Platelet-activating factor receptor
Details
- Name
- Platelet-activating factor receptor
- Synonyms
- PAF-R
- PAFR
- Gene Name
- PTAFR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019761|Platelet-activating factor receptor MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
- Number of residues
- 342
- Molecular Weight
- 39203.075
- Theoretical pI
- Not Available
- GO Classification
- FunctionsG-protein coupled purinergic nucleotide receptor activity / G-protein coupled receptor activity / lipopolysaccharide binding / lipopolysaccharide receptor activity / phospholipid binding / platelet activating factor receptor activityProcesseschemotaxis / cytokine production / cytokine-mediated signaling pathway / G-protein coupled purinergic nucleotide receptor signaling pathway / G-protein coupled receptor signaling pathway / immune response / inflammatory response / inositol trisphosphate biosynthetic process / interferon-gamma-mediated signaling pathway / phosphatidylinositol-mediated signalingComponentsintegral component of membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / membrane / nucleoplasm / plasma membrane
- General Function
- Platelet activating factor receptor activity
- Specific Function
- Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 17-38 55-74 92-113 134-155 185-205 234-254 277-296
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019762|Platelet-activating factor receptor (PTAFR) ATGGAGCCACATGACTCCTCCCACATGGACTCTGAGTTCCGATACACTCTCTTCCCGATT GTTTACAGCATCATCTTTGTGCTCGGGGTCATTGCTAATGGCTACGTGCTGTGGGTCTTT GCCCGCCTGTACCCTTGCAAGAAATTCAATGAGATAAAGATCTTCATGGTGAACCTCACC ATGGCGGACATGCTCTTCTTGATCACCCTGCCACTTTGGATTGTCTACTACCAAAACCAG GGCAACTGGATACTCCCCAAATTCCTGTGCAACGTGGCTGGCTGCCTTTTCTTCATCAAC ACCTACTGCTCTGTGGCCTTCCTGGGCGTCATCACTTATAACCGCTTCCAGGCAGTAACT CGGCCCATCAAGACTGCTCAGGCCAACACCCGCAAGCGTGGCATCTCTTTGTCCTTGGTC ATCTGGGTGGCCATTGTGGGAGCTGCATCCTACTTCCTCATCCTGGACTCCACCAACACA GTGCCCGACAGTGCTGGCTCAGGCAACGTCACTCGCTGCTTTGAGCATTACGAGAAGGGC AGCGTGCCAGTCCTCATCATCCACATCTTCATCGTGTTCAGCTTCTTCCTGGTCTTCCTC ATCATCCTCTTCTGCAACCTGGTCATCATCCGTACCTTGCTCATGCAGCCGGTGCAGCAG CAGCGCAACGCTGAAGTCAAGCGCCGGGCGCTGTGGATGGTGTGCACGGTCTTGGCGGTG TTCATCATCTGCTTCGTGCCCCACCACGTGGTGCAGCTGCCCTGGACCCTTGCTGAGCTG GGCTTCCAGGACAGCAAATTCCACCAGGCCATTAATGATGCACATCAGGTCACCCTCTGC CTCCTTAGCACCAACTGTGTCTTAGACCCTGTTATCTACTGTTTCCTCACCAAGAAGTTC CGCAAGCACCTCACCGAAAAGTTCTACAGCATGCGCAGTAGCCGGAAATGCTCCCGGGCC ACCACGGATACGGTCACTGAAGTGGTTGTGCCATTCAACCAGATCCCTGGCAATTCCCTC AAAAATTAG
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25105 UniProtKB Entry Name PTAFR_HUMAN HGNC ID HGNC:9582 - General References
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- Nakamura M, Honda Z, Izumi T, Sakanaka C, Mutoh H, Minami M, Bito H, Seyama Y, Matsumoto T, Noma M, et al.: Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J Biol Chem. 1991 Oct 25;266(30):20400-5. [Article]
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