Granulysin

Details

Name
Granulysin
Synonyms
  • LAG2
  • Lymphokine LAG-2
  • NKG5
  • Protein NKG5
  • T-cell activation protein 519
  • TLA519
Gene Name
GNLY
Organism
Humans
Amino acid sequence
>lcl|BSEQ0003815|Granulysin
MATWALLLLAAMLLGNPGLVFSRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQ
ELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQ
GLVAGETAQQICEDLRLCIPSTGPL
Number of residues
145
Molecular Weight
16373.83
Theoretical pI
9.4
GO Classification
Processes
cellular defense response / defense response to bacterium / defense response to fungus / killing of cells of other organism
Components
extracellular space
General Function
Not Available
Specific Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0016616|Granulysin (GNLY)
ATGGCTACCTGGGCCCTCCTGCTCCTTGCAGCCATGCTCCTGGGCAACCCAGGCCTTGAG
GTCAGTGTGAGCCCCAAGGGCAAGAACACTTCTGGAAGGGAGAGTGGATTTGGCTGGGCC
ATCTGGATGGAAGGTCTGGTCTTCTCTCGTCTGAGCCCTGAGTACTACGACCTGGCAAGA
GCCCACCTGCGTGATGAGGAGAAATCCTGCCCGTGCCTGGCCCAGGAGGGCCCCCAGGGT
GACCTGTTGACCAAAACACAGGAGCTGGGCCGTGACTACAGGACCTGTCTGACGATAGTC
CAAAAACTGAAGAAGATGGTGGATAAGCCCACCCAGAGAAGTGTTTCCAATGCTGCGACC
CGGGTGTGTAGGACGGGGAGGTCACGATGGCGCGACGTCTGCAGAAATTTCATGAGGAGG
TATCAGTCTAGAGTTACCCAGGGCCTCGTGGCCGGAGAAACTGCCCAGCAGATCTGTGAG
GACCTCAGGTTGTGTATACCTTCTACAGGTCCCCTCTGA
Chromosome Location
2
Locus
2p12-q11
External Identifiers
ResourceLink
UniProtKB IDP22749
UniProtKB Entry NameGNLY_HUMAN
GenBank Protein ID36668
GenBank Gene IDX05044
GenAtlas IDGNLY
HGNC IDHGNC:4414
General References
  1. Jongstra J, Schall TJ, Dyer BJ, Clayberger C, Jorgensen J, Davis MM, Krensky AM: The isolation and sequence of a novel gene from a human functional T cell line. J Exp Med. 1987 Mar 1;165(3):601-14. [Article]
  2. Yabe T, McSherry C, Bach FH, Houchins JP: A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. J Exp Med. 1990 Oct 1;172(4):1159-63. [Article]
  3. Houchins JP, Kricek F, Chujor CS, Heise CP, Yabe T, McSherry C, Bach FH: Genomic structure of NKG5, a human NK and T cell-specific activation gene. Immunogenetics. 1993;37(2):102-7. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Krensky AM: Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. Biochem Pharmacol. 2000 Feb 15;59(4):317-20. [Article]
  6. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL: An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 2;282(5386):121-5. [Article]
  7. Hanson DA, Kaspar AA, Poulain FR, Krensky AM: Biosynthesis of granulysin, a novel cytolytic molecule. Mol Immunol. 1999 May;36(7):413-22. [Article]
  8. Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D: Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol. 2003 Jan 10;325(2):355-65. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB034343-(N-morpholino)propanesulfonic acidexperimentalunknownDetails