Genome polyprotein

Details

Name
Genome polyprotein
Synonyms
  • 3.4.22.-
  • N-pro
Gene Name
Not Available
Organism
BVDV
Amino acid sequence
>lcl|BSEQ0021309|Genome polyprotein
MELITNELLYKTYKQKPVGVEEPVYDQAGDPLFGERGAVHPQSTLKLPHKRGERDVPTNL
ASLPKRGDCRSGNSRGPVSGIYLKPGPLFYQDYKGPVYHRAPLELFEEGSMCETTKRIGR
VTGSDGKLYHIYVCIDGCIIIKSATRSYQRVFRWVHNRLDCPLWVTTCSDTKEEGATKKK
TQKPDRLERGKMKIVPKESEKDSKTKPPDATIVVEGVKYQVRKKGKTKSKNTQDGLYHNK
NKPQESRKKLEKALLAWAIIAIVLFQVTMGENITQWNLQDNGTEGIQRAMFQRGVNRSLH
GIWPEKICTGVPSHLATDIELKTIHGMMDASEKTNYTCCRLQRHEWNKHGWCNWYNIEPW
ILVMNRTQANLTEGQPPRECAVTCRYDRASDLNVVTQARDSPTPLTGCKKGKNFSFAGIL
MRGPCNFEIAASDVLFKEHERISMFQDTTLYLVDGLTNSLEGARQGTAKLTTWLGKQLGI
LGKKLENKSKTWFGAYAASPYCDVDRKIGYIWYTKNCTPACLPKNTKIVGPGKFGTNAED
GKILHEMGGHLSEVLLLSLVVLSDFAPETASVMYLILHFSIPQSHVDVMDCDKTQLNLTV
ELTTAEVIPGSVWNLGKYVCIRPNWWPYETTVVLAFEEVSQVVKLVLRALRDLTRIWNAA
TTTAFLVCLVKIVRGQMVQGILWLLLITGVQGHLDCKPEFSYAIAKDERIGQLGAEGLTT
TWKEYSPGMKLEDTMVIAWCEDGKLMYLQRCTRETRYLAILHTRALPTSVVFKKLFDGRK
QEDVVEMNDNFEFGLCPCDAKPIVRGKFNTTLLNGPAFQMVCPIGWTGTVSCTSFNMDTL
ATTVVRTYRRSKPFPHRQGCITQKNLGEDLHNCILGGNWTCVPGDQLLYKGGSIESCKWC
GYQFKESEGLPHYPIGKCKLENETGYRLVDSTSCNREGVAIVPQGTLKCKIGKTTVQVIA
MDTKLGPMPCRPYEIISSEGPVEKTACTFNYTKTLKNKYFEPRDSYFQQYMLKGEYQYWF
DLEVTDHHRDYFAESILVVVVALLGGRYVLWLLVTYMVLSEQKALGIQYGSGEVVMMGNL
LTHNNIEVVTYFLLLYLLLREESVKKWVLLLYHILVVHPIKSVIVILLMIGDVVKADSGG
QEYLGKIDLCFTTVVLIVIGLIIARRDPTIVPLVTIMAALRVTELTHQPGVDIAVAVMTI
TLLMVSYVTDYFRYKKWLQCILSLVSAVFLIRSLIYLGRIEMPEVTIPNWRPLTLILLYL
ISTTIVTRWKVDVAGLLLQCVPILLLVTTLWADFLTLILILPTYELVKLYYLKTVRTDTE
RSWLGGIDYTRVDSIYDVDESGEGVYLFPSRQKAQGNFSILLPLIKATLISCVSSKWQLI
YMSYLTLDFMYYMHRKVIEEISGGTNIISRLVAALIELNWSMEEEESKGLKKFYLLSGRL
RNLIIKHKVRNETVASWYGEEEVYGMPKIMTIIKASTLSKSRHCIICTVCEGREWKGGTC
PKCGRHGKPITCGMSLADFEERHYKRIFIREGNFEGMCSRCQGKHRRFEMDREPKSARYC
AECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEWAGCQRVGISPDTHRVPCHI
SFGSRMPFRQEYNGFVQYTARGQLFLRNLPVLATKVKMLMVGNLGEEIGNLEHLGWILRG
PAVCKKITEHEKCHINILDKLTAFFGIMPRGTTPRAPVRFPTSLLKVRRGLETAWAYTHQ
GGISSVDHVTAGKDLLVCDSMGRTRVVCQSNNRLTDETEYGVKTDSGCPDGARCYVLNPE
AVNISGSKGAVVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKV
GKNEESKPTKIMSGIQTVSKNRADLTEMVKKITSMNRGDFKQITLATGAGKTTELPKAVI
EEIGRHKRVLVLIPLRAAAESVYQYMRLKHPSISFNLRIGDMKEGDMATGITYASYGYFC
QMPQPKLRAAMVEYSYIFLDEYHCATPEQLAIIGKIHRFSESIRVVAMTATPAGSVTTTG
QKHPIEEFIAPEVMKGEDLGSQFLDIAGLKIPVDEMKGNMLVFVPTRNMAVEVAKKLKAK
GYNSGYYYSGEDPANLRVVTSQSPYVIVATNAIESGVTLPDLDTVIDTGLKCEKRVRVSS
KIPFIVTGLKRMAVTVGEQAQRRGRVGRVKPGRYYRSQETATGSKDYHYDLLQAQRYGIE
