Neuraminidase

Details

Name
Neuraminidase
Synonyms
  • 3.2.1.18
Gene Name
NA
Organism
Influenza B virus (strain B/Beijing/1/1987)
Amino acid sequence
>lcl|BSEQ0012456|Neuraminidase
MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSSKITAPTMTLDCANASNVQ
AVNRSATKEMTFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIA
CGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSA
CHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMIT
DGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRP
FVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKI
GRWYSRTMSKTERMGMELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCD
VPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
Number of residues
465
Molecular Weight
51429.21
Theoretical pI
7.55
GO Classification
Functions
exo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activity / metal ion binding
Processes
carbohydrate metabolic process
Components
host cell plasma membrane / integral component of membrane / virion membrane
General Function
Metal ion binding
Specific Function
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells (By similarity).
Pfam Domain Function
Transmembrane Regions
7-35
Cellular Location
Virion membrane
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP27907
UniProtKB Entry NameNRAM_INBBE
GenBank Gene IDM54967
General References
  1. Burmeister WP, Daniels RS, Dayan S, Gagnon J, Cusack S, Ruigrok RW: Sequence and crystallization of influenza virus B/Beijing/1/87 neuraminidase. Virology. 1991 Jan;180(1):266-72. [Article]
  2. Moscona A: Neuraminidase inhibitors for influenza. N Engl J Med. 2005 Sep 29;353(13):1363-73. [Article]
  3. Burmeister WP, Ruigrok RW, Cusack S: The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid. EMBO J. 1992 Jan;11(1):49-56. [Article]
  4. Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J: Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. J Med Chem. 1998 Mar 12;41(6):798-807. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00558Zanamivirapproved, investigationalyesinhibitorDetails
DB06614Peramivirapproved, investigationalunknownDetails