T-cell surface glycoprotein CD3 zeta chain

Details

Name
T-cell surface glycoprotein CD3 zeta chain
Synonyms
  • CD3Z
  • T-cell receptor T3 zeta chain
  • T3Z
  • TCRZ
Gene Name
CD247
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006729|T-cell surface glycoprotein CD3 zeta chain
MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSAD
APAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMA
EAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR
Number of residues
164
Molecular Weight
18696.275
Theoretical pI
9.65
GO Classification
Functions
identical protein binding / protein homodimerization activity / transmembrane signaling receptor activity
Processes
Fc-gamma receptor signaling pathway involved in phagocytosis / innate immune response / regulation of defense response to virus by virus / regulation of immune response / T cell costimulation / T cell receptor signaling pathway / viral process
Components
alpha-beta T cell receptor complex / cytoplasm / integral component of membrane / plasma membrane / T cell receptor complex
General Function
Transmembrane signaling receptor activity
Specific Function
Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Pfam Domain Function
Transmembrane Regions
31-51
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0017108|T-cell surface glycoprotein CD3 zeta chain (CD247)
ATGAAGTGGAAGGCGCTTTTCACCGCGGCCATCCTGCAGGCACAGTTGCCGATTACAGAG
GCACAGAGCTTTGGCCTGCTGGATCCCAAACTCTGCTACCTGCTGGATGGAATCCTCTTC
ATCTATGGTGTCATTCTCACTGCCTTGTTCCTGAGAGTGAAGTTCAGCAGGAGCGCAGAC
GCCCCCGCGTACCAGCAGGGCCAGAACCAGCTCTATAACGAGCTCAATCTAGGACGAAGA
GAGGAGTACGATGTTTTGGACAAGAGACGTGGCCGGGACCCTGAGATGGGGGGAAAGCCG
AGAAGGAAGAACCCTCAGGAAGGCCTGTACAATGAACTGCAGAAAGATAAGATGGCGGAG
GCCTACAGTGAGATTGGGATGAAAGGCGAGCGCCGGAGGGGCAAGGGGCACGATGGCCTT
TACCAGGGTCTCAGTACAGCCACCAAGGACACCTACGACGCCCTTCACATGCAGGCCCTG
CCCCCTCGCTAA
Chromosome Location
1
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP20963
UniProtKB Entry NameCD3Z_HUMAN
GenBank Gene IDBC025703
GenAtlas IDCD247
HGNC IDHGNC:1677
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00075Muromonabapproved, investigationalyesDetails
DB16655Teclistamabapproved, investigationalyesantibodyDetails
DB16684OdronextamabinvestigationalyesbinderDetails
DB16371Glofitamabapproved, investigationalyesbinderantibodyDetails
DB15395Elranatamabapproved, investigationalunknownantibodyDetails
DB16678Talquetamabapproved, investigationalyesantibodyDetails