DGINVTKSFREMNYDWSLYEEDSLLITQLEILNNLLISEDLPAAVKNIMARTDHPEPIQL
AYNSYEVQVPVLFPKIRNGEVTDTYENYSFLNARKLGEDVPVYIYATEDEDLAVDLLGLD
WPDPGNQQVVETGKALKQVTGLSSAENALLVALFGYVGYQALSKRHVPMITDIYTIEDQR
LEDTTHLQYAPNAIKTDGTETELKELASGDVEKIMGAISDYAAGGLEFVKSQAEKIKTAP
LFKENAEAAKGYVQKFIDSLIENKEEIIRYGLWGTHTALYKSIAARLGHETAFATLVLKW
LAFGGESVSDHVKQAAVDLVVYYVMNKPSFPGDSETQQEGRRFVASLFISALATYTYKTW
NYHNLSKVVEPALAYLPYATSALKMFTPTRLESVVILSTTIYKTYLSIRKGKSDGLLGTG
ISAAMEILSQNPVSVGISVMLGVGAIAAHNAIESSEQKRTLLMKVFVKNFLDQAATDELV
KENPEKIIMALFEAVQTIGNPLRLIYHLYGVYYKGWEAKELSERTAGRNLFTLIMFEAFE
LLGMDSQGKIRNLSGNYILDLIYGLHKQINRGLKKMVLGWAPAPFSCDWTPSDERIRLPT
DNYLRVETRCPCGYEMKAFKNVGGKLTKVEESGPFLCRNRPGRGPVNYRVTKYYDDNLRE
IKPVAKLEGQVEHYYKGVTAKIDYSKGKMLLATDKWEVEHGVITRLAKRYTGVGFNGAYL
GDEPNHRALVERDCATITKNTVQFLKMKKGCAFTYDLTISNLTRLIELVHRNNLEEKEIP
TATVTTWLAYTFVNEDVGTIKPVLGERVIPDPVVDINLQPEVQVDTSEVGITIIGRETLM
TTGVTPVLEKVEPDASDNQNSVKIGLDEGNYPGPGIQTHTLTEEIHNRDARPFIMILGSR
NSISNRAKTARNINLYTGNDPREIRDLMAAGRMLVVALRDVDPELSEMVDFKGTFLDREA
LEALSLGQPKPKQVTKEAVRNLIEQKKDVEIPNWFASDDPVFLEVALKNDKYYLVGDVGE
LKDQAKALGATDQTRIIKEVGSRTYAMKLSSWFLKASNKQMSLTPLFEELLLRCPPATKS
NKGHMASAYQLAQGNWEPLGCGVHLGTIPARRVKIHPYEAYLKLKDFIEEEEKKPRVKDT
VIREHNKWILKKIRFQGNLNTKKMLNPGKLSEQLDREGRKRNIYNHQIGTIMSSAGIRLE
KLPIVRAQTDTKTFHEAIRDKIDKSENRQNPELHNKLLEIFHTIAQPTLKHTYGEVTWEQ
LEAGVNRKGAAGFLEKKNIGEVLDSEKHLVEQLVRDLKAGRKIKYYETAIPKNEKRDVSD
DWQAGDLVVEKRPRVIQYPEAKTRLAITKVMYNWVKQQPVVIPGYEGKTPLFNIFDKVRK
EWDSFNEPVAVSFDTKAWDTQVTSKDLQLIGEIQKYYYKKEWHKFIDTITDHMTEVPVIT
ADGEVYIRNGQRGSGQPDTSAGNSMLNVLTMMYGFCESTGVPYKSFNRVARIHVCGDDGF
LITEKGLGLKFANKGMQILHEAGKPQKITEGEKMKVAYRFEDIEFCSHTPVPVRWSDNTS
SHMAGRDTAVILSKMATRLDSSGERGTTAYEKAVAFSFLLMYSWNPLVRRICLLVLSQQP
ETDPSKHATYYYKGDPIGAYKDVIGRNLSELKRTGFEKLANLNLSLSTLGVWTKHTSKRI
IQDCVAIGKEEGNWLVKPDRLISSKTGHLYIPDKGFTLQGKHYEQLQLRTETNPVMGVGT
ERYKLGPIVNLLLRRLKILLMTAVGVSS
Number of residues
3988
Molecular Weight
449159.405
Theoretical pI
8.73
GO Classification
Functions
ATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / ribonuclease T2 activity / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / serine-type exopeptidase activity
Processes
clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / pore formation by virus in membrane of host cell / protein oligomerization / suppression by virus of host IRF3 activity / viral protein processing / viral RNA genome replication / virion attachment to host cell
Components
