Atrial natriuretic peptide receptor 3
Details
- Name
- Atrial natriuretic peptide receptor 3
- Synonyms
- ANP-C
- ANPR-C
- ANPRC
- Atrial natriuretic peptide clearance receptor
- Atrial natriuretic peptide receptor type C
- C5orf23
- NPR-C
- NPRC
- Gene Name
- NPR3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004764|Atrial natriuretic peptide receptor 3 MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLP QDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRV AAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPA YAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETK DLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDG SWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEG FHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIA MTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLE ESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSV A
- Number of residues
- 541
- Molecular Weight
- 59807.34
- Theoretical pI
- 6.31
- GO Classification
- FunctionsG-protein coupled peptide receptor activity / hormone binding / natriuretic peptide receptor activity / peptide hormone bindingProcessesadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / cAMP biosynthetic process / cAMP-mediated signaling / negative regulation of adenylate cyclase activity / negative regulation of smooth muscle cell proliferation / osteoclast proliferation / pancreatic juice secretion / phosphatidylinositol-mediated signaling / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of nitric-oxide synthase activity / positive regulation of urine volume / regulation of blood pressure / regulation of osteoblast proliferation / skeletal system developmentComponentsextracellular exosome / integral component of plasma membrane / intracellular / plasma membrane
- General Function
- Peptide hormone binding
- Specific Function
- Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
- Pfam Domain Function
- ANF_receptor (PF01094)
- Transmembrane Regions
- 482-504
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0011737|Atrial natriuretic peptide receptor 3 (NPR3) ATGCCGTCTCTGCTGGTGCTCACTTTCTCCCCGTGCGTACTACTCGGCTGGGCGTTGCTG GCCGGCGGCACCGGTGGCGGTGGCGTTGGCGGCGGCGGCGGTGGCGCGGGCATAGGCGGC GGACGCCAGGAGAGAGAGGCGCTGCCGCCACAGAAGATCGAGGTGCTGGTGTTACTGCCC CAGGATGACTCGTACTTGTTTTCACTCACCCGGGTGCGGCCGGCCATCGAGTATGCTCTG CGCAGCGTGGAGGGCAACGGGACTGGGAGGCGGCTTCTGCCGCCGGGCACTCGCTTCCAG GTGGCTTACGAGGATTCAGACTGTGGGAACCGTGCGCTCTTCAGCTTGGTGGACCGCGTG GCGGCGGCGCGGGGCGCCAAGCCAGACCTTATCCTGGGGCCAGTGTGCGAGTATGCAGCA GCGCCAGTGGCCCGGCTTGCATCGCACTGGGACCTGCCCATGCTGTCGGCTGGGGCGCTG GCCGCTGGCTTCCAGCACAAGGACTCTGAGTACTCGCACCTCACGCGCGTGGCGCCCGCC TACGCCAAGATGGGCGAGATGATGCTCGCCCTGTTCCGCCACCACCACTGGAGCCGCGCT GCACTGGTCTACAGCGACGACAAGCTGGAGCGGAACTGCTACTTCACCCTCGAGGGGGTC CACGAGGTCTTCCAGGAGGAGGGTTTGCACACGTCCATCTACAGTTTCGACGAGACCAAA GACTTGGATCTGGAAGACATCGTGCGCAATATCCAGGCCAGTGAGAGAGTGGTGATCATG TGTGCGAGCAGTGACACCATCCGGAGCATCATGCTGGTGGCGCACAGGCATGGCATGACC AGTGGAGACTACGCCTTCTTCAACATTGAGCTCTTCAACAGCTCTTCCTATGGAGATGGC TCATGGAAGAGAGGAGACAAACACGACTTTGAAGCTAAGCAAGCATACTCGTCCCTCCAG ACAGTCACTCTACTGAGGACAGTGAAACCTGAGTTTGAGAAGTTTTCCATGGAGGTGAAA AGTTCAGTTGAGAAACAAGGGCTCAATATGGAGGATTACGTTAACATGTTTGTTGAAGGA TTCCACGATGCCATCCTCCTCTACGTCTTGGCTCTACATGAAGTACTCAGAGCTGGTTAC AGCAAAAAGGATGGAGGGAAAATTATACAGCAGACTTGGAACAGAACATTTGAAGGTATC GCCGGGCAGGTGTCCATAGATGCCAACGGAGACCGATATGGGGATTTCTCTGTGATTGCC ATGACTGATGTGGAGGCGGGCACCCAGGAGGTTATTGGTGATTATTTTGGAAAAGAAGGT CGTTTTGAAATGCGGCCGAATGTCAAATATCCTTGGGGCCCTTTAAAACTGAGAATAGAT GAAAACCGAATTGTAGAGCATACAAACAGCTCTCCCTGCAAATCATGTGGCCTAGAAGAA TCGGCAGTGACAGGAATTGTCGTGGGGGCTTTACTAGGAGCTGGCTTGCTAATGGCCTTC TACTTTTTCAGGAAGAAATACAGAATAACCATTGAGAGGCGAACCCAGCAAGAAGAAAGT AACCTTGGAAAACATCGGGAATTACGGGAAGATTCCATCAGATCCCATTTTTCAGTAGCT TAA
- Chromosome Location
- 5
- Locus
- 5p14-p13
- External Identifiers
Resource Link UniProtKB ID P17342 UniProtKB Entry Name ANPRC_HUMAN GenBank Gene ID X52282 GenAtlas ID NPR3 HGNC ID HGNC:7945 - General References
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