Lantibiotic nisin-Z

Details

Name
Lantibiotic nisin-Z
Synonyms
Not Available
Gene Name
nisZ
Organism
Lactococcus lactis subsp. lactis
Amino acid sequence
>lcl|BSEQ0017325|Lantibiotic nisin-Z
MSTKDFNLDLVSVSKKDSGASPRITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK
Number of residues
57
Molecular Weight
5939.87
Theoretical pI
8.8
GO Classification
Processes
cytolysis / defense response to bacterium
Components
extracellular region
General Function
Not Available
Specific Function
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0007808|174 bp
ATGAGTACAAAAGATTTTAACTTGGATTTGGTATCTGTTTCGAAGAAAGATTCAGGTGCA
TCACCACGCATTACAAGTATTTCGCTATGTACACCCGGTTGTAAAACAGGAGCTCTGATG
GGTTGTAACATGAAAACAGCAACTTGTAATTGTAGTATTCACGTAAGCAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP29559
UniProtKB Entry NameLANZ_LACLL
GenBank Protein ID44047
GenBank Gene IDX61144
General References
  1. Mulders JW, Boerrigter IJ, Rollema HS, Siezen RJ, de Vos WM: Identification and characterization of the lantibiotic nisin Z, a natural nisin variant. Eur J Biochem. 1991 Nov 1;201(3):581-4. [Article]
  2. Immonen T, Ye S, Ra R, Qiao M, Paulin L, Saris PE: The codon usage of the nisZ operon in Lactococcus lactis N8 suggests a non-lactococcal origin of the conjugative nisin-sucrose transposon. DNA Seq. 1995;5(4):203-18. [Article]
  3. Hsu ST, Breukink E, Tischenko E, Lutters MA, de Kruijff B, Kaptein R, Bonvin AM, van Nuland NA: The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics. Nat Struct Mol Biol. 2004 Oct;11(10):963-7. Epub 2004 Sep 12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07780Farnesyl diphosphateexperimentalunknownDetails