host cell cytoplasm / host cell cytoplasmic vesicle / host cell Golgi apparatus / host cell mitochondrion / host cell nucleus / host cell surface / integral component of membrane / integral to membrane of host cell / virion membrane
General Function
Serine-type exopeptidase activity
Specific Function
Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (Probable).P7 forms a leader sequence to properly orient NS2 in the membrane.Uncleaved NS2-3 is required for production of infectious virus.NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.NS4A is a cofactor for the NS3 protease activity.RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
Pfam Domain Function
Transmembrane Regions
1144-1164 1189-1209 1217-1237 1247-1267 1281-1301 1360-1380 1658-1678
Cellular Location
Host membrane
Gene sequence
>lcl|BSEQ0021310|Genome polyprotein
ATGGAGTTGATCACAAATGAACTTTTATACAAAACATACAAACAAAAACCCGTCGGGGTG
GAGGAACCTGTTTATGATCAGGCAGGTGATCCCTTATTTGGTGAAAGGGGAGCAGTCCAC
CCTCAATCGACGCTAAAGCTCCCACACAAGAGAGGGGAACGCGATGTTCCAACCAACTTG
GCATCCTTACCAAAAAGAGGTGACTGCAGGTCGGGTAATAGCAGAGGACCTGTGAGCGGG
ATCTACCTGAAGCCAGGGCCACTATTTTACCAGGACTATAAAGGTCCCGTCTATCACAGG
GCCCCGCTGGAGCTCTTTGAGGAGGGATCCATGTGTGAAACGACTAAACGGATAGGGAGA
GTAACTGGAAGTGACGGAAAGCTGTACCACATTTATGTGTGTATAGATGGATGTATAATA
ATAAAAAGTGCCACGAGAAGTTACCAAAGGGTGTTCAGGTGGGTCCATAATAGGCTTGAC
TGCCCTCTATGGGTCACAACTTGCTCAGACACGAAAGAAGAGGGAGCAACAAAAAAGAAA
ACACAGAAACCCGACAGACTAGAAAGGGGGAAAATGAAAATAGTGCCCAAAGAATCTGAA
AAAGACAGCAAAACTAAACCTCCGGATGCTACAATAGTGGTGGAAGGAGTCAAATACCAG
GTGAGGAAGAAGGGAAAAACCAAGAGTAAAAACACTCAGGACGGCTTGTACCATAACAAA
AACAAACCTCAGGAATCACGCAAGAAACTGGAAAAAGCATTGTTGGCGTGGGCAATAATA
GCTATAGTTTTGTTTCAAGTTACAATGGGAGAAAACATAACACAGTGGAACCTACAAGAT
AATGGGACGGAAGGGATACAACGGGCAATGTTCCAAAGGGGTGTGAATAGAAGTTTACAT
GGAATCTGGCCAGAGAAAATCTGTACTGGCGTCCCTTCCCATCTAGCCACCGATATAGAA
CTAAAAACAATTCATGGTATGATGGATGCAAGTGAGAAGACCAACTACACGTGTTGCAGA
CTTCAACGCCATGAGTGGAACAAGCATGGTTGGTGCAACTGGTACAATATTGAACCCTGG
ATTCTAGTCATGAATAGAACCCAAGCCAATCTCACTGAGGGACAACCACCAAGGGAGTGC
GCAGTCACTTGTAGGTATGATAGGGCTAGTGACTTAAACGTGGTAACACAAGCTAGAGAT
AGCCCCACACCCTTAACAGGTTGCAAGAAAGGAAAGAACTTCTCCTTTGCAGGCATATTG
ATGCGGGGCCCCTGCAACTTTGAAATAGCTGCAAGTGATGTATTATTCAAAGAACATGAA
CGCATTAGTATGTTCCAGGATACCACTCTTTACCTTGTTGACGGGTTGACCAACTCCTTA
GAAGGTGCCAGACAAGGAACCGCTAAACTGACAACCTGGTTAGGCAAGCAGCTCGGGATA
CTAGGAAAAAAGTTGGAAAACAAGAGTAAGACGTGGTTTGGAGCATACGCTGCTTCCCCT
TACTGTGATGTCGATCGCAAAATTGGCTACATATGGTATACAAAAAATTGCACCCCTGCC
TGCTTACCCAAGAACACAAAAATTGTCGGCCCTGGGAAATTTGGCACCAATGCAGAGGAC
GGCAAGATATTACATGAGATGGGGGGTCACTTGTCGGAGGTACTACTACTTTCTTTAGTG
