Myosin regulatory light chain 12A
Details
- Name
- Myosin regulatory light chain 12A
- Synonyms
- Epididymis secretory protein Li 24
- HEL-S-24
- MLC-2B
- MLCB
- MRLC3
- Myosin regulatory light chain 2, nonsarcomeric
- Myosin regulatory light chain MRLC3
- Myosin RLC
- RLC
- Gene Name
- MYL12A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012994|Myosin regulatory light chain 12A MSSKRTKTKTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASL GKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQED YLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
- Number of residues
- 171
- Molecular Weight
- 19793.96
- Theoretical pI
- 4.4
- GO Classification
- Functionscalcium ion bindingProcessesaxon guidance / ephrin receptor signaling pathway / muscle contraction / platelet aggregationComponentscytosol / extracellular exosome / myosin complex
- General Function
- Calcium ion binding
- Specific Function
- Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
- Pfam Domain Function
- EF-hand_7 (PF13499)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012995|Myosin regulatory light chain 12A (MYL12A) ATGTCGAGCAAAAGAACAAAGACCAAGACCAAGAAGCGCCCTCAGCGTGCAACATCCAAT GTGTTTGCTATGTTTGACCAGTCACAGATTCAGGAGTTCAAAGAGGCCTTCAACATGATT GATCAGAACAGAGATGGTTTCATCGACAAGGAAGATTTGCATGATATGCTTGCTTCATTG GGGAAGAATCCAACTGATGAGTATCTAGATGCCATGATGAATGAGGCTCCAGGCCCCATC AATTTCACCATGTTCCTCACCATGTTTGGTGAGAAGTTAAATGGCACAGATCCTGAAGAT GTCATCAGAAATGCCTTTGCTTGCTTTGATGAAGAAGCAACTGGCACCATACAGGAAGAT TACTTGAGAGAGCTGCTGACAACCATGGGGGATCGGTTTACAGATGAGGAAGTGGATGAG CTGTACAGAGAAGCACCTATTGATAAAAAGGGGAATTTCAATTACATCGAGTTCACACGC ATCCTGAAACATGGAGCCAAAGACAAAGATGACTGA
- Chromosome Location
- 18
- Locus
- 18p11.31
- External Identifiers
Resource Link UniProtKB ID P19105 UniProtKB Entry Name ML12A_HUMAN GenBank Protein ID 34756 GenBank Gene ID X54304 HGNC ID HGNC:16701 - General References
- Grant JW, Zhong RQ, McEwen PM, Church SL: Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA. Nucleic Acids Res. 1990 Oct 11;18(19):5892. [Article]
- Iwasaki T, Murata-Hori M, Ishitobi S, Hosoya H: Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. Cell Struct Funct. 2001 Dec;26(6):677-83. [Article]
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