Granulysin
Details
- Name
- Granulysin
- Synonyms
- LAG2
- Lymphokine LAG-2
- NKG5
- Protein NKG5
- T-cell activation protein 519
- TLA519
- Gene Name
- GNLY
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0003815|Granulysin MATWALLLLAAMLLGNPGLVFSRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQ ELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQ GLVAGETAQQICEDLRLCIPSTGPL
- Number of residues
- 145
- Molecular Weight
- 16373.83
- Theoretical pI
- 9.4
- GO Classification
- Processescellular defense response / defense response to bacterium / defense response to fungus / killing of cells of other organismComponentsextracellular space
- General Function
- Not Available
- Specific Function
- Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
- Pfam Domain Function
- SapB_2 (PF03489)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016616|Granulysin (GNLY) ATGGCTACCTGGGCCCTCCTGCTCCTTGCAGCCATGCTCCTGGGCAACCCAGGCCTTGAG GTCAGTGTGAGCCCCAAGGGCAAGAACACTTCTGGAAGGGAGAGTGGATTTGGCTGGGCC ATCTGGATGGAAGGTCTGGTCTTCTCTCGTCTGAGCCCTGAGTACTACGACCTGGCAAGA GCCCACCTGCGTGATGAGGAGAAATCCTGCCCGTGCCTGGCCCAGGAGGGCCCCCAGGGT GACCTGTTGACCAAAACACAGGAGCTGGGCCGTGACTACAGGACCTGTCTGACGATAGTC CAAAAACTGAAGAAGATGGTGGATAAGCCCACCCAGAGAAGTGTTTCCAATGCTGCGACC CGGGTGTGTAGGACGGGGAGGTCACGATGGCGCGACGTCTGCAGAAATTTCATGAGGAGG TATCAGTCTAGAGTTACCCAGGGCCTCGTGGCCGGAGAAACTGCCCAGCAGATCTGTGAG GACCTCAGGTTGTGTATACCTTCTACAGGTCCCCTCTGA
- Chromosome Location
- 2
- Locus
- 2p12-q11
- External Identifiers
Resource Link UniProtKB ID P22749 UniProtKB Entry Name GNLY_HUMAN GenBank Protein ID 36668 GenBank Gene ID X05044 GenAtlas ID GNLY HGNC ID HGNC:4414 - General References
- Jongstra J, Schall TJ, Dyer BJ, Clayberger C, Jorgensen J, Davis MM, Krensky AM: The isolation and sequence of a novel gene from a human functional T cell line. J Exp Med. 1987 Mar 1;165(3):601-14. [Article]
- Yabe T, McSherry C, Bach FH, Houchins JP: A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein. J Exp Med. 1990 Oct 1;172(4):1159-63. [Article]
- Houchins JP, Kricek F, Chujor CS, Heise CP, Yabe T, McSherry C, Bach FH: Genomic structure of NKG5, a human NK and T cell-specific activation gene. Immunogenetics. 1993;37(2):102-7. [Article]
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- Krensky AM: Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. Biochem Pharmacol. 2000 Feb 15;59(4):317-20. [Article]
- Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL: An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 1998 Oct 2;282(5386):121-5. [Article]
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