GTGCTGTCCGACTTCGCACCGGAAACAGCTAGTGTAATGTACCTAATCCTACATTTTTCC
ATCCCACAAAGTCACGTTGATGTAATGGATTGTGATAAGACCCAGTTGAACCTCACAGTG
GAGCTGACAACAGCTGAAGTAATACCAGGGTCGGTCTGGAATCTAGGCAAATATGTATGT
ATAAGACCAAATTGGTGGCCTTATGAGACAACTGTAGTGTTGGCATTTGAAGAGGTGAGC
CAGGTGGTGAAGTTAGTGTTGAGGGCACTCAGAGATTTAACACGCATTTGGAACGCTGCA
ACAACTACTGCTTTTTTAGTATGCCTTGTTAAGATAGTCAGGGGCCAGATGGTACAGGGC
ATTCTGTGGCTACTATTGATAACAGGGGTACAAGGGCACTTGGATTGCAAACCTGAATTC
TCGTATGCCATAGCAAAGGACGAAAGAATTGGTCAACTGGGGGCTGAAGGCCTTACCACC
ACTTGGAAGGAATACTCACCTGGAATGAAGCTGGAAGACACAATGGTCATTGCTTGGTGC
GAAGATGGGAAGTTAATGTACCTCCAAAGATGCACGAGAGAAACCAGATATCTCGCAATC
TTGCATACAAGAGCCTTGCCGACCAGTGTGGTATTCAAAAAACTCTTTGATGGGCGAAAG
CAAGAGGATGTAGTCGAAATGAACGACAACTTTGAATTTGGACTCTGCCCATGTGATGCC
AAACCCATAGTAAGAGGGAAGTTCAATACAACGCTGCTGAACGGACCGGCCTTCCAGATG
GTATGCCCCATAGGATGGACAGGGACTGTAAGCTGTACGTCATTCAATATGGACACCTTA
GCCACAACTGTGGTACGGACATATAGAAGGTCTAAACCATTCCCTCATAGGCAAGGCTGT
ATCACCCAAAAGAATCTGGGGGAGGATCTCCATAACTGCATCCTTGGAGGAAATTGGACT
TGTGTGCCTGGAGACCAACTACTATACAAAGGGGGCTCTATTGAATCTTGCAAGTGGTGT
GGCTATCAATTTAAAGAGAGTGAGGGACTACCACACTACCCCATTGGCAAGTGTAAATTG
GAGAACGAGACTGGTTACAGGCTAGTAGACAGTACCTCTTGCAATAGAGAAGGTGTGGCC
ATAGTACCACAAGGGACATTAAAGTGCAAGATAGGAAAAACAACTGTACAGGTCATAGCT
ATGGATACCAAACTCGGACCTATGCCTTGCAGACCATATGAAATCATATCAAGTGAGGGG
CCTGTAGAAAAGACAGCGTGTACTTTCAACTACACTAAGACATTAAAAAATAAGTATTTT
GAGCCCAGAGACAGCTACTTTCAGCAATACATGCTAAAAGGAGAGTATCAATACTGGTTT
GACCTGGAGGTGACTGACCATCACCGGGATTACTTCGCTGAGTCCATATTAGTGGTGGTA
GTAGCCCTCTTGGGTGGCAGATATGTACTTTGGTTACTGGTTACATACATGGTCTTATCA
GAACAGAAGGCCTTAGGGATTCAGTATGGATCAGGGGAAGTGGTGATGATGGGCAACTTG
CTAACCCATAACAATATTGAAGTGGTGACATACTTCTTGCTGCTGTACCTACTGCTGAGG
GAGGAGAGCGTAAAGAAGTGGGTCTTACTCTTATACCACATCTTAGTGGTACACCCAATC
AAATCTGTAATTGTGATCCTACTGATGATTGGGGATGTGGTAAAGGCCGATTCAGGGGGC
CAAGAGTACTTGGGGAAAATAGACCTCTGTTTTACAACAGTAGTACTAATCGTCATAGGT
TTAATCATAGCTAGGCGTGACCCAACTATAGTGCCACTGGTAACAATAATGGCAGCACTG
AGGGTCACTGAACTGACCCACCAGCCTGGAGTTGACATCGCTGTGGCGGTCATGACTATA
ACCCTACTGATGGTTAGCTATGTGACAGATTATTTTAGATATAAAAAATGGTTACAGTGC
ATTCTCAGCCTGGTATCTGCGGTGTTCTTGATAAGAAGCCTAATATACCTAGGTAGAATC
GAGATGCCAGAGGTAACTATCCCAAACTGGAGACCACTAACTTTAATACTATTATATTTG
ATCTCAACAACAATTGTAACGAGGTGGAAGGTTGACGTGGCTGGCCTATTGTTGCAATGT
GTGCCTATCTTATTGCTGGTCACAACCTTGTGGGCCGACTTCTTAACCCTAATACTGATC
CTGCCTACCTATGAATTGGTTAAATTATACTATCTGAAAACTGTTAGGACTGATACAGAA
AGAAGTTGGCTAGGGGGGATAGACTATACAAGAGTTGACTCCATCTACGACGTTGATGAG
AGTGGAGAGGGCGTATATCTTTTTCCATCAAGGCAGAAAGCACAGGGGAATTTTTCTATA
CTCTTGCCCCTTATCAAAGCAACACTGATAAGTTGCGTCAGCAGTAAATGGCAGCTAATA
TACATGAGTTACTTAACTTTGGACTTTATGTACTACATGCACAGGAAAGTTATAGAAGAG
ATCTCAGGAGGTACCAACATAATATCCAGGTTAGTGGCAGCACTCATAGAGCTGAACTGG
TCCATGGAAGAAGAGGAGAGCAAAGGCTTAAAGAAGTTTTATCTATTGTCTGGAAGGTTG
AGAAACCTAATAATAAAACATAAGGTAAGGAATGAGACCGTGGCTTCTTGGTACGGGGAG
GAGGAAGTCTACGGTATGCCAAAGATCATGACTATAATCAAGGCCAGTACACTGAGTAAG
AGCAGGCACTGCATAATATGCACTGTATGTGAGGGCCGAGAGTGGAAAGGTGGCACCTGC
CCAAAATGTGGACGCCATGGGAAGCCGATAACGTGTGGGATGTCGCTAGCAGATTTTGAA
GAAAGACACTATAAAAGAATCTTTATAAGGGAAGGCAACTTTGAGGGTATGTGCAGCCGA
TGCCAGGGAAAGCATAGGAGGTTTGAAATGGACCGGGAACCTAAGAGTGCCAGATACTGT
GCTGAGTGTAATAGGCTGCATCCTGCTGAGGAAGGTGACTTTTGGGCAGAGTCGAGCATG
TTGGGCCTCAAAATCACCTACTTTGCGCTGATGGATGGAAAGGTGTATGATATCACAGAG
TGGGCTGGATGCCAGCGTGTGGGAATCTCCCCAGATACCCACAGAGTCCCTTGTCACATC
TCATTTGGTTCACGGATGCCTTTCAGGCAGGAATACAATGGCTTTGTACAATATACCGCT
AGGGGGCAACTATTTCTGAGAAACTTGCCCGTACTGGCAACTAAAGTAAAAATGCTCATG
GTAGGCAACCTTGGAGAAGAAATTGGTAATCTGGAACATCTTGGGTGGATCCTAAGGGGG
CCTGCCGTGTGTAAGAAGATCACAGAGCACGAAAAATGCCACATTAATATACTGGATAAA
CTAACCGCATTTTTCGGGATCATGCCAAGGGGGACTACACCCAGAGCCCCGGTGAGGTTC
CCTACGAGCTTACTAAAAGTGAGGAGGGGTCTGGAGACTGCCTGGGCTTACACACACCAA
GGCGGGATAAGTTCAGTCGACCATGTAACCGCCGGAAAAGATCTACTGGTCTGTGACAGC
ATGGGACGAACTAGAGTGGTTTGCCAAAGCAACAACAGGTTGACCGATGAGACAGAGTAT
GGCGTCAAGACTGACTCAGGGTGCCCAGACGGTGCCAGATGTTATGTGTTAAATCCAGAG
GCCGTTAACATATCAGGATCCAAAGGGGCAGTCGTTCACCTCCAAAAGACAGGTGGAGAA
TTCACGTGTGTCACCGCATCAGGCACACCGGCTTTCTTCGACCTAAAAAACTTGAAAGGA
TGGTCAGGCTTGCCTATATTTGAAGCCTCCAGCGGGAGGGTGGTTGGCAGAGTCAAAGTA
GGGAAGAATGAAGAGTCTAAACCTACAAAAATAATGAGTGGAATCCAGACCGTCTCAAAA
AACAGAGCAGACCTGACCGAGATGGTCAAGAAGATAACCAGCATGAACAGGGGAGACTTC
AAGCAGATTACTTTGGCAACAGGGGCAGGCAAAACCACAGAACTCCCAAAAGCAGTTATA
GAGGAGATAGGAAGACACAAGAGAGTATTAGTTCTTATACCATTAAGGGCAGCGGCAGAG
TCAGTCTACCAGTATATGAGATTGAAACACCCAAGCATCTCTTTTAACCTAAGGATAGGG
GACATGAAAGAGGGGGACATGGCAACCGGGATAACCTATGCATCATACGGGTACTTCTGC
CAAATGCCTCAACCAAAGCTCAGAGCTGCTATGGTAGAATACTCATACATATTCTTAGAT
GAATACCATTGTGCCACTCCTGAACAACTGGCAATTATCGGGAAGATCCACAGATTTTCA
GAGAGTATAAGGGTTGTCGCCATGACTGCCACGCCAGCAGGGTCGGTGACCACAACAGGT
CAAAAGCACCCAATAGAGGAATTCATAGCCCCCGAGGTAATGAAAGGGGAGGATCTTGGT
AGTCAGTTCCTTGATATAGCAGGGTTAAAAATACCAGTGGATGAGATGAAAGGCAATATG
TTGGTTTTTGTACCAACGAGAAACATGGCAGTAGAGGTAGCAAAGAAGCTAAAAGCTAAG
GGCTATAACTCTGGATACTATTACAGTGGAGAGGATCCAGCCAATCTGAGAGTTGTGACA
TCACAATCCCCCTATGTAATCGTGGCTACAAATGCTATTGAATCAGGAGTGACACTACCA
GATTTGGACACGGTTATAGACACGGGGTTGAAATGTGAAAAGAGGGTGAGGGTATCATCA
