60S ribosomal protein L10

Details

Name
60S ribosomal protein L10
Synonyms
  • DXS648E
  • Laminin receptor homolog
  • Large ribosomal subunit protein uL16
  • Protein QM
  • QM
  • Tumor suppressor QM
Gene Name
RPL10
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049916|60S ribosomal protein L10
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQL
SSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
Number of residues
214
Molecular Weight
24603.705
Theoretical pI
Not Available
GO Classification
Functions
RNA binding / structural constituent of ribosome
Processes
negative regulation of apoptotic process / negative regulation of transcription from RNA polymerase II promoter / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / ribosomal large subunit assembly / rRNA processing / SRP-dependent cotranslational protein targeting to membrane / translation / translational initiation / viral transcription
Components
cytosol / cytosolic large ribosomal subunit / endoplasmic reticulum / membrane / nucleus / protein complex
General Function
Component of the large ribosomal subunit.
Specific Function
Rna binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0049917|60S ribosomal protein L10 (RPL10)
ATGGGCCGCCGCCCCGCCCGTTGTTACCGGTATTGTAAGAACAAGCCGTACCCAAAGTCT
CGCTTCTGCCGAGGTGTCCCTGATGCCAAGATTCGCATTTTTGACCTGGGGCGGAAAAAG
GCAAAAGTGGATGAGTTTCCGCTTTGTGGCCACATGGTGTCAGATGAATATGAGCAGCTG
TCCTCTGAAGCCCTGGAGGCTGCCCGAATTTGTGCCAATAAGTACATGGTAAAAAGTTGT
GGCAAAGATGGCTTCCATATCCGGGTGCGGCTCCACCCCTTCCACGTCATCCGCATCAAC
AAGATGTTGTCCTGTGCTGGGGCTGACAGGCTCCAAACAGGCATGCGAGGTGCCTTTGGA
AAGCCCCAGGGCACTGTGGCCAGGGTTCACATTGGCCAAGTTATCATGTCCATCCGCACC
AAGCTGCAGAACAAGGAGCATGTGATTGAGGCCCTGCGCAGGGCCAAGTTCAAGTTTCCT
GGCCGCCAGAAGATCCACATCTCAAAGAAGTGGGGCTTCACCAAGTTCAATGCTGATGAA
TTTGAAGACATGGTGGCTGAAAAGCGGCTCATCCCAGATGGCTGTGGGGTCAAGTACATC
CCCAGTCGTGGCCCTCTGGACAAGTGGCGGGCCCTGCACTCATGA
Chromosome Location
X
Locus
Xq28
External Identifiers
ResourceLink
UniProtKB IDP27635
UniProtKB Entry NameRL10_HUMAN
HGNC IDHGNC:10298
General References
  1. Dowdy SF, Lai KM, Weissman BE, Matsui Y, Hogan BL, Stanbridge EJ: The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. Nucleic Acids Res. 1991 Oct 25;19(20):5763-9. [Article]
  2. van den Ouweland AM, Kioschis P, Verdijk M, Tamanini F, Toniolo D, Poustka A, van Oost BA: Identification and characterization of a new gene in the human Xq28 region. Hum Mol Genet. 1992 Jul;1(4):269-73. [Article]
  3. Kaneko K, Kobayashi H, Onodera O, Miyatake T, Tsuji S: Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28. Hum Mol Genet. 1992 Oct;1(7):529-33. [Article]
  4. Oh HS, Kwon H, Sun SK, Yang CH: QM, a putative tumor suppressor, regulates proto-oncogene c-yes. J Biol Chem. 2002 Sep 27;277(39):36489-98. Epub 2002 Jul 22. [Article]
  5. Shen XJ, Ali-Fehmi R, Weng CR, Sarkar FH, Grignon D, Liao DJ: Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer. Cancer Biol Ther. 2006 May;5(5):523-8. Epub 2006 May 15. [Article]
  6. Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. Hum Mol Genet. 1996 May;5(5):659-68. [Article]
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  14. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
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  16. Nishimura M, Kaminishi T, Takemoto C, Kawazoe M, Yoshida T, Tanaka A, Sugano S, Shirouzu M, Ohkubo T, Yokoyama S, Kobayashi Y: Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. J Mol Biol. 2008 Mar 21;377(2):421-30. doi: 10.1016/j.jmb.2008.01.003. Epub 2008 Jan 11. [Article]
  17. Klauck SM, Felder B, Kolb-Kokocinski A, Schuster C, Chiocchetti A, Schupp I, Wellenreuther R, Schmotzer G, Poustka F, Breitenbach-Koller L, Poustka A: Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Mol Psychiatry. 2006 Dec;11(12):1073-84. Epub 2006 Aug 29. [Article]
  18. Chiocchetti A, Pakalapati G, Duketis E, Wiemann S, Poustka A, Poustka F, Klauck SM: Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder. Am J Med Genet A. 2011 Jun;155A(6):1472-5. doi: 10.1002/ajmg.a.33977. Epub 2011 May 12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails