Matrix protein 2

Details

Name
Matrix protein 2
Synonyms
  • Proton channel protein M2
Gene Name
M
Organism
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
Amino acid sequence
>lcl|BSEQ0001256|Matrix protein 2
MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDHLFFKCIYRFFKHGLK
RGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE
Number of residues
97
Molecular Weight
11165.62
Theoretical pI
4.87
GO Classification
Functions
hydrogen ion transmembrane transporter activity / ion channel activity
Processes
pore formation by virus in membrane of host cell / protein oligomerization / suppression by virus of host autophagy
Components
host cell plasma membrane / integral component of membrane / integral to membrane of host cell / virion membrane
General Function
Ion channel activity
Specific Function
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).
Pfam Domain Function
Transmembrane Regions
23-43
Cellular Location
Virion membrane
Gene sequence
>lcl|BSEQ0001255|294 bp
ATGAGTCTTCTAACCGAGGTCGAAACGCCTATCAGAAACGAATGGGGGTGCAGATGCAAC
GATTCAAGTGACCCTCTTGTTGTTGCCGCGAGTATCATTGGGATCTTGCACTTGATATTG
TGGATTCTTGATCATCTTTTTTTCAAATGCATTTATCGCTTCTTTAAACACGGTCTGAAA
AGAGGGCCTTCTACGGAAGGAGTACCAGAGTCTATGAGGGAAGAATATCGAAAGGAACAG
CAGAGTGCTGTGGATGCTGACGATAGTCATTTTGTCAGCATAGAGCTGGAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP21430
UniProtKB Entry NameM2_I60A0
GenBank Protein ID324265
GenBank Gene IDM23978
General References
  1. Cox NJ, Kitame F, Kendal AP, Maassab HF, Naeve C: Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2). Virology. 1988 Dec;167(2):554-67. [Article]
  2. Nayak DP, Hui EK, Barman S: Assembly and budding of influenza virus. Virus Res. 2004 Dec;106(2):147-65. [Article]
  3. Lear JD: Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data. FEBS Lett. 2003 Sep 18;552(1):17-22. [Article]
  4. Wu Y, Voth GA: Computational studies of proton transport through the M2 channel. FEBS Lett. 2003 Sep 18;552(1):23-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00478Rimantadineapproved, investigationalyesother/unknownDetails
DB00915AmantadineapprovedyesinhibitorDetails