AAGATACCCTTCATCGTAACAGGCCTTAAGAGGATGGCCGTGACTGTGGGTGAGCAGGCG
CAGCGTAGGGGCAGAGTAGGTAGAGTGAAACCCGGGAGGTATTATAGGAGCCAGGAAACA
GCAACAGGGTCAAAGGACTACCACTATGACCTCTTGCAGGCACAAAGATACGGGATTGAG
GATGGAATCAACGTGACGAAATCCTTTAGGGAGATGAATTACGATTGGAGCCTATACGAG
GAGGACAGCCTACTAATAACCCAGCTGGAAATACTAAATAATCTACTCATCTCAGAAGAC
TTGCCAGCCGCTGTTAAGAACATAATGGCCAGGACTGATCACCCAGAGCCAATCCAACTT
GCATACAACAGCTATGAAGTCCAGGTCCCGGTCCTATTCCCAAAAATAAGGAATGGAGAA
GTCACAGACACCTACGAAAATTACTCGTTTCTAAATGCCAGAAAGTTAGGGGAGGATGTG
CCCGTGTATATCTACGCTACTGAAGATGAGGATCTGGCAGTTGACCTCTTAGGGCTAGAC
TGGCCTGATCCTGGGAACCAGCAGGTAGTGGAGACTGGTAAAGCACTGAAGCAAGTGACC
GGGTTGTCCTCGGCTGAAAATGCCCTACTAGTGGCTTTATTTGGGTATGTGGGTTACCAG
GCTCTCTCAAAGAGGCATGTCCCAATGATAACAGACATATATACCATCGAGGACCAGAGA
CTAGAAGACACCACCCACCTCCAGTATGCACCCAACGCCATAAAAACCGATGGGACAGAG
ACTGAACTGAAAGAACTGGCGTCGGGTGACGTGGAAAAAATCATGGGAGCCATTTCAGAT
TATGCAGCTGGGGGACTGGAGTTTGTTAAATCCCAAGCAGAAAAGATAAAAACAGCTCCT
TTGTTTAAAGAAAACGCAGAAGCCGCAAAAGGGTATGTCCAAAAATTCATTGACTCATTA
ATTGAAAATAAAGAAGAAATAATCAGATATGGTTTGTGGGGAACACACACAGCACTATAC
AAAAGCATAGCTGCAAGACTGGGGCATGAAACAGCGTTTGCCACACTAGTGTTAAAGTGG
CTAGCTTTTGGAGGGGAATCAGTGTCAGACCACGTCAAGCAGGCGGCAGTTGATTTAGTG
GTCTATTATGTGATGAATAAGCCTTCCTTCCCAGGTGACTCCGAGACACAGCAAGAAGGG
AGGCGATTCGTCGCAAGCCTGTTCATCTCCGCACTGGCAACCTACACATACAAAACTTGG
AATTACCACAATCTCTCTAAAGTGGTGGAACCAGCCCTGGCTTACCTCCCCTATGCTACC
AGCGCATTAAAAATGTTCACCCCAACGCGGCTGGAGAGCGTGGTGATACTGAGCACCACG
ATATATAAAACATACCTCTCTATAAGGAAGGGGAAGAGTGATGGATTGCTGGGTACGGGG
ATAAGTGCAGCCATGGAAATCCTGTCACAAAACCCAGTATCGGTAGGTATATCTGTGATG
TTGGGGGTAGGGGCAATCGCTGCGCACAACGCTATTGAGTCCAGTGAACAGAAAAGGACC
CTACTTATGAAGGTGTTTGTAAAGAACTTCTTGGATCAGGCTGCAACAGATGAGCTGGTA
AAAGAAAACCCAGAAAAAATTATAATGGCCTTATTTGAAGCAGTCCAGACAATTGGTAAC
CCCCTGAGACTAATATACCACCTGTATGGGGTTTACTACAAAGGTTGGGAGGCCAAGGAA
CTATCTGAGAGGACAGCAGGCAGAAACTTATTCACATTGATAATGTTTGAAGCCTTCGAG
TTATTAGGGATGGACTCACAAGGGAAAATAAGGAACCTGTCCGGAAATTACATTTTGGAT
TTGATATACGGCCTACACAAGCAAATCAACAGAGGGCTGAAGAAAATGGTACTGGGGTGG
GCCCCTGCACCCTTTAGTTGTGACTGGACCCCTAGTGACGAGAGGATCAGATTGCCAACA
GACAACTATTTGAGGGTAGAAACCAGGTGCCCATGTGGCTATGAGATGAAAGCTTTCAAA
AATGTAGGTGGCAAACTTACCAAAGTGGAGGAGAGCGGGCCTTTCCTATGTAGAAACAGA
CCTGGTAGGGGACCAGTCAACTACAGAGTCACCAAGTATTACGATGACAACCTCAGAGAG
ATAAAACCAGTAGCAAAGTTGGAAGGACAGGTAGAGCACTACTACAAAGGGGTCACAGCA
AAAATTGACTACAGTAAAGGAAAAATGCTCTTGGCCACTGACAAGTGGGAGGTGGAACAT
GGTGTCATAACCAGGTTAGCTAAGAGATATACTGGGGTCGGGTTCAATGGTGCATACTTA
GGTGACGAGCCCAATCACCGTGCTCTAGTGGAGAGGGACTGTGCAACTATAACCAAAAAC
