Epidermin decarboxylase
Details
- Name
- Epidermin decarboxylase
- Synonyms
- 4.1.1.-
- Epidermin-modifying enzyme EpiD
- Gene Name
- epiD
- Organism
- Staphylococcus epidermidis
- Amino acid sequence
>lcl|BSEQ0012112|Epidermin decarboxylase MYGKLLICATASINVININHYIVELKQHFDEVNILFSPSSKNFINTDVLKLFCDNLYDEI KDPLLNHINIVENHEYILVLPASANTINKIANGICDNLLTTVCLTGYQKLFIFPNMNIRM WGNPFLQKNIDLLKNNDVKVYSPDMNKSFEISSGRYKNNITMPNIENVLNFVLNNEKRPL D
- Number of residues
- 181
- Molecular Weight
- 20824.89
- Theoretical pI
- 6.5
- GO Classification
- Functionslyase activity
- General Function
- Lyase activity
- Specific Function
- Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.
- Pfam Domain Function
- Flavoprotein (PF02441)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0005897|546 bp ATGTATGGAAAATTATTGATATGCGCTACAGCATCGATAAATGTAATTAATATTAATCAC TACATAGTTGAGTTAAAGCAACATTTTGATGAAGTTAATATATTATTTAGTCCTAGTAGT AAAAATTTTATAAATACTGATGTTCTCAAGTTATTTTGTGATAACTTGTACGATGAAATT AAAGATCCTCTTTTAAATCATATCAATATTGTAGAAAATCATGAATATATTTTAGTATTA CCTGCATCAGCAAATACTATTAATAAAATAGCTAATGGTATATGTGATAATCTTTTAACT ACTGTATGTTTAACCGGATATCAAAAATTATTTATATTTCCAAATATGAACATAAGAATG TGGGGAAATCCATTTTTACAAAAAAATATTGATTTACTTAAAAATAATGATGTGAAAGTG TATTCCCCTGATATGAATAAATCATTCGAAATATCTAGTGGCCGTTACAAAAACAATATC ACAATGCCTAATATTGAAAATGTACTAAATTTTGTATTAAATAACGAAAAAAGACCTTTG GATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P30197 UniProtKB Entry Name EPID_STAEP GenBank Gene ID X62386 - General References
- Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gotz F, Entian KD: Analysis of genes involved in the biosynthesis of lantibiotic epidermin. Eur J Biochem. 1992 Feb 15;204(1):57-68. [Article]
- Kupke T, Stevanovic S, Sahl HG, Gotz F: Purification and characterization of EpiD, a flavoprotein involved in the biosynthesis of the lantibiotic epidermin. J Bacteriol. 1992 Aug;174(16):5354-61. [Article]
- Kupke T, Uebele M, Schmid D, Jung G, Blaesse M, Steinbacher S: Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J Biol Chem. 2000 Oct 13;275(41):31838-46. [Article]
- Blaesse M, Kupke T, Huber R, Steinbacher S: Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate. EMBO J. 2000 Dec 1;19(23):6299-310. [Article]