Interleukin-3 receptor subunit alpha

Details

Synonyms

IL-3 receptor subunit alpha
IL3R

Gene Name

IL3RA

Organism

Humans

Amino acid sequence

>lcl|BSEQ0002063|Interleukin-3 receptor subunit alpha
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM
PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL
SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS
HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL
QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN
TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG
KAGLEECLVTEVQVVQKT

Number of residues

378

Molecular Weight

43329.585

Theoretical pI

8.32

GO Classification

Functions

interleukin-3 receptor activity

Processes

activation of MAPKK activity / axon guidance / cellular response to interleukin-3 / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / innate immune response / insulin receptor signaling pathway / interleukin-3-mediated signaling pathway / MAPK cascade / neurotrophin TRK receptor signaling pathway / Ras protein signal transduction / small GTPase mediated signal transduction / vascular endothelial growth factor receptor signaling pathway

Components

integral component of membrane / intracellular / plasma membrane

General Function

Interleukin-3 receptor activity

Specific Function

This is a receptor for interleukin-3.

Pfam Domain Function

IL6Ra-bind (PF09240)

Transmembrane Regions

306-325

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0020503|Interleukin-3 receptor subunit alpha (IL3RA)
ATGGTCCTCCTTTGGCTCACGCTGCTCCTGATCGCCCTGCCCTGTCTCCTGCAAACGAAG
GAAGGTGGGAAGCCTTGGGCAGGTGCGGAGAATCTGACCTGCTGGATTCATGACGTGGAT
TTCTTGAGCTGCAGCTGGGCGGTAGGCCCGGGGGCCCCCGCGGACGTCCAGTACGACCTG
TACTTGAACGTTGCCAACAGGCGTCAACAGTACGAGTGTCTTCACTACAAAACGGATGCT
CAGGGAACACGTATCGGGTGTCGTTTCGATGACATCTCTCGACTCTCCAGCGGTTCTCAA
AGTTCCCACATCCTGGTGCGGGGCAGGAGCGCAGCCTTCGGTATCCCCTGCACAGATAAG
TTTGTCGTCTTTTCACAGATTGAGATATTAACTCCACCCAACATGACTGCAAAGTGTAAT
AAGACACATTCCTTTATGCACTGGAAAATGAGAAGTCATTTCAATCGCAAATTTCGCTAT
GAGCTTCAGATACAAAAGAGAATGCAGCCTGTAATCACAGAACAGGTCAGAGACAGAACC
TCCTTCCAGCTACTCAATCCTGGAACGTACACAGTACAAATAAGAGCCCGGGAAAGAGTG
TATGAATTCTTGAGCGCCTGGAGCACCCCCCAGCGCTTCGAGTGCGACCAGGAGGAGGGC
GCAAACACACGTGCCTGGCGGACGTCGCTGCTGATCGCGCTGGGGACGCTGCTGGCCCTG
GTCTGTGTCTTCGTGATCTGCAGAAGGTATCTGGTGATGCAGAGACTCTTTCCCCGCATC
CCTCACATGAAAGACCCCATCGGTGACAGCTTCCAAAACGACAAGCTGGTGGTCTGGGAG
GCGGGCAAAGCCGGCCTGGAGGAGTGTCTGGTGACTGAAGTACAGGTCGTGCAGAAAACT
TGA

Chromosome Location

X, Y

Locus

Xp22.3 or Yp11.3

External Identifiers

Resource	Link
UniProtKB ID	P26951
UniProtKB Entry Name	IL3RA_HUMAN
GenBank Protein ID	186331
GenBank Gene ID	M74782
GenAtlas ID	IL3RA
HGNC ID	HGNC:6012

General References

Kitamura T, Sato N, Arai K, Miyajima A: Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell. 1991 Sep 20;66(6):1165-74. [Article]
Kosugi H, Nakagawa Y, Hotta T, Saito H, Miyajima A, Arai K, Yokota T: Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor. Biochem Biophys Res Commun. 1995 Mar 8;208(1):360-7. [Article]
Chen J, Olsen J, Ford S, Mirza S, Walker A, Murphy JM, Young IG: A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. J Biol Chem. 2009 Feb 27;284(9):5763-73. doi: 10.1074/jbc.M808197200. Epub 2008 Dec 24. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00020	Sargramostim	approved, investigational	yes	agonist	Details
DB14731	Tagraxofusp	approved, investigational	yes	ligand	Details