ACAGTACAGTTTCTAAAAATGAAGAAGGGGTGTGCGTTCACCTATGACCTGACCATCTCC
AATCTGACCAGGCTCATCGAACTAGTACACAGGAACAATCTTGAAGAGAAGGAAATACCC
ACCGCTACGGTCACCACATGGCTAGCTTACACCTTCGTGAATGAAGACGTAGGGACTATA
AAACCAGTACTAGGAGAGAGAGTAATCCCCGACCCTGTAGTTGATATCAATTTACAACCA
GAGGTGCAAGTGGACACGTCAGAGGTTGGGATCACAATAATTGGAAGGGAAACCCTGATG
ACAACGGGAGTGACACCTGTCTTGGAAAAAGTAGAGCCTGACGCCAGCGACAACCAAAAC
TCGGTGAAGATCGGGTTGGATGAGGGTAATTACCCAGGGCCTGGAATACAGACACATACA
CTAACAGAAGAAATACACAACAGGGATGCGAGGCCCTTCATCATGATCCTGGGCTCAAGG
AATTCCATATCAAATAGGGCAAAGACTGCTAGAAATATAAATCTGTACACAGGAAATGAC
CCCAGGGAAATACGAGACTTGATGGCTGCAGGGCGCATGTTAGTAGTAGCACTGAGGGAT
GTCGACCCTGAGCTGTCTGAAATGGTCGATTTCAAGGGGACTTTTTTAGATAGGGAGGCC
CTGGAGGCTCTAAGTCTCGGGCAACCTAAACCGAAGCAGGTTACCAAGGAAGCTGTTAGG
AATTTGATAGAACAGAAAAAAGATGTGGAGATCCCTAACTGGTTTGCATCAGATGACCCA
GTATTTCTGGAAGTGGCCTTAAAAAATGATAAGTACTACTTAGTAGGAGATGTTGGAGAG
CTAAAAGATCAAGCTAAAGCACTTGGGGCCACGGATCAGACAAGAATTATAAAGGAGGTA
GGCTCAAGGACGTATGCCATGAAGCTATCTAGCTGGTTCCTCAAGGCATCAAACAAACAG
ATGAGTTTAACTCCACTGTTTGAGGAATTGTTGCTACGGTGCCCACCTGCAACTAAGAGC
AATAAGGGGCACATGGCATCAGCTTACCAATTGGCACAGGGTAACTGGGAGCCCCTCGGT
TGCGGGGTGCACCTAGGTACAATACCAGCCAGAAGGGTGAAGATACACCCATATGAAGCT
TACCTGAAGTTGAAAGATTTCATAGAAGAAGAAGAGAAGAAACCTAGGGTTAAGGATACA
GTAATAAGAGAGCACAACAAATGGATACTTAAAAAAATAAGGTTTCAAGGAAACCTCAAC
ACCAAGAAAATGCTCAACCCAGGGAAACTATCTGAACAGTTGGACAGGGAGGGGCGCAAG
AGGAACATCTACAACCACCAGATTGGTACTATAATGTCAAGTGCAGGCATAAGGCTGGAG
AAATTGCCAATAGTGAGGGCCCAAACCGACACCAAAACCTTTCATGAGGCAATAAGAGAT
AAGATAGACAAGAGTGAAAACCGGCAAAATCCAGAATTGCACAACAAATTGTTGGAGATT
TTCCACACGATAGCCCAACCCACCCTGAAACACACCTACGGTGAGGTGACGTGGGAGCAA
CTTGAGGCGGGGGTAAATAGAAAGGGGGCAGCAGGCTTCCTGGAGAAGAAGAACATCGGA
GAAGTATTGGATTCAGAAAAGCACCTGGTAGAACAATTGGTCAGGGATCTGAAGGCCGGG
AGAAAGATAAAATATTATGAAACTGCAATACCAAAAAATGAGAAGAGAGATGTCAGTGAT
GACTGGCAGGCAGGGGACCTGGTGGTTGAGAAGAGGCCAAGAGTTATCCAATACCCTGAA
GCCAAGACAAGGCTAGCCATCACTAAGGTCATGTATAACTGGGTGAAACAGCAGCCCGTT
GTGATTCCAGGATATGAAGGAAAGACCCCCTTGTTCAACATCTTTGATAAAGTGAGAAAG
GAATGGGACTCGTTCAATGAGCCAGTGGCCGTAAGTTTTGACACCAAAGCCTGGGACACT
CAAGTGACTAGTAAGGATCTGCAACTTATTGGAGAAATCCAGAAATATTACTATAAGAAG
GAGTGGCACAAGTTCATTGACACCATCACCGACCACATGACAGAAGTACCAGTTATAACA
GCAGATGGTGAAGTATATATAAGAAATGGGCAGAGAGGGAGCGGCCAGCCAGACACAAGT
GCTGGCAACAGCATGTTAAATGTCCTGACAATGATGTACGGCTTCTGCGAAAGCACAGGG
GTACCGTACAAGAGTTTCAACAGGGTGGCAAGGATCCACGTCTGTGGGGATGATGGCTTC
TTAATAACTGAAAAAGGGTTAGGGCTGAAATTTGCTAACAAAGGGATGCAGATTCTTCAT
GAAGCAGGCAAACCTCAGAAGATAACGGAAGGGGAAAAGATGAAAGTTGCCTATAGATTT
