACATC
ATCAAGCTGCCGAACATCAGCGCCTCCGTCCCGCAACTCAAGGCCGCCATCAAGGAACTG
CAGCAGCAGGGCTACAAGCTCCCGGACTACCCTGAAGAGCCCAAGACCGACACCGAGAAG
GACGTCAAGGCCCGCTACGACAAGATCAAGGGCAGCGCCGTGAACCCCGTCCTGCGCGAA
GGCAACTCCGACCGCCGCGCGCCACTGTCCGTCAAGAACTACGCCAGAAAGCACCCTCAC
AAGATGGGCGCCTGGAGTGCGGACTCCAAGTCCCATGTCGCCCACATGGACAACGGTGAT
TTCTACGGCAGCGAGAAGGCCGCTCTGATTGGCGCCCCCGGCAGTGTGAAAATCGAGCTG
ATCGCCAAAGACGGCAGCAGCACTGTTCTGAAGGCAAAGACCTCTGTTCAGGCTGGCGAG
ATCATCGACTCTTCGGTAATGAGCAAGAACGCCTTGCGCAACTTCATCGCCGCTGAAATC
GAGGATGCGAAGAAGCAGGGAGTACTGCTGTCCGTGCACCTGAAGGCGACCATGATGAAG
GTGTCCGACCCCATCATGTTCGGCCAGATCGTCTCCGAGTTCTACAAGGACGCCCTCACC
AAGCACGCAGAGGTGCTGAAGCAGATCGGCTTCGACGTCAACAATGGCATCGGTGATCTC
TACGCCCGGATCAAGACTCTTCCCGAAGCAAAGCAGAAGGAAATCGAGGCCGACATCCAG
GCGGTTTACGCCCAGCGCCCGCAATTGGCGATGGTGAACTCCGACAAGGGCATCACCAAC
CTGCATGTGCCGAGCGACGTCATCGTCGACGCCTCGATGCCGGCGATGATCCGCGACTCC
GGCAAGATGTGGGGCCCCGACGGCAAGCTGCATGACACCAAGGCGGTCATCCCCGACCGT
TGCTATGCCGGCGTGTACCAGGTGGTCATCGAGGACTGCAAGCAGCACGGCGCCTTCGAC
CCCACCACCATGGGCAGCGTGCCCAACGTCGGTTTGATGGCTCAGAAAGCCGAGGAATAC
GGCTCCCACGACAAGACCTTCCAGATTCCTGCAGACGGCGTGGTCCGTGTGACCGATGAA
AGCGGCAAGCTCTTGCTGGAGCAAAGCGTGGAGGCCGGCGACATTTGGCGCATGTGCCAG
GCGAAAGACGCCCCGATCCAGGACTGGGTCAAGCTGGCCGTCAACCGCGCCCGCGCCACC
AATACCCCGGCGGTGTTCTGGCTGGACCCGGCGCGTGCCCATGATGCCCAGGTTATTGCC
AAGGTCGAGCGTTACCTGAAGGACTACGATACCAGCGGTCTCGACATCCGCATCTTGTCG
CCGGTCGAGGCAACCCGCTTCTCGCTGGCCCGCATCCGCGAAGGCAAGGACACCATTTCC
GTCACCGGCAACGTCCTGCGCGACTACCTGACCGACCTGTTCCCGATCATGGAACTGGGT
ACCAGCGCCAAAATGTTGTCGATCGTCCCGCTGATGAGCGGCGGCGGTCTGTTCGAAACC
GGCGCGGGCGGCTCGGCTCCCAAGCATGTCCAGCAGTTCCTCGAGGAAGGTTACCTGCGT
TGGGATTCGCTCGGCGAGTTCCTCGCTCTTGCCGCATCCCTGGAGCACTTGGGCAACGCC
TACAAGAACCCGAAAGCGCTTGTCCTGGCCAGCACCCTGGACCAGGCTACCGGCAAGATT
CTCGATAACAACAAATCGCCGGCACGTAAGGTTGGCGAGATCGATAACCGCGGTAGCCAC
TTCTACTTGGCACTCTACTGGGCCCAGGCATTGGCAGCGCAAACCGAGGACAAGGAACTG
CAAGCCCAGTTCACCGGCATTGCCAAGGCTCTGACCGACAACGAGACCAAGATCGTCGGC
GAGTTGGCTGCAGCCCAAGGCAAGCCTGTGGATATCGCTGGCTACTACCATCCGAATACC
GACCTGACCAGCAAGGCCATCCGCCCGAGCGCTACTTTCAACGCGGCTCTGGCACCTCTT
GCATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP16100
UniProtKB Entry NameIDH_AZOVI
GenBank Protein ID1030696
GenBank Gene IDD73443
General References
  1. Sahara T, Takada Y, Takeuchi Y, Yamaoka N, Fukunaga N: Cloning, sequencing, and expression of a gene encoding the monomeric isocitrate dehydrogenase of the nitrogen-fixing bacterium, Azotobacter vinelandii. Biosci Biotechnol Biochem. 2002 Mar;66(3):489-500. [Article]
  2. Edwards DJ, Heinrikson RL, Chung AE: Triphosphopyridine nucleotide specific isocitrate dehydrogenase from Azotobacter vinelandii. Alkylation of a specific methionine residue and amino acid sequence of the peptide containing this residue. Biochemistry. 1974 Feb 12;13(4):677-83. [Article]
  3. Yasutake Y, Watanabe S, Yao M, Takada Y, Fukunaga N, Tanaka I: Structure of the monomeric isocitrate dehydrogenase: evidence of a protein monomerization by a domain duplication. Structure. 2002 Dec;10(12):1637-48. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01727Isocitric AcidexperimentalunknownDetails
DB03461Nicotinamide adenine dinucleotide phosphateexperimentalunknownDetails