GAGGATATAGAGTTCTGTTCTCATACCCCAGTCCCTGTTAGGTGGTCCGACAACACCAGT
AGTCACATGGCCGGGAGAGACACCGCTGTGATACTATCAAAGATGGCAACAAGATTGGAT
TCAAGTGGAGAGAGGGGTACCACAGCATATGAAAAAGCGGTAGCCTTCAGTTTCTTGCTG
ATGTATTCCTGGAACCCGCTTGTTAGGAGGATTTGCCTGTTGGTCCTTTCGCAACAGCCA
GAGACAGACCCATCAAAACATGCCACTTATTATTACAAAGGTGATCCAATAGGGGCCTAT
AAAGATGTAATAGGTCGGAATCTAAGTGAACTGAAGAGAACAGGCTTTGAGAAATTGGCA
AATCTAAACCTAAGCCTGTCCACGTTGGGGGTCTGGACTAAGCACACAAGCAAAAGAATA
ATTCAGGACTGTGTTGCCATTGGGAAAGAAGAGGGCAACTGGCTAGTTAAGCCCGACAGG
CTGATATCCAGCAAAACTGGCCACTTATACATACCTGATAAAGGCTTTACATTACAAGGA
AAGCATTATGAGCAACTGCAGCTAAGAACAGAGACAAACCCGGTCATGGGGGTTGGGACT
GAGAGATACAAGTTAGGTCCCATAGTCAATCTGCTGCTGAGAAGGTTGAAAATTCTGCTC
ATGACGGCCGTCGGCGTCAGCAGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP19711
UniProtKB Entry NamePOLG_BVDVN
GenBank Protein ID323206
GenBank Gene IDM31182
General References
  1. Colett MS, Larson R, Gold C, Strick D, Anderson DK, Purchio AF: Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus. Virology. 1988 Jul;165(1):191-9. [Article]
  2. Collett MS, Larson R, Belzer SK, Retzel E: Proteins encoded by bovine viral diarrhea virus: the genomic organization of a pestivirus. Virology. 1988 Jul;165(1):200-8. [Article]
  3. Xu J, Mendez E, Caron PR, Lin C, Murcko MA, Collett MS, Rice CM: Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. J Virol. 1997 Jul;71(7):5312-22. [Article]
  4. Weiland F, Weiland E, Unger G, Saalmuller A, Thiel HJ: Localization of pestiviral envelope proteins E(rns) and E2 at the cell surface and on isolated particles. J Gen Virol. 1999 May;80 ( Pt 5):1157-65. [Article]
  5. Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX: Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12766-71. [Article]
  6. Iqbal M, Flick-Smith H, McCauley JW: Interactions of bovine viral diarrhoea virus glycoprotein E(rns) with cell surface glycosaminoglycans. J Gen Virol. 2000 Feb;81(Pt 2):451-9. [Article]
  7. Agapov EV, Murray CL, Frolov I, Qu L, Myers TM, Rice CM: Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus. J Virol. 2004 Mar;78(5):2414-25. [Article]
  8. Maurer K, Krey T, Moennig V, Thiel HJ, Rumenapf T: CD46 is a cellular receptor for bovine viral diarrhea virus. J Virol. 2004 Feb;78(4):1792-9. [Article]
  9. Lecot S, Belouzard S, Dubuisson J, Rouille Y: Bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis. J Virol. 2005 Aug;79(16):10826-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04137Guanosine-5'-TriphosphateexperimentalunknownDetails